Complications of vitamin D deficiency from the foetus to the infant: One cause, one prevention, but who's responsibility?

Högler, Wolfgang

doi:10.1016/j.beem.2015.03.003

Cited by 62 publications

(61 citation statements)

References 81 publications

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“…Женщины с дефицитом витамина D во время бере-менности имеют шанс родить ребенка с дефицитом вита-мина D и риском рахита и гипокальциемических судорог в грудном возрасте [38][39][40].…”

Section: витамин D и кальцийunclassified

Nutritional Rickets – Revisited

Плудовски¹,

Захарова²

2016

Med. sov.

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Section: витамин D и кальцийunclassified

Nutritional Rickets – Revisited

Плудовски¹,

Захарова²

2016

Med. sov.

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“…In children, rickets and osteomalacia always coexist. The most common cause of rickets and osteomalacia worldwide is calcium deprivation, secondary to low dietary calcium (‘nutritional’) and/or low ultraviolet B (UVB) sunlight exposure,1 the main source of cutaneous vitamin D production (‘solar’) 2. There is very little vitamin D in diet (including breast milk) and thus humans are mainly dependent on solar UVB for vitamin D supply.…”

Section: Introductionmentioning

confidence: 99%

Prevention of rickets and osteomalacia in the UK: political action overdue

Uday

Högler

2018

Arch Dis Child

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The consequences of vitamin D and dietary calcium deficiency have become a huge public health concern in the UK. The burden of disease from these deficiencies includes rickets, and hypocalcaemic seizures, dilated cardiomyopathy and mostly occult myopathy and osteomalacia. The increasing burden of the disease is intrinsically linked to ethnicity and the population demographic changes in the UK. Three facts have led to the resurfacing of the English disease: (1) the UK has no ultraviolet sunlight for at least 6 months of the year, (2) dark skin produces far less vitamin D than white skin per unit ultraviolet light exposure, and (3) non-European Union immigration over the last century. To date, the UK government demonstrates incomplete understanding of these three facts, and its failure to adjust its prevention programmes to changing demographics is endangering the health and life of UK residents with dark skin, of whom infants are the most vulnerable. Establishing accountability through the implementation of monitored antenatal and infantile supplementation programmes and mandatory food fortification is overdue.

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“…Since infants are generally protected from the sun and breast milk does not contain adequate levels of vitamin D, daily supplementation in doses of 400 IU per day is mandatory for the prevention of rickets 11. Babies born to vitamin D-deficient mothers are themselves vitamin D-deficient, as evidenced by the correlation in 25-hydroxyvitamin D levels between maternal and fetal metabolism 12. These infants can rapidly develop hypocalcaemia, which can lead to seizures from birth onwards followed by dilated cardiomyopathy and/or rickets 12.…”

Section: Introductionmentioning

confidence: 99%

“…Babies born to vitamin D-deficient mothers are themselves vitamin D-deficient, as evidenced by the correlation in 25-hydroxyvitamin D levels between maternal and fetal metabolism 12. These infants can rapidly develop hypocalcaemia, which can lead to seizures from birth onwards followed by dilated cardiomyopathy and/or rickets 12. These can be treated by administration of higher vitamin D doses.…”

Section: Introductionmentioning

confidence: 99%

Shelf life after opening of prescription medicines and supplements with vitamin D₃for paediatric use

Temova

Roškar

2016

Eur J Hosp Pharm

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ObjectivesThe aim of this study was to evaluate the effect of storage conditions on the shelf life of liquid pharmaceuticals with vitamin D3 in order to determine appropriate storage conditions and shelf life after the product has been opened. Manufacturers rarely specify the shelf life after products have been opened, which leads to a controversial debate among medical professionals regarding the safety of products after opening and optimal storage conditions and considerably different recommendations to the public.MethodsEffect of storage conditions on the shelf life was evaluated by comparing the isothermal stability of vitamin D3 in three prescription and three non-prescription medicines at different temperatures (4°C, 25°C and 40°C) using stability-indicating high performance liquid chromatography assay.ResultsMost of the examined preparations had a higher vitamin D3 content than the label claim when the products were first opened, presumably to compensate for loss during production and storage. An association was observed between the initial vitamin D3 content and its stability in the preparations. The vitamin D3 overage in liquid prescription medicines guaranteed its content >90% of the amount claimed on the label for at least 1 year when stored at 25°C and for 4 months at 40°C. All tested preparations are consumed when used as recommended over this period. Since some manufacturers recommend storage below room temperature, redefining the storage conditions is of practical significance.ConclusionsThe shelf life after opening examined prescription medicines containing vitamin D3 as their main active ingredient is at least 1 year at room temperature.

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Complications of vitamin D deficiency from the foetus to the infant: One cause, one prevention, but who's responsibility?

Cited by 62 publications

References 81 publications

Nutritional Rickets – Revisited

Nutritional Rickets – Revisited

Prevention of rickets and osteomalacia in the UK: political action overdue

Shelf life after opening of prescription medicines and supplements with vitamin D₃for paediatric use

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Complications of vitamin D deficiency from the foetus to the infant: One cause, one prevention, but who's responsibility?

Cited by 62 publications

References 81 publications

Nutritional Rickets – Revisited

Nutritional Rickets – Revisited

Prevention of rickets and osteomalacia in the UK: political action overdue

Shelf life after opening of prescription medicines and supplements with vitamin D3for paediatric use

Contact Info

Product

Resources

About

Shelf life after opening of prescription medicines and supplements with vitamin D₃for paediatric use