This paper deals with the cryogenic risk arising from nitrogen spillage in a box located in Hall A of the underground laboratories of the Gran Sasso National Laboratory, Assergi (L'Aquila). This box will be used as a storage area for some sensitive material (crystals) which will be used for an experiment called "CUORE". Starting from the Fault Tree Analysis (FTA), in order to estimate the global risk for human activities, a consequence analysis has been performed, using EFFECTS software models. The gap between the latest and the real scenario has been covered by a real test during which a "monitored, measured and controlled" gas nitrogen flow has been spilled into the box. Furthermore, a description of a reliable base for computational fluid dynamics (CFD) analysis is treated.