Complications of kidney transplantation with grafts from expanded criteria donors

Barba, J.; Zudaire, J.J.; Robles, J.E.; Rosell, D; Berián, J.M.; Pascual, Ignacio

doi:10.1007/s00345-012-0831-3

Cited by 22 publications

(22 citation statements)

References 28 publications

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“…Furthermore, a study by Frezza et al [96] observed that in a long-term outcome after kidney transplantation, Glucocorticoids (GCs) resistant patients showed higher incidence of acute rejection episodes, lower acute rejection-free survival, poor response of acute rejection treatment, as well as higher incidence of renal allograft loss. However, no difference was found regarding patient mortality, wound, and vascular complications [63]. Moreover, greater frequency of more severe surgical complications and lower graft survival has been reported [63].…”

Section: Consequencesmentioning

confidence: 99%

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Factors Contributing to Kidney Allograft Loss and Associated Consequences among Post Kidney Transplantation Patients

Ndemera¹,

Bhengu²

2017

Health Sci J

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Section: Consequencesmentioning

confidence: 99%

“…Nemati and Taghipour [24], Barba et al [62] support that expanded criteria donors may be risk factors to graft failure. Reese et al [63] defined expanded criteria as donors who are greater than 50 years with at least hypertension history, serum creatinine >1.5 mg/dl or cause of death from cerebrovascular accident.…”

Section: Donor Related Factorsmentioning

confidence: 99%

Factors Contributing to Kidney Allograft Loss and Associated Consequences among Post Kidney Transplantation Patients

Ndemera¹,

Bhengu²

2017

Health Sci J

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“…Aging of the donors directly impacts on long-term graft survival, and, in a recent series, among 407 KTs, graft survival was significantly lower for the ECD when compared to the non-ECD (5-year survival rate: 74% versus 90%, < 0.001) [21]; the older the donor, the greater seems to be the decrease in survival [6]. A similar correlation between age and graft outcome has been described in living donor KT [28].…”

Section: The ''Marginal Donors''mentioning

confidence: 96%

“…The risk of graft failure (e.g., return to maintenance dialysis or graft nephrectomy) is more frequent in marginal donor kidney recipients [6,16,17], as largely documented in recently published series [20][21][22][23][24][25][26][27] (Table 1). Aging of the donors directly impacts on long-term graft survival, and, in a recent series, among 407 KTs, graft survival was significantly lower for the ECD when compared to the non-ECD (5-year survival rate: 74% versus 90%, < 0.001) [21]; the older the donor, the greater seems to be the decrease in survival [6].…”

Section: The ''Marginal Donors''mentioning

confidence: 99%

Expanded Criteria Donors in Kidney Transplantation: The Role of Older Donors in a Setting of Older Recipients

Rosa

Muscogiuri

Sarno

2013

ISRN Transplantation

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Kidney transplantation (KT) is the therapy of choice for end-stage renal disease (ESRD). The ESRD population is aging and so are patients waiting for KT. New strategies have been made for increasing the donor and recipient pools, and as a consequence kidneys from older donors or donors with significant comorbidities, the so-called "expanded criteria donor" (ECD) kidneys, are used for transplantation. Although good outcomes have been achieved from ECD, several issues are still waiting for clarification and need to be discussed. The concept of age matching is accepted as a method to ameliorate utilization of these allografts, but an optimal and widely accepted strategy is still not defined. The development of machine perfusion and the dual kidney transplantation are techniques which further improve the outcome of transplants from ECD, but the described experiences are scarce or coming from small single institutional reports. Also due to age-related immune dysfunction and associated comorbidities, the elderly recipients are more susceptible to immunosuppression related complications (e.g., infections and malignancy), although a widely accepted and validated immunosuppressive regimen is still lacking. In this paper, we review the issues related to KT employing allografts from marginal donors with a particular interest for the elderly patients.

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“…Thus, donor kidneys from diverse sources including the ECDs are received and transplanted [3]. However, reports indicate that kidneys sourced from ECDs are characterized by post-transplant complications such as acute rejection episodes, primary nonfunction, greater rate of delayed graft function (DGF) and greater frequency of graft failure [4]. The cold-storage and machine perfusion (MP) are two commonly employed techniques for the preservation of kidneys before transplantation [5].…”

Section: Introductionmentioning

confidence: 99%

Potential applications of lipid peroxidation products in renal transplantation

Erejuwa¹,

Sulaiman²,

Wahab³

2013

Transplant Technol

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There has been an increased prevalence of end-stage renal disease (ESRD) in the last decades. This can be attributed to high incidence of chronic diseases such as metabolic disorders, diabetes and hypertension. These diseases are often associated with ESRD, which requires regular dialysis and may later necessitate renal transplantation. The increased demand for renal transplantation has resulted in scarcity of donor kidneys leading to receipt of kidneys from extended criteria donors (ECDs) whose kidneys are susceptible to ischemic-injury. The levels of lipid peroxidation products, which are biomarkers of oxidative stress and damage, have been reported to be elevated in ischemic-injury. Therefore, transplantation of kidneys prone to ischemic-injury poses a great danger or high rate of failure in the recipients. The aim of this mini review is to highlight the potential usefulness or application of lipid peroxidation products in screening donor kidneys for renal transplantation. As a result of machine perfusion (MP), it is now possible to determine certain biomarkers such as lipid peroxidation products in the perfusate which reveal kidneys that have undergone severe ischemic and/or oxidative damage. This will help in screening or identification of kidneys that are unfit for transplantation. Besides, lipid peroxidation products can also be used to monitor or evaluate patient's post-transplant recovery. Thus, measurement of lipid peroxidation products may help to reduce post-transplant failure and improve the quality of life of recipients.

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Complications of kidney transplantation with grafts from expanded criteria donors

Abstract: Transplantation of kidneys from expanded criteria donors is associated with a significant higher risk of medical and surgical complications than kidneys from non-expanded criteria donors.

Cited by 22 publications

References 28 publications

Factors Contributing to Kidney Allograft Loss and Associated Consequences among Post Kidney Transplantation Patients

Factors Contributing to Kidney Allograft Loss and Associated Consequences among Post Kidney Transplantation Patients

Expanded Criteria Donors in Kidney Transplantation: The Role of Older Donors in a Setting of Older Recipients

Potential applications of lipid peroxidation products in renal transplantation

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