Complications in transcatheter aortic valve replacement: A comprehensive analysis and management strategies

Zou, Qi; Wei, Zhiliang; Sun, Shougang

doi:10.1016/j.cpcardiol.2024.102478

Current Problems in Cardiology

2024

DOI: 10.1016/j.cpcardiol.2024.102478

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Complications in transcatheter aortic valve replacement: A comprehensive analysis and management strategies

Qi Zou,

Zhiliang Wei,

Shougang Sun

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2024

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Cited by 4 publications

References 85 publications

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Transcatheter valvular therapy for aortic regurgitation with valvular structural variations

Li,

Ning,

Yan

et al. 2024

Asian Journal of Surgery

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Transcatheter valvular therapy for aortic regurgitation with valvular structural variations

Li,

Ning,

Yan

et al. 2024

Asian Journal of Surgery

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Letter to the Editor: Complications in transcatheter aortic valve replacement: A comprehensive analysis and management strategies

Khan,

Khan

2024

Current Problems in Cardiology

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Efficacy of Sentinel Cerebral Embolic Protection Device in Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Controlled Trials and Propensity Score-Matched Studies

Jain,

Pervez,

Dey

et al. 2024

Cardiology in Review

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Transcatheter aortic valve replacement (TAVR) is frequently associated with stroke due to debris embolization. Although the risk of stroke with newer-generation devices is lower, stroke still represents a significant cause of mortality and morbidity post-TAVR. The Sentinel cerebral embolic protection device (CEPD) is a dual-embolic filter device designed to capture debris dislodged during TAVR. A systematic literature search was performed on the major bibliographic databases to retrieve studies that compared TAVR with and without Sentinel CEPD. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the DerSimonian–Laird random-effects model, with a P value of <0.05 considered statistically significant. This meta-analysis included 6 studies with 25,130 patients undergoing TAVR (12,608: Sentinel CEPD; 12,522: without Sentinel CEPD). The use of the Sentinel CEPD in TAVR was associated with a statistically significant lower risk of acute kidney injury (OR: 0.89; 95% CI: 0.81–0.97; P = 0.01]. The use of Sentinel CEPD in TAVR was associated with a statistically insignificant trend toward a reduction in stroke (OR: 0.80; 95% CI: 0.58–1.10; P = 0.18), all-cause mortality (OR: 0.74; 95% CI: 0.51–1.07; P = 0.11), and major vascular complications (OR: 0.74; 95% CI: 0.46–1.19; P = 0.21). The use of Sentinel CEPD in patients undergoing TAVR does not lead to a statistically significant reduction in stroke, all-cause mortality, or major vascular complications; however, the risk of acute kidney injury is lower. Further randomized studies are warranted to confirm these findings.

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Complications in transcatheter aortic valve replacement: A comprehensive analysis and management strategies

Cited by 4 publications

References 85 publications

Transcatheter valvular therapy for aortic regurgitation with valvular structural variations

Transcatheter valvular therapy for aortic regurgitation with valvular structural variations

Letter to the Editor: Complications in transcatheter aortic valve replacement: A comprehensive analysis and management strategies

Efficacy of Sentinel Cerebral Embolic Protection Device in Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Controlled Trials and Propensity Score-Matched Studies

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