Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up

Sancho, Ligia; Kramer, Michal; Koriat, Adi; Eiger-Moscovich, Maya; Sharon, Yael; Amer, Radgonde

doi:10.1080/09273948.2017.1420203

Cited by 29 publications

(24 citation statements)

References 13 publications

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“…The previous studies showed that uveitis, especially chronic uveitis, would lead to band keratopathy. 20,21 Nevertheless, the inflammatory process in uveitis that involves cytokine alteration such as IL-6 and TNF may influence the corneal condition, 17 because the use of cyclosporine that suppresses interleukin activity can relieve some categories of keratopathies. 22 Moreover, the corneal endothelial cells were damaged with an altered central corneal thickness in patients with uveitis, [14][15][16]23 whereas inflammatory cell infiltration into the corneal stoma was also observed during the onset of anterior uveitis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Nien

Lee

Chao

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. METHODS. Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four nonuveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. RESULTS. A total of 4773 uveitis patients (2662 male and 2111 female) and 19,092 non-uveitis patients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR ¼ 1.765) and panuveitis (aHR ¼ 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. CONCLUSIONS. The presence of uveitis significantly elevates the risk for developing keratopathy.

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Section: Discussionmentioning

confidence: 99%

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Nien

Lee

Chao

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…10 In another study of patients with intermediate uveitis, the most common complications were cystoid macular edema, cataracts, and posterior synechia, and glaucoma was also noted. 11 The pathogenesis of secondary VPRT associated with intermediate uveitis is believed to involve a reactive process against factors released into the environment with the emergence of uncontrolled proliferation of fibrous tissue and angiogenesis in the retina secondary to disruption of the blood-retina barrier. 2 On the other hand, it has also been suggested that the presence of intraocular inflammation and uveitis may be due to a reactive, or "spillover" phenomenon in which inflammatory cells leak from tumoral lesion vessels into the vitreous.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Vasoproliferative Tumor and Uveitis in a Multiple Sclerosis Patient: A Case Report and Review of the Literature

Özalp¹,

Atalay²,

Bilgeç³

et al. 2019

tjo

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Vasoproliferative retinal tumor (VPRT) is a rare, benign lesion with a variable clinical course depending on the individual. Favorable outcomes are obtained with early diagnosis and treatment of patients with VPRT. In this case report, we present a case of concomitant VPRT and multiple sclerosis along with our management of uveitis and secondary glaucoma that presumably developed following cryotherapy for VPRT.

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“…Intermediate uveitis with its centre of inflammation in the vitreous body and peripheral retina anterior to the equator usually occurs as pars planitis as a disease in its own right and much more rarely in the scope of sarcoidosis (including Blau syndrome) or juvenile multiple sclerosis [8]. Even though both aforementioned underlying diseases combined occur in less than 10 [10].…”

Section: Intermediate Uveitismentioning

confidence: 99%

“…It occurs mostly occurs on both sides and must not necessarily appear as granulomatous inflammation in all cases [13]. In terms of treatment, the focus is on systemic steroids in 64 % of children; steroid-sparing drugs (MTX, ciclosporin, TNF inhibitors and mycophenolate) are used in 42 % [8].…”

Section: Intermediate Uveitismentioning

confidence: 99%

Childhood Uveitis

Thurau

2020

Klin Monbl Augenheilkd

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Childhood uveitis is an ophthalmological challenge, since on the one hand it often remains asymptomatic and difficult to detect, and on the other hand it often has a chronic course and is associated with a high risk of complications threatening the vision. The most important risk factors for childhood uveitis are underlying rheumatic diseases; recommendations for ophthalmological monitoring have been developed together with paediatric rheumatologists. Intermediate and posterior uveitis are rare in children. The therapy must effectively control inflammation and at the same time cause only minimal side effects. Since steroids in particular cause side effects frequently, an immunosuppressive therapy must be initiated early in an interdisciplinary cooperation with paediatric rheumatologists and parents with the goal of minimising steroids.

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Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up

Cited by 29 publications

References 13 publications

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

The Relationship Between Vasoproliferative Tumor and Uveitis in a Multiple Sclerosis Patient: A Case Report and Review of the Literature

Childhood Uveitis

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