Complications of Viral Influenza

Rothberg, Michael B.; Haessler, Sarah; Brown, Richard B.

doi:10.1016/j.amjmed.2007.10.040

Cited by 400 publications

(368 citation statements)

References 81 publications

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“…Influenza is a respiratory disease responsible for substantial increase in morbidity, mortality and costs during seasonal epidemics and pandemics 1, 2, 3, 4, 5, 6. The World Health Organization (WHO) estimates that annually seasonal influenza epidemics result in an estimated 3‐5 million cases of severe disease and 250 000‐500 00 deaths 7.…”

Section: Introductionmentioning

confidence: 99%

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Gefenaitė

Pistol

Popescu

et al. 2017

Influenza Resp Viruses

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BackgroundInfluenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle‐income countries in the WHO European Region.ObjectivesTo estimate the incidence of medically attended influenza‐associated influenza‐like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public healthcare facilities in Romania.Patients/MethodsSentinel influenza surveillance data for ILI and SARI from 2011/12‐2015/16, including virological data, were used to estimate influenza‐associated ILI and SARI incidence/100 000 and their 95% confidence intervals (95% CI).ResultsThe overall annual incidence of ILI and influenza‐associated ILI per 100 000 persons in Romania varied between 68 (95% CI: 61‐76) and 318 (95% CI: 298‐338) and between 23 (95% CI: 19‐29) and 189 (95% CI: 149‐240), respectively. The highest ILI and influenza incidence was among children aged 0‐4 years. We estimated that SARI incidence per 100 000 persons was 6 (95% CI: 5‐7) to 9 (95% CI: 8‐10), of which 2 (95% CI: 1‐2) to 3 (95% CI: 2‐4) were due to influenza. Up to 0.3% of the Romanian population were annually reported with ILI, and 0.01% was hospitalized with SARI, of which as much as one‐third could be explained by influenza.ConclusionsThis evaluation was the first study estimating influenza burden in Romania. We found that during each influenza season, a substantial number of persons in Romania suffer from influenza‐related ILI or are hospitalized due to influenza‐associated SARI.

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Section: Introductionmentioning

confidence: 99%

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Gefenaitė

Pistol

Popescu

et al. 2017

Influenza Resp Viruses

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“…Pneumonia is recognized as the most important complication of influenza 12 . Lower respiratory infection in patients with influenza may be caused directly by viral invasion 13 or result from secondary bacterial complications 14 .…”

Section: Discussionmentioning

confidence: 99%

Clinical epidemiology comparison of H1N1 RT-PCR-positive and RT-PCR-negative pneumonia during the 2009-2010 pandemic in Mansoura University Hospitals, Egypt

Ahmed

Awadalla

Saleh

2011

Influenza and Other Respiratory Viruses

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Please cite this paper as: Ahmed et al. (2011) Clinical epidemiology comparison of H1N1 RT‐PCR‐positive and RT‐PCR‐negative pneumonia during the 2009–2010 pandemic in Mansoura University hospitals, Egypt. Influenza and Other Respiratory Viruses 5(4), 241–246 Background Worldwide, the infectivity and disease burden of the H1N1 pandemic were overestimated because of limited clinical experience concerning patient presentation and outcome of those infected with the novel H1N1 virus. Objective This study aimed to compare the epidemiologic clinical data among H1N1 RT‐PCR‐positive and RT‐PCR‐negative pneumonic patients during the 2009–2010 pandemic in Mansoura University Hospitals, Egypt. Methods A record‐based, case–control study was conducted for 43 adult patients admitted to the chest department isolation unit with community‐acquired pneumonia during the 2009–2010 H1N1 pandemic after reviewing of 198 suspected and confirmed H1N1 hospitalized cases. Of these patients, 20 cases were confirmed to be H1N1‐positive using an RT‐PCR detection technique. The remaining 23 patients were RT‐PCR‐negative. Demographic, clinical, laboratory and radiological data were collected and analyzed using spss version 11. Results A review of 198 hospital case records for revealed one main peak of H1N1 influenza during the last week of December 2009. Pneumonic patients who were H1N1‐positive were more likely to present with sore throat (P = 0·005), dyspnea (P = 0·002), and gastrointestinal (GIT) complaints (vomiting and diarrhea P = 0·02) when compared to the H1N1‐negative group. Also, complications were significantly more frequent (P = 0·01) in the H1N1‐confirmed group than in the non‐confirmed group. However, no significant differences were found between the groups regarding length of hospital stay, intensive care unit (ICU), and admission or mortality. Conclusion Sore throat, dyspnea, and presence of GIT complaints increase the suspicion of H1N1 positivity in pneumonia acquired during an H1N1 pandemic. However, H1N1 did not worsen the disease burden of pneumonia.

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“…Pulmonary complications are those most frequently encountered [1][2][3][4]. Extra-pulmonary complications are rare, but can affect numerous organ systems and include cardiac complications such as myocarditis and pericarditis [2].…”

Section: Discussionmentioning

confidence: 99%

Influenza A‐induced rhabdomyolysis and acute kidney injury complicated by posterior reversible encephalopathy syndrome

Fearnley

Lines²,

Lewington

et al. 2011

Anaesthesia

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SummaryWe report a case of Influenza A‐induced rhabdomyolysis causing acute kidney injury in a young adult female who required invasive ventilation and renal replacement therapy. This case was further complicated by posterior reversible encephalopathy syndrome. Although this represents an extremely rare neurological complication of Influenza A infection, an appreciation of the condition and its management is important, given the high numbers of critically ill patients recently affected by H1N1 Influenza A in intensive care units in the UK.

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Complications of Viral Influenza

Cited by 400 publications

References 81 publications

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Clinical epidemiology comparison of H1N1 RT-PCR-positive and RT-PCR-negative pneumonia during the 2009-2010 pandemic in Mansoura University Hospitals, Egypt

Influenza A‐induced rhabdomyolysis and acute kidney injury complicated by posterior reversible encephalopathy syndrome

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