Complications of CSF Shunting in Hydrocephalus

Rocco, Concezio Di; Turğut, Mehmet; Jallo, George I.; Martínez‐Lage, Juan F.

doi:10.1007/978-3-319-09961-3

Cited by 17 publications

(4 citation statements)

References 26 publications

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“…An increase in the treatment effectiveness under VSS is achieved by restoring intracranial circulation and CSF absorption at the stage of prolonged sanitation of craniospinal CSF spaces with saline solution in combination with VSGD and LP. There is a high percentage of dysfunction and complications after VPS [6][7][8][9][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…At present, much attention is paid to the study of posthemorrhagic hydrocephalus in newborns [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. It is noted that the formation of hydrocephalus is due to direct occlusion of the cerebrospinal fluid by blood clots, or dynamic occlusion by means of the subarachnoid space (SAS) compression, impaired absorption of cerebrospinal fluid (CSF) with indications, at the initial stage, for lumbar punctures (LP), ventricular punctures (VP) with 20-22G needles, as well as puncture drainage of the lateral ventricles [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…LP-VSGD-VPS). The relevance of the problem is that there is no generally accepted opinion regarding the treatment of decompensated hydrocephalus [6][7][8] with the need to personalize treatment tactics aimed at restoring CSF dynamics [2], reducing the incidence of VPS and system dysfunction [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Posthemorrhagic Hydrocephalus With Decompensation Of Cerebrospinal Fluid Dynamics In Newborns: New In Treatment Tactics

2020

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Background ― Posthemorrhagic hydrocephalus in newborns with occlusion of cerebrospinal fluid leads to decompensation of cerebrospinal fluid dynamics. There is no single method that meets all the criteria for the effectiveness and safety of treatment. The study goal was to investigate the use of coronary translambdoid subarachnoid ventriculostomy (CTSV) and ventricular subarachnoid stenting (VSS) in the treatment of neonatal hydrocephalus. Material and Methods ― The analysis of the posthemorrhagic hydrocephalus treatment in 327 newborns for the period of 2000-2018 in Crimea. Two groups have been identified. In the Group 1, 184 children underwent standard treatment according to the ‘LVV protocol’ with lumbar and ventricular punctures with 20-22G needles, while with progression of hydrocephalus, with ventriculosubgaleal drainage and ventriculoperitoneal shunt. In 143 children with occlusion and ventricular block, the treatment complex included CTSV – RF Patent No. 2715535, and ventricular drainage by the ventricular subarachnoid stenting (VSS) – RF Patent No. 2721455. Results ― An increase in the treatment radicality under CTSV is achieved through the use of the cerebral needles of a larger diameter (14G) and puncture access zones, elimination of occlusion, while under VSS, restoration of intracranial circulation and absorption of cerebrospinal fluid is ensured by prolonged sanitation with a saline solution of cerebrospinal fluid spaces. A positive outcome with compensation for hydrocephalus was achieved in 75.4% of cases versus 28.2% under the conventional protocol (p<0.001). In other cases, the imbalance of production and absorption of cerebrospinal fluid remained, which required the integration of the VSS with the peritoneal segment of the shunt, without further replacement and reinstallation of the system. Conclusion ― Our results allow us to consider the effectiveness of CTSV and VSS inclusion in the contemporary algorithm for the treatment of decompensated posthemorrhagic hydrocephalus in newborns.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Posthemorrhagic Hydrocephalus With Decompensation Of Cerebrospinal Fluid Dynamics In Newborns: New In Treatment Tactics

2020

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“…In infants, hydrocephalus is a challenging condition caused by developmental and/or acquired obstruction of CSF flow that leads to progressive enlargement of brain ventricles [2, 4, 7, 17]. In a previous experiment using autoradiography, Aggelopoulos et al [30] reported that newborn rats with inherited prenatal hydrocephalus demonstrated an abnormality in the distribution of melatonin receptors posterior to the cerebral aqueduct compared to control animals.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalus

2018

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Objective/Aim: Hydrocephalus is defined as an incapacitating neurological disorder characterized by ventricular enlargement in children, but the effects of melatonin on this hydrocephalus have not yet been fully elucidated. In the present experiment, we attempted to investigate the effects of exogenous melatonin administration on hydrocephalus-induced hippocampal changes in infantile rats. Methods: In this study, we randomly divided 45 Swiss albino rats aged 2 weeks into 3 groups: group I, the control group received a sham injection with needle insertion only; groups II and III were given kaolin injections before treatment – group II, the hydrocephalus group, was treated with an isotonic NaCl solution, and group III, the hydrocephalus plus melatonin group, was treated with 0.5 mg/100 g body weight of exogenous melatonin. Both immunohistochemical and histological analyses were performed after hydrocephalus induction and melatonin administration. Immunohistochemical staining consisted anti-glial fibrillary acidic protein staining. The TUNEL technique was used for defining quantitate apoptosis. Results: Melatonin administration significantly attenuated chronic hydrocephalus-induced histopathological changes in the hippocampal subregions of infantile rats. Compared to hydrocephalic rats treated with saline solution, melatonin significantly decreased the number of apoptotic cells and pyknotic index values of each hippocampal subregion after the kaolin-induced hydrocephalus (p < 0.001). Conclusion: The present results demonstrate that the chronic hydrocephalus-induced histopathological changes in the hippocampus were partially reversible with melatonin treatment, suggesting its neuroprotective effects in infantile rats. However, these findings need to be confirmed by further experimental studies and clinical trials.

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Hydrocephalus Associated to Tumors

Beltagy

2017

Textbook of Pediatric Neurosurgery

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Complications of CSF Shunting in Hydrocephalus

Cited by 17 publications

References 26 publications

Posthemorrhagic Hydrocephalus With Decompensation Of Cerebrospinal Fluid Dynamics In Newborns: New In Treatment Tactics

Posthemorrhagic Hydrocephalus With Decompensation Of Cerebrospinal Fluid Dynamics In Newborns: New In Treatment Tactics

Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalus

Hydrocephalus Associated to Tumors

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