Background. Risk factors of postoperative complications during percutaneous nephrolithotomy (PCNL) include stone burden, the preoperative microbiological status of urine, comorbidity, age, operative time, intraoperative level of sterility, and antibiotic prophylaxis. The study aimed to assess the sequelae of these complications. Materials and methods. This retrospective study was conducted on patients treated by PCNL under fluoroscopic guidance for a one-year duration. The demographic data, body mass index, stone burden, stone density, number, duration of surgery, and postoperative complications were recorded. Results. Out of 50 patients, 32 (64 %) developed a fever. White blood cell count was significantly high among those patients. The age of the patients, gender, body mass index, and hospital stay were insignificant variables. Stone burden, prolonged surgery duration, prone position during surgery, and the use of pneumatic lithotripsy were significant variables. Conclusions. Increased stone burden, prolonged duration of surgery, prone position, and pneumatic lithotripsy during PCNL are significant risk factors for developing postoperative complications, mainly fever.