Complications in neonates of mothers with gestational diabetes mellitus receiving insulin therapy versus dietary regimen

Fazel-Sarjoui, Zhaleh; Namin, Amirali Khodayari; Maryam, Kamali; Namin, Nazanin Khodayari; Tajik, Ali

doi:10.29252/ijrm.14.4.275

Cited by 7 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Maternal and foetal health might be negatively impacted by the gestational diabetes mellitus (GDM), a common obstetrical issue. 2 Since the introduction of specialised maternal, foetal and neonatal care for those women who have diabetes and their offsprings, the morbidity and mortality rates for infants of diabetic mothers have decreased by roughly 30 times. Before that time, the combined foetal and neonatal rate of death had reached to 65%.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Hypocalcemia in Infants of Diabetic Mothers within 24 Hours of Life

Awan¹,

Abbas²,

Naz³

et al. 2023

PJMHS

View full text Add to dashboard Cite

Objective: To find frequency of Hypocalcemia in infants of diabetic mothers within 24 hours of life. Study Design: It was a cross-sectional study. Study Duration: The study was conducted at paediatric department of Ittifaq hospital Lahore from April 12, 2018 till Oct 12, 2019. Material and Methods: A total of 260 cases after getting approval of synopsis were taken from Neonatal ward after delivery from Ittifaq hospital Lahore. All neonates fulfilling / meeting inclusion criteria were assessed for hypocalcaemia. Their basic history like age (hours), gender, gestational age, birth weight and baseline calcium level were noted. Venous blood was taken for analysis of calcium level and hypocalcaemia was labeled as per operational definition. Results: The mean age of infants was 11.92 ± 6.66 hours with minimum and maximum age as 1 and 24 hours. There were 137(52.7%) male and 123(47.3%) female cases, with higher male to female ratio. The mean gestational age was 39.48 ± 1.68 weeks with minimum and maximum gestational age as 37 and 42 weeks. The mean birth weight was 3193.99 ± 404.12 g with minimum and maximum birth weight as 2500 and 3892 grams. A total of 67(25.8%) neonates had hypocalcaemia while 193(74.2%) neonates had normal calcium level. Practical implication: This study was done to determine the frequency of neonatal hypocalcemia among infants with maternal hypocalcemia due to the lack of data, especially at the local level. If diagnosed early, they can begin treatment right away, which could reduce their mortality and morbidity in our region of the world. Conclusion: Through the findings of this study, it is concluded that, almost a quarter i.e. 25.8% neonates had hypocalcaemia that is considerably high percentage. So, infants born to diabetic mothers should be screened for hypocalcaemia to minimize the risk of related complications like seizure and loss of consciousness etc. Keywords: Pregnancy, diabetes mellitus, gestational diabetes mellitus, calcium level, hypocalcaemia

show abstract

Section: Introductionmentioning

confidence: 99%

Frequency of Hypocalcemia in Infants of Diabetic Mothers within 24 Hours of Life

Awan¹,

Abbas²,

Naz³

et al. 2023

PJMHS

View full text Add to dashboard Cite

show abstract

Effects of comprehensive nursing intervention on maternal and infant outcomes for gestational diabetes mellitus patients

Meng

2021

Int J Diabetes Dev Ctries

View full text Add to dashboard Cite

Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus

Subiabre

Silva

Villalobos-Labra

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

Pregnant women diagnosed with gestational diabetes mellitus subjected to diet (GDMd) that do not reach normal glycaemia are passed to insulin therapy (GDMi). GDMd associates with increased human cationic amino acid transporter 1 (hCAT-1)-mediated transport of L-arginine and nitric oxide synthase (NOS) activity in foetoplacental vasculature, a phenomenon reversed by exogenous insulin. Whether insulin therapy results in reversal of the GDMd effect on the foetoplacental vasculature is unknown. We assayed whether insulin therapy normalizes GDMd-associated foetoplacental endothelial dysfunction. Primary cultures of human umbilical vein endothelial cells (HUVECs) from GDMi pregnancies were used to assay L-arginine transport kinetics, NOS activity, p44/42 and protein kinase B/Akt activation, and umbilical vein rings reactivity. HUVECs from GDMi or GDMd show increased hCAT-1 expression and maximal transport capacity, NOS activity, and eNOS, and p44/42, but not Akt activator phosphorylation. Dilation in response to insulin or calcitonin-gene related peptide was impaired in umbilical vein rings from GDMi and GDMd pregnancies. Incubation of HUVECs in vitro with insulin (1 nmol/L) restored hCAT-1 and eNOS expression and activity, and eNOS and p44/42 activator phosphorylation. Thus, maternal insulin therapy does not seem to reverse GDMd-associated alterations in human foetoplacental vasculature.

show abstract

Complications in neonates of mothers with gestational diabetes mellitus receiving insulin therapy versus dietary regimen

Cited by 7 publications

References 17 publications

Frequency of Hypocalcemia in Infants of Diabetic Mothers within 24 Hours of Life

Frequency of Hypocalcemia in Infants of Diabetic Mothers within 24 Hours of Life

Effects of comprehensive nursing intervention on maternal and infant outcomes for gestational diabetes mellitus patients

Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus

Contact Info

Product

Resources

About