Component-resolved immunologic modifications, efficacy, and tolerance of latex sublingual immunotherapy in children

Luaces, Eva María Lasa; Purroy, Ana Isabel Tabar; Figueroa, Blanca Esther García; Apiñániz, Marta Anda; Laruga, Maria Luisa Sanz; Raulf‐Heimsoth, Monika; Barber, Domingo

doi:10.1016/j.anai.2012.03.005

Cited by 18 publications

(18 citation statements)

References 30 publications

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“…Lasa Luaces [ 17 ] showed both the effectiveness (increased triggering dose during the conjunctival provocation test) and immunological changes after 6 and 12 months of treatment. In his work the IgG4 appeared to increase between 6 and 12 months of therapy, while the basophil activation test with latex showed a reduction of reactivity after 6 months.…”

Section: Discussionmentioning

confidence: 99%

Latex immunotherapy: evidence of effectiveness

Nucera¹,

Mezzacappa²,

Buonomo³

et al. 2018

pdia

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IntroductionThe only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization.AimTo verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years.Material and methodsWe enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization.ResultsWe observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked.ConclusionsAlthough the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.

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Section: Discussionmentioning

confidence: 99%

Latex immunotherapy: evidence of effectiveness

Nucera¹,

Mezzacappa²,

Buonomo³

et al. 2018

pdia

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“…A recent prospective, observational, open, case-control study provided encouraging results in children [223], but was not confirmed in a randomized double-blind placebo-controlled (RDBPC) trial in adults [224]. …”

Section: Chapter 10: Methodology Of Clinical Trialsmentioning

confidence: 99%

Sublingual immunotherapy: World Allergy Organization position paper 2013 update

Canonica

Cox

Pawankar

et al. 2014

World Allergy Organization Journal

452

421

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We have prepared this document, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update”, according to the evidence-based criteria, revising and updating chapters of the originally published paper, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2009”, available at http://www.waojournal.org. Namely, these comprise: “Mechanisms of sublingual immunotherapy;” “Clinical efficacy of sublingual immunotherapy” – reporting all the data of all controlled trials published after 2009; “Safety of sublingual immunotherapy” – with the recently published Grading System for adverse reactions; “Impact of sublingual immunotherapy on the natural history of respiratory allergy” – with the relevant evidences published since 2009; “Efficacy of SLIT in children” – with detailed analysis of all the studies; “Definition of SLIT patient selection” – reporting the criteria for eligibility to sublingual immunotherapy; “The future of immunotherapy in the community care setting”; “Methodology of clinical trials according to the current scientific and regulatory standards”; and “Guideline development: from evidence-based medicine to patients' views” – including the evolution of the methods to make clinical recommendations.Additionally, we have added new chapters to cover a few emerging crucial topics: “Practical aspects of schedules and dosages and counseling for adherence” – which is crucial in clinical practice for all treatments; “Perspectives and new approaches” – including recombinant allergens, adjuvants, modified allergens, and the concept of validity of the single products. Furthermore, “Raising public awareness about sublingual immunotherapy”, as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail.

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“…In patients with pollen allergy, Van Overtvelt et al did not find a significant decrease in the BAT to various grass allergens after 2 or 4 months of SLIT [68]. In looking at SLIT for natural rubber latex allergy, the BAT to Hev b 6.01 and Hev b 6.02 decreased at 6 months but then returned to pre-treatment levels after 1 year of therapy [69]. Finally, in a Phase I study of timothy grass and dust mite dual-SLIT for pollen allergy, it was demonstrated that the BAT to those two allergens decreased after 24 months of SLIT compared to baseline values [70].…”

Section: Update On the Application Of Basophil Activation Testsmentioning

confidence: 99%

Update on the Performance and Application of Basophil Activation Tests

McGowan

Saini

2012

Curr Allergy Asthma Rep

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The basophil activation test (BAT) is a flow-cytometry-based functional assay that assesses the degree of cell activation after exposure to a stimuli. Though no standardized technique currently exists, recent advances have improved the performance of this assay, including identification of new basophil-specific markers and comparisons of the expression of CD63 to CD203c during activation. The basophil activation test has also been validated for many IgE-mediated disease conditions, which have been extensively reviewed elsewhere. This review focuses on the most recent applications of this test to the diagnosis of allergy to drugs, foods, venoms, and pollens, and the evolving role of the BAT in monitoring immunotherapy.

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Component-resolved immunologic modifications, efficacy, and tolerance of latex sublingual immunotherapy in children

Cited by 18 publications

References 30 publications

Latex immunotherapy: evidence of effectiveness

Latex immunotherapy: evidence of effectiveness

Sublingual immunotherapy: World Allergy Organization position paper 2013 update

Update on the Performance and Application of Basophil Activation Tests

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