Complications of Carbon Dioxide Laser Resurfacing. An Evaluation of 500 Patients

Nanni, Christopher A.; Alster, Tina S.

doi:10.1111/j.1524-4725.1998.tb04161.x

Cited by 376 publications

(361 citation statements)

References 19 publications

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“…The induced thermal shock stimulates fibroblasts to produce new collagen, which is arranged in a more ordered fashion with respect to the old one, thus reducing wrinkles. In such a treatment, a significant amount of skin is completely ablated, giving rise to a long wound healing time with some related risks of persistent redness, infection, and scarring [9][10]. A possible way to overcome these side effects is represented by micro-ablative fractional laser resurfacing [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

In vivo non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing

Cicchi

Kapsokalyvas²,

Troiano

et al. 2013

Journal of Biophotonics

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Journal of BIOPHOTONICSNon-linear optical microscopy is becoming popular as a non-invasive in vivo imaging modality in dermatology. In this study, combined TPF and SHG microscopy were used to monitor collagen remodelling in vivo after microablative fractional laser resurfacing. Papillary dermis of living subjects, covering a wide age range, was imaged immediately before and forty days after treatment. A qualitative visual examination of acquired images demonstrated an age-dependent remodelling effect on collagen. Additional quantitative analysis of new collagen production was performed by means of two image analysis methods. A higher increase in SHG to TPF ratio, corresponding to a stronger treatment effectiveness, was found in older subjects, whereas the effect was found to be negligible in young, and minimal in middle age subjects. Analysis of collagen images also showed a dependence of the treatment effectiveness with age but with controversial results. While the diagnostic potential of in vivo multiphoton microscopy has already been demonstrated for skin cancer and other skin diseases, here we first successfully explore its potential use for a non-invasive follow-up of a laser-based treatment.Three-dimensional projection of a stack of 20 SHG images acquired within dermis of a healthy subject. Volume shown: 400 Â 400 Â 100 mm 3 .

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Section: Introductionmentioning

confidence: 99%

In vivo non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing

Cicchi

Kapsokalyvas²,

Troiano

et al. 2013

Journal of Biophotonics

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“…With the selection of appropriate parameters, however, the biophysics of CO 2 and Er:YAG laser -tissue interaction creates similar injuries and cosmetic results [4][5][6][7]. Conceivably, the shortcomings of both methods are very similar: while they produce clinically efficacious results, the intensity and depth of the thermal injury may require anesthesia and result in unwanted effects such as hypo-or hyperpigmentation, prolonged wound healing and even scarring [1,6,8,9]. Extended downtime and long lasting side effects are obvious drawbacks for patients undergoing these procedures.…”

Section: Introductionmentioning

confidence: 99%

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

et al. 2010

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Background and Objective: Ablative fractional lasers were introduced for treating facial rhytides in an attempt to achieve results comparable to traditional ablative resurfacing but with fewer side effects. However, there is conflicting evidence on how well this goal has generally been achieved as well as on the comparative value of fractional CO 2 and Er:YAG lasers. The present study compares these modalities in a randomized controlled double-blind split-face study design. Study Design/Materials and Methods: Twenty-eight patients were enrolled and completed the entire study. Patients were randomly assigned to receive a single treatment on each side of the peri-orbital region, one with a fractional CO 2 and one with a fractional Er:YAG laser. The evaluation included the profilometric measurement of wrinkle depth, the Fitzpatrick wrinkle score (both before and 3 months after treatment) as well as the assessment of side effects and patient satisfaction (1, 3, 6 days and 3 months after treatment). Results: Both modalities showed a roughly equivalent effect. Wrinkle depth and Fitzpatrick score were reduced by approximately 20% and 10%, respectively, with no appreciable difference between lasers. Side effects and discomfort were slightly more pronounced after Er:YAG treatment in the first few days, but in the later course there were more complaints following CO 2 laser treatment. Patient satisfaction was fair and the majority of patients would have undergone the treatment again without a clear preference for either method. Conclusions: According to the present study, a single ablative fractional treatment session has an appreciable yet limited effect on peri-orbital rhytides. When fractional CO 2 and Er:YAG lasers are used in such a manner that there are comparable post-operative healing periods, comparable cosmetic improvement occurs. Multiple sessions may be required for full effect, which cancels out the proposed advantage of fractional methods, that is, fewer side effects and less down time.

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“…Although invasive procedures such as facelifts can achieve skin tightening quickly, they do not rejuvenate the skin and subcutaneous tissues and are accompanied with prolonged downtime and potential adverse effects. Ablative procedures such as traditional skin resurfacing with CO 2 laser devices are also effective for skin tightening, however they are associated with extended recovery time, bleeding, oozing, and risk of post-treatment hyper-or hypopigmentation [1,2]. In addition, laser treatments can be very problematic for treating darker skin types or sensitive Asian skin.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Tanaka¹

2018

Dermatologic Surgery and Procedures

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Regardless of age, sex and skin type, skin tightening is a common procedure requested by patients seeking cosmetic treatments to improve facial contours and skin laxity. Radiofrequency has been proven to penetrate deeper than optical light sources independent of skin color and to be beneficial for skin tightening. I previously reported on the efficacy of multisource phase-controlled radiofrequency treatment and noninsulated microneedle radiofrequency applicator with fractionated pulse mode. The evaluation process was both subjective and objective; I evaluated objectively using threedimensional color schematic representation with quantitative volume measurements. These three-dimensional results showed significant improvement after the treatments. The post-treatment volume was drastically reduced as compared to the pretreatment volume. Most of the patients reported satisfaction with the improvement of skin laxity. The advantages of these multisource phase-controlled radiofrequency treatments are their long-lasting high efficacy of tightening effects, and the reduction of discomfort and side effects. These characteristics facilitate repeated treatments as well as provide safe and effective treatment of skin tightening.

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Complications of Carbon Dioxide Laser Resurfacing. An Evaluation of 500 Patients

Abstract: Cutaneous CO2 laser resurfacing is a relatively safe procedure with a low complication profile. Proper laser treatment protocol and postoperative management is important in reducing side effects and complications.

Cited by 376 publications

References 19 publications

In vivo non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing

In vivo non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

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Complications of Carbon Dioxide Laser Resurfacing. An Evaluation of 500 Patients

Abstract: Cutaneous CO2 laser resurfacing is a relatively safe procedure with a low complication profile. Proper laser treatment protocol and postoperative management is important in reducing side effects and complications.

Cited by 376 publications

References 19 publications

In vivo non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing

In vivo non‐invasive monitoring of collagen remodelling by two‐photon microscopy after micro‐ablative fractional laser resurfacing

Ablative fractional lasers (CO2 and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

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Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides