Complications of Diabetes 2017

Παπαθεοδώρου, Κωνσταντίνος; Banach, Maciej; Bekiari, Eleni; Rizzo, Manfredi; Edmonds, Michael

doi:10.1155/2018/3086167

Cited by 495 publications

(373 citation statements)

References 11 publications

Supporting

Mentioning

349

Contrasting

Unclassified

Order By: Relevance

“…There are two types of DM; Type I DM in which the pancreatic beta cells do not produce insulin and Type II DM in which insulin is produced insufficient levels or it is not fully utilized by cells. Both types of DM are accompanied by major chronic complications, including microvascular complications such as neuropathy, nephropathy, and retinopathy, as well as undefined body weight loss [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, diabetic nephropathy causes several metabolic alterations, change in blood circulation, generation of abundant reactive oxygen species (ROS) and nitrogen species, in addition to excess production of inflammatory cytokines or C-reactive protein [6][7][8]. The elevation in such inflammatory markers might act as risk factors for developing diabetic complications in the chronic condition [9], particularly in the pathogenesis of diabetic nephropathy [3]. Hyperglycemia is the major risk factor for diabetic nephropathy through the formation of advanced glycation end products that promote the production of redundant ROS [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress

et al. 2020

View full text Add to dashboard Cite

Background: Diabetes mellitus is a global epidemic leads to multiple serious health complications, including nephropathy. Diabetic nephropathy is a serious kidney-related complication of type 1 or 2 diabetes that is prevalent in almost 40% of the people with diabetes. We examined whether folic acid and melatonin can reduce progression of nephropathy in rats of type 1 diabetes mellitus by controlling the level of oxidative stress, glucose, lipids, and cytokines. Methods: Forty-two male albino rats were distributed into six groups, (n = 7 per group). Five of the groups were induced with diabetes by a single intraperitoneal injection of freshly prepared streptozotocin at a dose of 50 mg/kg body weight. After the induction of diabetes, the rats were treated with folic acid (100 mg/kg) and melatonin (10 mg/kg) separately and in combination daily for 6 weeks, whereas, the other diabetic group was treated with glibenclamide (5 mg/kg). One of the diabetic groups served as a positive control. One-way ANOVA was used to compare those five subfields ability followed by LSD multiple comparisons. Results: The data indicated that diabetes significantly altered the body weight, lipids and kidney function. Diabetic rats exhibited a significant increase in plasma levels of urea, uric acid, creatinine, sodium, tumor necrosis factor alpha (TNF-α), interleukin-6(IL-6), cholesterol, triglycerides, and low-density lipoprotein (LDL). In contrast, plasma total protein, potassium, high-density lipoprotein (HDL) and interleukin-10 (IL-10) decreased significantly in diabetic rats compared to the control rats. Moreover, levels of renal malondialdehyde (MDA) and nitric oxide (NO) were significantly increased while the levels of renal glutathione(GSH), superoxide dismutase(SOD), and catalase (CAT) were significantly decreased in diabetic rats comparison to those in the control rats. Hence, diabetic rats treated with folic acid and melatonin alone as well as in combination showed improvements with respect to the indices in addition to a significant recovery observed via histopathology when compared to the diabetic group. Conclusions: These results revealed that treatment with folic acid in combination with melatonin in diabetic rats was more effective than treatment with either of folic acid or melatonin alone to alleviate the symptoms of diabetic nephropathy.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[15][16] Al comorbidities were evaluated by a multidisciplinary team like appears in some bibliographies. [17][18][19] In our opinion the extension of diabetic foot treatment to primary health care is highly satisfactory if the personnel is previously educated and checked closely.…”

Section: Discussionmentioning

confidence: 89%

The use of recombinant epidermal growth factor in primary health assistance

Risco¹

2018

HPMIJ

View full text Add to dashboard Cite

Introduction:The high morbidity for diabetic foot and its long hospitalization could be solved with the same quality thanks to the level achieved by the Cuban National Health System as well as the proved efficacy of Recombinant Epidermal Growth Factor (EFG) (Heberprot-P) and the training of the personnel who work in the welfare health areas.Objective: To Evaluate the diabetic foot treatment using Heberprot-P in the primary health assistance in Cuba.Patients & method: Our universe was composed by 1551patients assisted consecutively in four welfare health areas. All of them received 15 to 24 intralesional injections of 75micrograms each, three times a week. They were under went to surgical operations when required under nerve trunk anesthesia on the leg. An informed consent was signed previously. The variables analyzed were: Age, sex, Wagner classification, doses administered, surgical procedures and final result. Results:In our series 407 debridement were carried out (26%), 77 toe amputations (4, 96 %) and 3 metatarsal amputations (0, 19%). No major amputations were carried out. A satisfactory granulation was achieved in all patients. The adverse reactions were 17 (1, 1%) all of them were mild. Nobody quit the treatment and there were no mortality. Conclusions:Among our patients the treatment were 100% effective the rate of amputations were low. The adverse events were few and mild.

show abstract

“…Diabetes mellitus (DM) [1] is one of the major public health concerns, forthcoming epidemic proportions worldwide. Current global estimates indicate that DM currently affects over 425 million people worldwide, and this number is expected to increase to 642 million by the year 2040 [2].…”

Section: Introductionmentioning

confidence: 99%

Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

et al. 2020

View full text Add to dashboard Cite

Diabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily focused on hyperglycemia as a key player in the pathophysiology of diabetic complications, recently, increasing evidence have underlined the role of adipose inflammation in modulating the development and/or progression of diabetic kidney disease. This review focuses on how adipose inflammation contribute to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose inflammation and its impact on diabetic kidney disease highlights the need for novel interventions in the treatment of diabetic complications.

show abstract

Complications of Diabetes 2017

Cited by 495 publications

References 11 publications

Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress

Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress

The use of recombinant epidermal growth factor in primary health assistance

Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

Contact Info

Product

Resources

About