“…Also, the presence of ecchymosis (with greater intensity and extent) with prolonged discoloration causes post-inflammation hyperpigmentation (PIH), which can even create or intensify the black loop around the eye. 2,3 In clinical trials, various methods have been employed trying to reduce these side effects, which are summarized as employment of steroids, adrenaline solution one per 100,000, ice bag, intravenous tranexamic acid, clonidine, herbal material such as Arnica, and topical use of vitamins K. 4 Since the above agents are not impeccable either due to systemic effects or limitations in results of administration, if pharmacological agents can be used, which have easier and especially topical use and reduce effectively edema and ecchymosis, they can be routinely used in clinical settings. 4,5 Hirodoid (heparinoid or HPS) has anticlotting, fibrinolytic and anti-inflammatory effects, and until now, no study demonstrated the impact of hirodoid in reducing edema and ecchymosis following rhinoplasty, although other studies outside the field of surgery has been undertaken.…”