Complications of an implantable venous access device (Port-a-Cath®) during intermittent continuous infusion of chemotherapy

Poorter, R.L.; Lauw, Fanny N.; Bemelman, W. A.; Bakker, Piet; Taat, C. W.; Veenhof, C. H. N.

doi:10.1016/s0959-8049(96)00274-2

Cited by 116 publications

(74 citation statements)

References 11 publications

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“…In our study, it was not possible to compare the incidence of immediate complications between puncture in the subclavian vein to those in the jugular vein, given that patients who had pneumothorax or hemothorax underwent puncture attempts in both veins. The incidence of pneumothorax found in the present study (1.2%), however, was within the range of 1-6% reported in the literature [4,10,[12][13][14]19,24,25,[27][28][29]. The incidence of hematoma in the puncture site, which was 1.2% in our study, has been previously described as ranging from 0.8 to 8% [14,19,29,30].…”

Section: Discussionsupporting

confidence: 73%

“…No cases of clavicular pain or stenosis of the subclavian vein were observed. The incidence of thrombosis among adult patients normally ranges from 0.3 to 28% [1,10,13,14,16,29], while among children it is around 12% [32]. However, in our study, thrombosis was diagnosed by chest tomography in just one asymptomatic patient in the subclavian vein group (1.2%), which was later confirmed by phlebography.…”

Section: Discussioncontrasting

confidence: 62%

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Long‐term complications in totally implantable venous access devices: Randomized study comparing subclavian and internal jugular vein puncture

Ribeiro

Abib

Aguiar

et al. 2011

Pediatric Blood & Cancer

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BackgroundThis prospective randomized study evaluated complications related to long‐term totally implantable catheters in oncologic children and adolescents by comparing venopunction performed either in the jugular or subclavian vein.MethodsA total of 83 catheters were implanted from January 2004 to April 2006 and followed‐up until March 2008. Patients were randomly allocated to the subclavian or jugular vein group. The endpoint was complications that led to catheter revision or catheter removal.ResultsSix patients were excluded, 43 had the catheter implanted in the subclavian and 34 in the jugular vein. Subclavian catheters were used for up to 12.6 months, while jugular catheters were kept in place for up to 14.8 months (P = 0.38). No statistical differences were found between the groups concerning age, sex, leukocyte count, platelet count, type of admission (in or outpatient), or previous chemotherapy regimens. When analyzed individually, long‐term complications did not present statistically significant differences either. Infection occurred in 20 and 11% (P = 0.44), while catheter embolism took place in 23 and 8% (P = 0.11) of patients with subclavian and jugular catheters, respectively. A statistical difference was seen in the total number of complications, which occurred in 48 and 23% (P = 0.02) of patients in the subclavian and in the jugular groups, respectively.ConclusionsCatheters implanted by puncture in the subclavian vein were more prone to late complications than those implanted in the jugular vein. Pediatr Blood Cancer 2012; 58: 274–277. © 2011 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 73%

Section: Discussioncontrasting

confidence: 62%

Long‐term complications in totally implantable venous access devices: Randomized study comparing subclavian and internal jugular vein puncture

Ribeiro

Abib

Aguiar

et al. 2011

Pediatric Blood & Cancer

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“…There is wide variation in the rates reported in the literature. Thrombosis rates of less than 5% have been reported for patients with implanted access ports managed with heparin flushes [14][15][16]. In a series of 92 patients with implanted devices managed with heparin flushes and, in high-risk patients, a low-dose oral anticoagulant, Lokich et al reported a 16% thrombosis rate, which they contrasted with the 43% thrombosis rate in a previous series of patients with tunneled subclavian catheters [17].…”

Section: Venous Thrombosis In Cancer Patientsmentioning

confidence: 97%

Venous Thrombosis in Cancer Patients: Insights from the FRONTLINE Survey

et al. 2003

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Background. Venous thromboembolism (VTE) is a common complication in cancer patients and a significant cause of morbidity and mortality. However, little information is available on oncologists' perceptions of the risk of VTE and its management. The Fundamental Research in Oncology and Thrombosis (FRONTLINE) study is the first comprehensive global survey of thrombosis and cancer. The study was designed to collect data on the perceived risk and patterns of practice with regard to VTE in cancer patients undergoing surgical and medical management of their malignancy and to provide information on international and regional practice patterns, allowing for the design of research studies to answer the concerns of practicing clinicians.Methods. Literature reviews were performed to provide a current evidence base against which to compare the findings, and a survey was developed under the guidance of an advisory board. A paper-based replypaid questionnaire was distributed globally between July and November 2001 to clinicians involved in cancer care and was made available on a dedicated website.Findings. A total of 3,891 completed responses were available for analysis. Brain and pancreatic tumors were considered to carry a high risk for VTE, and 80% of respondents considered the use of central venous lines to be associated with a high risk of VTE. Marked differences were seen in the use of thromboprophylaxis for

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“…Some chemotherapeutic agents are notorious for causing thrombophlebitis or extravasations injuries. With a central line, all these complication can be reduced [1,14]. Since the introduction of TIVAPs, many studies have been published regarding their efficacy, cost, and complications [1].…”

Section: Discussionmentioning

confidence: 99%

Use of port-a-cath in cancer patients: a single-center experience

Dsouza

Kumar

Kakaria

et al. 2014

J Infect Dev Ctries

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Introduction: Central venous catheters play an important role in the management of cancer patients. Different types of devices are associated with different patterns of complications. We report on the pattern of use and rate of complications of port-a-caths in patients diagnosed with malignant cancer at a single institution. Methodology: The data were collected retrospectively from patients who received the treatment for solid tumors or lymphoma through a porta-cath at the Sultan Qaboos University Hospital (SQUH) between January 2007 and February 2013. Results: A total of 117 port-a-caths were inserted in 106 patients. The majority (86; 73.5%) were implanted by an interventional radiologist, and the right internal jugular vein was accessed in 79 (67.5%) patients. Mean catheter indwelling time was 354 (range 3-1,876) days for all patients, 252 (3-1,876) and 389 days (13-1,139) for patients with and without complications, respectively. Thirty (25.6%) port-a-caths were removed prematurely, mainly due to infectious complications, while 17 (14.5%) were removed after completion of treatment. Staphylococcus aureus was the most frequently isolated organism, found in 8 (6.8%) patients. Underlying diagnosis (p < 0.001), chemotherapy regimen (p < 0.001), sensitivity to antibiotics (p = 0.01), and any complication (p < 0.001) were significant factors affecting the duration of port-a-cath use. None of these factors were significant on multivariate cox regression analysis. Conclusions: The mean duration of port-a-cath use was almost one year. Infection was the most common complication leading to premature removal, followed by port thrombosis.

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Complications of an implantable venous access device (Port-a-Cath®) during intermittent continuous infusion of chemotherapy

Cited by 116 publications

References 11 publications

Long‐term complications in totally implantable venous access devices: Randomized study comparing subclavian and internal jugular vein puncture

Long‐term complications in totally implantable venous access devices: Randomized study comparing subclavian and internal jugular vein puncture

Venous Thrombosis in Cancer Patients: Insights from the FRONTLINE Survey

Use of port-a-cath in cancer patients: a single-center experience

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