Complications of acute otitis media in children

Leskinen, Kimmo

doi:10.1007/s11882-005-0071-3

Cited by 29 publications

(19 citation statements)

References 41 publications

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“…However, as patient No. 2 did not receive ATRA before ear involvement, different mechanisms other than ATRA should also be explored: a lower vascularization of the mastoid as compared to the middle ear has been reported and justifies the frequent occurrence of mastoiditis as a complication of otitis treatment [9] due to a suboptimal concentration of antibiotics. The same mechanism could be involved in APL late relapse, with an inadequate local drug concentration.…”

Section: Discussionmentioning

confidence: 99%

Late Relapses in Acute Promyelocytic Leukaemia

Latagliata¹,

Carmosino²,

Breccia³

et al. 2006

Acta Haematol

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From January 1988 to December 1997, among 53 acute promyelocytic leukaemia patients in 1st complete remission (CR) after 5 years from diagnosis, we observed 5 late relapses (9.4%) after 60, 61, 71, 101 and 155 months from diagnosis; 3 of those late relapses (7.7%) occurred among 39 patients previously treated with all-trans-retinoic acid. An involvement of the mastoid occurred in 3/5 patients (60%), compared with 2/32 patients (6.3%) at an early relapse (p < 0.02). As to the treatment of the late relapse, 1 patient received all-trans-retinoic acid alone followed by allogeneic transplantation and 4 patients were treated according to the GIMEMA 0191 protocol. All patients achieved a 2nd CR and are still alive: 4 in the 2nd molecular CR after 6, 33, 34 and 115 months; 1 relapsed after 15 months and is now in the 3rd CR. In conclusion, a late relapse occurred in a sizeable fraction of acute promyelocytic leukaemia patients: the high rate of ear involvement might be explained considering the ear as a ‘disease sanctuary’.

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Section: Discussionmentioning

confidence: 99%

Late Relapses in Acute Promyelocytic Leukaemia

Latagliata¹,

Carmosino²,

Breccia³

et al. 2006

Acta Haematol

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“…When the infection in the mastoid compromises the integrity of the cortical layer of the mastoid, a subperiosteal abscess (SA) results. The most frequent location is retroauricular, less frequent is a Bezold's abscess where the infection propagates to the tip of the mastoid and Citelli's abscess where the extension is towards the occipital region [11].…”

Section: Extracranial Complications Acute Mastoiditismentioning

confidence: 99%

Otitis Media Complications

Martín

Fonseca

2015

Otitis Media: State of the Art Concepts and Treatment

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“…Entre os pacientes com OMA, a importância da antibioticoterapia decorre das complicações e seqüelas que podem ser estabelecidas quando a etiologia é bacteriana, a exemplo de mastoidite e surdez de condução 47 49 demonstraram que a resolução espontânea da OMA pode acontecer e está na dependência do agente etiológico: 48% para H. influenzae e 18% para S. pneumoniae. Uma recente meta-análise de 63 estudos demonstrou que os sintomas da OMA melhoram em 24 h sem uso de antibióticos em 61% das crianças (IC95% 50-72%), aumentando para 80% em 2 a 3 dias (IC95% 69-90%).…”

Section: Uso De Antibióticos Em Infecções De Vias Aéreasunclassified

Outpatient antibiotic therapy as a predisposing factor for bacterial resistance: a rational approach to airway infections

Nascimento‐Carvalho¹

2006

J Pediatr (Rio J)

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Objectives: To present evidence-based recommendations for the use of antibiotics for the treatment of the most common acute respiratory infections (ARI) and the available information on the importance of this type of management.Sources: MEDLINE and LILACS databases, technical publications by international organizations, national and international directives. The search terms acute respiratory infection, otitis, sinusitis, tonsillitis, pneumonia, antibiotic, guidelines and bacterial resistance were used. Articles cited by the articles selected were analyzed for information of interest.Summary of the findings: Bacterial resistance has grown, to the extent that today it is recognized as a global public health problem. ARI are the most common cause of antibiotic usage within the community; yet a large proportion of these cases, compromising the upper (otitis, sinusitis, tonsillitis) or the lower airways (pneumonia), are the result of viral infections. Recommendations to rationalize the use of antibiotics in patients with ARI have the common objective of minimizing unnecessary antibiotic use, since antibiotic pressure is one of the factors triggering bacterial resistance.Conclusions: It is of great importance to differentiate among ARI patients those who will benefit from the use of antibiotics. The establishment of recommendations for the prescription of antibiotics is one strategy for minimizing the frequency of bacterial resistance.J Pediatr (Rio J). 2006;82(5 Suppl):S146-52: Antibiotics, bacterial resistance, otitis, sinusitis, tonsillitis, pneumonia. ResumoObjetivos: Apresentar as recomendações baseadas em evidência para uso de antibióticos no tratamento das infecções respiratórias agudas (IRA) mais freqüentes e as informações disponíveis sobre a importância desse tipo de conduta.Fontes dos dados: Bases de dados MEDLINE, LILACS, publicações técnicas de organizações internacionais, diretrizes nacionais e internacionais. Foram utilizados os unitermos acute respiratory infection, otitis, sinusitis, tonsillitis, pneumonia, antibiotic, guidelines, bacterial resistance. Artigos citados pelos artigos incluídos foram analisados quanto à apresentação de informação de interesse. Síntese dos dados:A resistência bacteriana tem crescido, sendo atualmente reconhecida como problema mundial de saúde pública. As IRA são a causa mais freqüente para uso de antibiótico na comunidade; grande parte desses casos, tanto nas vias aéreas superiores (otite, sinusite, faringoamidalite) como nas inferiores (pneumonia), são decorrente de infecção viral. As recomendações para racionalizar o uso de antibióticos nos pacientes com IRA têm como objetivo comum minimizar o uso desnecessário de antibióticos, visto que a pressão antibióti-ca é um dos fatores desencadeantes da resistência bacteriana.Conclusões: É de grande importância a distinção, entre os pacientes com IRA, daqueles que podem se beneficiar do uso de antibióticos. O uso das recomendações para a prescrição de antibióticos é uma estratégia para minimizar a freqüência de resistên...

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Complications of acute otitis media in children

Cited by 29 publications

References 41 publications

Late Relapses in Acute Promyelocytic Leukaemia

Late Relapses in Acute Promyelocytic Leukaemia

Otitis Media Complications

Outpatient antibiotic therapy as a predisposing factor for bacterial resistance: a rational approach to airway infections

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