Component Analysis of Wasabi Leaves and an Evaluation of their Anti-inflammatory Activity

Abstract

The methanol extracts of wasabi leaves (Wasabia japonicaMatsumura

5‐Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3‐L1 adipocyte differentiation

“…Activity‐guided fractionation from the MeOH extract of wasabi leaves obtained from the study by Yoshida et al () was performed. Compound 1 was isolated from the EtOAc extract.…”

“…In contrast, wasabi leaves are mostly discarded because they contain little isothiocyanates. However, several studies on the components and functionalities of wasabi leaves have been conducted recently, showing that they contain flavonoids (Hosoya, Yun, & Kunugi, 2005), phenylpropanoids (Hosoya, Yun, & Kunugi, 2008), terpenoids (Yoshida, Hosoya, Inui, Masuda, & Kumazawa, 2015), and carotenoids (Yoshida et al, 2015). Meanwhile, the functional studies revealed that their effects include antioxidant (Hosoya et al, 2008) and anti-inflammatory activities (Yoshida et al, 2015).…”

“…However, several studies on the components and functionalities of wasabi leaves have been conducted recently, showing that they contain flavonoids (Hosoya, Yun, & Kunugi, 2005), phenylpropanoids (Hosoya, Yun, & Kunugi, 2008), terpenoids (Yoshida, Hosoya, Inui, Masuda, & Kumazawa, 2015), and carotenoids (Yoshida et al, 2015). Meanwhile, the functional studies revealed that their effects include antioxidant (Hosoya et al, 2008) and anti-inflammatory activities (Yoshida et al, 2015). Interestingly, 5-hydroxyferulic acid methyl ester (1: 5-HFA ester; Figure 1), one of the phenylpropanoids isolated from wasabi leaves, but not isolated from other plants, showed both of these types of activity (Hosoya et al, 2008;Yoshida et al, 2015).…”

“…Meanwhile, the functional studies revealed that their effects include antioxidant (Hosoya et al, 2008) and anti-inflammatory activities (Yoshida et al, 2015). Interestingly, 5-hydroxyferulic acid methyl ester (1: 5-HFA ester; Figure 1), one of the phenylpropanoids isolated from wasabi leaves, but not isolated from other plants, showed both of these types of activity (Hosoya et al, 2008;Yoshida et al, 2015). Studies have also revealed that wasabi leaves exert various types of anti-obesity activity.…”

A Review of Propagation Techniques and Isothiocyanates Content in Wasabi (Wasabia japonica Matsum.)

“…However, research results suggest other possible uses of this crop in plant protection and in human medicine. Wasabi has a strong antimicrobial (Depree et al, 1999;Delaquis and Mazza, 1995;Khan et al, 2006), anti-inflammatory (Yoshida et al, 2015;Uto et al, 2005) and antibacterial effect (Shin et al, 2004). Many authors recorded positive medicinal effects of Wasabi-extracted substances.…”