1982
DOI: 10.1111/j.1532-5415.1982.tb01362.x
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Complications of Alcohol Use Combined with Drug Therapy in the Elderly

Abstract: Chronic ingestion of ethanol in alcoholic beverages can impair drug therapy, lead to sometimes hazardous interactions, or compromise adherence to a well-planned drug treatment program. Various drugs consistently interact with alcohol: CNS depressants, such as benzodiazepines, barbiturates, muscle relaxants, antihistamines, and psychotropic agents; analgesics, including aspirin and narcotics; anticoagulants and other cardiovascular drugs, namely digitalis glycosides, diuretics, antihypertensives, and antiarrhyt… Show more

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Cited by 15 publications
(8 citation statements)
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“…The variety of OTC agents was determined by asking all subjects if they used aspirin, acetaminophen, laxatives, antacids, vitamins, cold medicines, ibuprofen, diarrhea medicines, allergy medicines, nausea medicines, sleeping medicines, nerve medicines, alcohol, nicotine, caffeine-containing beverages, or other unlisted medications obtained without a doctor's prescription. Caffeine, alcohol, and nicotine were included because they have pharmacologic effects, have documented potential for adverse interaction with prescription and nonprescription medications, and affect chronic diseases common among older adults, such as cardiovascular diseases and diabetes (Gerbino, 1982;Shimp et al, 1985).…”
Section: Instrumentsmentioning
confidence: 99%
“…The variety of OTC agents was determined by asking all subjects if they used aspirin, acetaminophen, laxatives, antacids, vitamins, cold medicines, ibuprofen, diarrhea medicines, allergy medicines, nausea medicines, sleeping medicines, nerve medicines, alcohol, nicotine, caffeine-containing beverages, or other unlisted medications obtained without a doctor's prescription. Caffeine, alcohol, and nicotine were included because they have pharmacologic effects, have documented potential for adverse interaction with prescription and nonprescription medications, and affect chronic diseases common among older adults, such as cardiovascular diseases and diabetes (Gerbino, 1982;Shimp et al, 1985).…”
Section: Instrumentsmentioning
confidence: 99%
“…Noncompliance and polypharmacy frequently have been documented in the elderly, and adverse drug reactions are common 7–10 . Debilitating illnesses, perceptual deficiencies, and alcohol abuse are additional perturbing influences 11–14 . These various potentially deleterious factors, combined with burgeoning numbers of elderly, heighten the urgency of investigations in this arena.…”
mentioning
confidence: 99%
“…Additive effects of acute alcohol consumption may occur, because acute alcohol consumption may increase the blood levels and CNS effects of tricyclic antidepressants 96 . All of the benzodiazepines, when taken with ethanol, have an increased central nervous system depressive effect 97 . In the case of the phenothiazines, increased ethanol blood levels have been reported after their concomitant administration, and there may be an increased risk of extrapyramidal reactions in the presence of ethanol 97 …”
Section: Interactions Of Alcohol and Drugs Commonly Used In The Elderlymentioning
confidence: 99%
“…Thus, the concurrent use of these drugs should be contraindicated. Antihistamines, likewise, frequently are sedating and in the presence of alcohol can have additive effects and produce hazardous conditions for the elderly 97 …”
Section: Interactions Of Alcohol and Drugs Commonly Used In The Elderlymentioning
confidence: 99%
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