Component composition of Achillea salicifolia Besser essential oil  and its biological activity

Suleimen, E. M.; Zhanzhaxina, A.Sh.; Ishmuratova, Margarita

doi:10.31489/2019ch2/29-34

Cited by 3 publications

(2 citation statements)

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“…A. tenuifolia and A. magnifica oils exerted mild antifungal activity against Cryptococcus neoformans (IC 50 = 20 and 15 µg/ml, respectively) and A. tenuifolia oil displayed weak antimycobacterial activity against Mycobacterium intracellulare (IC 50 = 200 μg/ml) (109). A. micrantha EO (with the main component 1,8-cineole) did not possess antibacterial (against S. aureus, MRSA, E. coli and P. aeruginosa), anti-tuberculosis, antifungal (against C. albicans, C. glabrata, C. krusei, A. fumigatus and C. neoformans), and antimalarial activities (110).…”

Section: Essential Oilmentioning

confidence: 96%

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Salehi

Selamoğlu

Sevindik

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp. In a number of preclinical studies, Achillea plants and their essential oils have demonstrated promising antibacterial properties against a number of human and plant pathogens. Besides, the plants have displayed strong antioxidative and potent anti-proliferative and anticancer properties in various cellular and animal models. Achillea plants have widely been used as food preservative in food industry. Clinical studies have indicated its potential against multiple sclerosis (MS), irritable bowel syndrome (IBS), ulcerative colitis, episiotomy wound, primary dysmenorrhea, oral mucositis etc. The present work focuses to provide a brief overview on folk knowledge, phytochemistry, biological activity and applications of Achillea plants. There is a close relationship between the traditional ethnobotanical usage and pharmacological and clinical data from different Achillea spp. The application of Achillea plants and their extracts seems to be a promising alternative for antimicrobial and antioxidant purposes in food, pharmaceutical and cosmetic industries.

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Section: Essential Oilmentioning

confidence: 96%

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Salehi

Selamoğlu

Sevindik

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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“…[ 5 , 6 ], and Cousinia alata [ 7 , 8 ], have been previously studied. In addition, the essential oils of various plants have been investigated [ 9 , 10 ]. In continuation of this work, this study outlines the composition of Calligonum tetrapterum Jaub.…”

Section: Introductionmentioning

confidence: 99%

Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3-O-(6″-O-acetyl)-Glucoside from Calligonum tetrapterum

Suleimen

Jose

Mamytbekova

et al. 2022

Plants

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The phytochemical constituents of Calligonum tetrapterum Jaub. & Spach (Family Polygonaceae) were studied for the first time. The study resulted in the isolation of the rare flavonol glycoside, kaempferol 3-O-(6″-O-acetyl)-glucoside,(K3G-A). The potential inhibitive activity of K3G-A toward SARS-CoV-2 was investigated utilizing several in silico approaches. First, molecular fingerprints and structural similarity experiments were carried out for K3G-A against nine co-crystallized ligands of nine proteins of SARS-CoV-2 to reveal if there is a structural similarity with any of them. The conducted studies showed the high similarity of K3G-A and remdesivir, the co-crystallized ligand of SARS-CoV-2 RNA-dependent RNA polymerase (PDB ID: 7BV2), RdRp. To validate these findings, a DFT study was conducted and confirmed the proposed similarity on the electronic and orbital levels. The binding of K3G-A against RdRp was confirmed through molecular docking studies exhibiting a binding energy of −27.43 kcal/mol, which was higher than that of remdesivir. Moreover, the RdRp-K3G-A complex was subjected to several MD studies at 100 ns that authenticated the accurate mode of binding and the correct dynamic behavior. Finally, in silico ADMET and toxicity evaluation of K3G-A was conducted and denoted the safety and the drug-likeness of K3G-A. In addition to K3G-A, two other metabolites were isolated and identified to be kaempferol (K) and β-sitosterol (β-S).

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Chemical Composition and Anti-Biofilm Activity of the Essential Oil from Achillea alimeana

Semiz,

Gunal,

Dogan

2023

Chem Nat Compd

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Component composition of Achillea salicifolia Besser essential oil and its biological activity

Cited by 3 publications

References 0 publications

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Isolation and In Silico Inhibitory Potential against SARS-CoV-2 RNA Polymerase of the Rare Kaempferol 3-O-(6″-O-acetyl)-Glucoside from Calligonum tetrapterum

Chemical Composition and Anti-Biofilm Activity of the Essential Oil from Achillea alimeana

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