Complications of IV sedation for dental treatment in individuals with intellectual disability

Complications associated with intravenous midazolam and fentanyl sedation in patients undergoing minor oral surgery

“…However, our study was limited by the small sample size, and further studies with larger samples including different types of patients and procedures will strength our results and enable the clinical application of our findings with greater confidence. No serious complication was observed in the present study, similar to findings in previous studies [ 7 8 9 10 11 ].…”

“…Wilson et al [ 7 ] reported a complication rate of 3% in anxious dental patients sedated with intravenous midazolam, while Rodgers et al [ 8 ] reported a rate of 1.57% for patients who underwent oral surgery under intravenous sedation. Furthermore, Inverso et al [ 9 ] reported a complication rate of 0.5% for patients who underwent third molar extraction surgery under moderate sedation, Sanel et al [ 10 ] reported a rate of 1.4% for patients who underwent oral and maxillofacial surgery under intravenous sedation with midazolam and fentanyl, and Kouchaji [ 11 ] reported a postoperative complication rate of 25% in individuals with intellectual disability who underwent dental treatment under intravenous sedation with propofol. The sedation-related complication rate observed in our study was somewhat higher than these previous rates.…”

“…While midazolam is a benzodiazepine with sedative and hypnotic qualities, the ability to cause powerful amnesia, and a short half-life, fentanyl is an opioid analgesic. However, moderate intravenous sedation is not without complications, with the reported incidence ranging from 0.5% to 25% depending on the type of medications used and their dosage, the type of patient, the procedure being performed, and the preferred level of sedation [ 7 8 9 10 11 ].…”

Determining a Safe Time for Oral Intake Following Pediatric Sedation

“…The report on minor side effects is lacking [14]. In a study investigating the complications of intravenous sedation in intellectually disabled patients undergoing dental treatments, the author reported no nausea and vomiting with propofol sedation in the recovery period, similar to another study investigating propofol efficiency in sedation during intracarotid sodium amobarbital procedures (Wada test) [15,16]. However, there is no information about the first oral intake time of the patients or the period after their discharge in either study.…”