Complications of Total Hip Replacement Surgery with K. Y. M. Rotation Type Prosthesis (Modification of Weber-Huggler Type)

Halothane and isoflurane preferentially depress a slowly inactivating component of Ca2+ channel current in guinea‐pig myocytes.

“…The observed rise in kBa along with the decrease in IBa,ss during application of halothane or isoflurane argues for an increase in the transition rate from states 0 to Ii. In fact, the increase in the rate of inactivation explains the majority of the effect of isoflurane, in agreement with a recent report (Hirota, Fujimura, Wakasugi & Ito, 1996). The slight effect of isoflurane on steady-state inactivation of ICa implies an additional effect of isoflurane, perhaps to increase the transition rate from I1 to I2' There is evidence to suggest that isoflurane and to a lesser extent halothane may reduce the membrane dipole potential which would be consistent with my observations concerning steady-state inactivation (Qin, Szabo & Cafiso, 1995).…”