Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery

Nussmeier, Nancy A.; Whelton, Andrew; Brown, Mark T.; Langford, R. M.; Hoeft, Andreas; Parlow, Joel L.; Boyce, Steven W.; Verburg, Kenneth M.

doi:10.1056/nejmoa050330

Cited by 978 publications

(406 citation statements)

References 32 publications

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“…The majority of the studies were observational studies (n=49), 16 studies were RCTs, and 3 were meta‐analyses (Tables 1 and 2). 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84 Of the 16 RCTs identified,1...…”

Section: Resultsmentioning

confidence: 99%

Incidence of Venous Thromboembolism and Benefits and Risks of Thromboprophylaxis After Cardiac Surgery: A Systematic Review and Meta‐Analysis

Bham

Pavey

2015

JAHA

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BackgroundOptimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without complications after cardiac surgery.Methods and ResultsTwo reviewers independently searched and assessed the quality and outcomes of randomized, controlled trials (RCTs) and observational studies on VTE after cardiac surgery in the MEDLINE, EMBASE, and Cochrane controlled trial register (1966 to December 2014). Sixty‐eight studies provided data on VTE outcomes or complications related to thromboprophylaxis after cardiac surgery. The majority of the studies were observational studies (n=49), 16 studies were RCTs, and 3 were meta‐analyses. VTE prophylaxis was associated with a reduced risk of PE (relative risk [RR], 0.45; 95% confidence interval [CI], 0.28–0.72; P=0.0008) or symptomatic VTE (RR, 0.44; 95% CI, 0.28–0.71; P=0.0006) compared to the control without significant heterogeneity. Median incidence (interquartile range) of symptomatic DVT, PE, and fatal PE were 3.2% (0.6–8.1), 0.6% (0.3–2.9), and 0.3% (0.08–1.7), respectively. Previous history of VTE, obesity, left or right ventricular failure, and prolonged bed rest, mechanical ventilation, or use of a central venous catheter were common risk factors for VTE. Bleeding or cardiac tamponade requiring reoperation owing to pharmacological VTE prophylaxis alone, without systemic anticoagulation, was not observed.ConclusionsUnless proven otherwise by adequately powered RCTs, initiating pharmacological VTE prophylaxis as soon as possible after cardiac surgery for patients who have no active bleeding is highly recommended.

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Section: Resultsmentioning

confidence: 99%

Incidence of Venous Thromboembolism and Benefits and Risks of Thromboprophylaxis After Cardiac Surgery: A Systematic Review and Meta‐Analysis

Bham

Pavey

2015

JAHA

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“…6 Sales of diclofenac and ibuprofen account for more than half of the global sales of NSAIDs for osteoarthritis, and in the United States NSAID sales represent a significant fraction of the nonprescription, over-the-counter analgesic market. Side effects associated with chronic, longterm use of NSAIDs include direct and indirect irritation of the gastrointestinal tract (e.g., peptic ulcer disease, stomach bleeding, perforation, and obstruction), [7][8][9][10] increased risk of cardiovascular adverse effects (e.g., myocardial infarction and stroke, and hypertension), [11][12][13] renal failure (e.g., kidney failure), and erectile dysfunction.…”

Section: Scope Of This Volumementioning

confidence: 99%

“…Original Measurements: (1) 2′,4′-Difluoro-4-hydroxy-1, 1′-biphenyl-3-carboxylic acid (Diflunisal); C 13 …”

Section: Diflunisal Solubility Data In Aromatic Hydrocarbonsmentioning

confidence: 99%

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

Acree

2014

Journal of Physical and Chemical Reference Data

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“…4,38 Medications such as acetaminophen and nonsteroidal anti-inflammatory drugs are frequently used for the long-term management of pain associated with OA but do not specifically address OA-associated changes in movement and strength, and have potentially serious side effects. 40,[42][43][44] The increasing prevalence of knee OA and the risks associated with long-term nonsteroidal anti-inflammatory drugs T T STUDY DESIGN: Descriptive biomechanical study using an experimental repeated-measures design.…”

mentioning

confidence: 99%

Knee Extension and Stiffness in Osteoarthritic and Normal Knees: A Videofluoroscopic Analysis of the Effect of a Single Session of Manual Therapy

Taylor¹,

Wilken²,

Deyle³

et al. 2014

Journal of Orthopaedic & Sports Physical Therapy

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TherapistsTwo physical therapists (A.L.T. and N.W.G.) participated in the examination and treatment of all participants in this study. Both therapists were board certified in orthopaedic physical therapy. One therapist was a faculty member and a graduate of a long-term, in-residence, American Physical Therapy Association-accredited manual therapy fellowship, and the other provider was a fellow in training in the same program. The fellow in training and the faculty member, respectively, had 5 years and 14 years of clinical experience. ExaminationAll participants with knee OA provided age, height, weight, pain location and severity, duration of symptoms, and medication usage. They also completed a standard medical history screening and the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire. The Western Ontario and McMaster Universities Osteoarthritis Index includes pain, function, and stiffness subscales. The participants with normal knees provided age, height, weight, and medication usage and completed a standard medical history screening questionnaire. The participants with normal knees were matched to those with knee OA by age, sex, and BMI. Once demographic data were collected, knee extension angle and end-range joint stiffness of the most symptomatic lower extremity were assessed in the participants with OA. The corresponding right or left limb was assessed in the matched participant. InstrumentationPrevious studies that have attempted to quantify joint motion and stiffness in individuals with knee OA have utilized a pendulum test 7,41 previously developed to assess spasticity in patients with neurological conditions. One limitation of the pendulum test is that it measures midrange rotational stiffness, which may limit its clinical applicability to individuals with knee OA, who typically demonstrate a loss of end-range movement. 14,27,29,39 In addition, manual therapy assessment and treatment decisions are typically based on end-range motion or stiffness, as decreased terminal knee flexion or extension theoretically has the greatest impact on function. Therefore, videofluoroscopy was utilized to capture motion at the end range of extension, as it is considered by many to be the gold standard for measuring osteokinematic movement. 24,32,33 Each participant underwent 3 imaging sessions within the same day. The laboratory temperature was kept consistent for all imaging sessions and all participants. Data from the first imaging session were recorded as the baseline measurements. Manual therapy intervention was performed between imaging sessions 1 and 2 (posttreatment measurement). Immediately following imaging session 2, the participant walked around the measurement apparatus and then underwent a third imaging session to establish the reliability of the measurements.To obtain each image, the participant was placed in the supine position within the imaging apparatus, as shown in FIGURES 2 and 3. The limb to be imaged was placed on an apparatus inclined at 45° and secured to the board with...

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Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery

Abstract: The use of parecoxib and valdecoxib after CABG was associated with an increased incidence of cardiovascular events, arousing serious concern about the use of these drugs in such circumstances.

Cited by 978 publications

References 32 publications

Incidence of Venous Thromboembolism and Benefits and Risks of Thromboprophylaxis After Cardiac Surgery: A Systematic Review and Meta‐Analysis

Incidence of Venous Thromboembolism and Benefits and Risks of Thromboprophylaxis After Cardiac Surgery: A Systematic Review and Meta‐Analysis

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

Knee Extension and Stiffness in Osteoarthritic and Normal Knees: A Videofluoroscopic Analysis of the Effect of a Single Session of Manual Therapy

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