Components of Human Split Ejaculates

Abstract

Summary. The concentrations of spermatozoa, fructose, IgG, IgA, albumin, lactoferrin, transferrin, secretory piece of IgA, \ g=b\ 1C/ \ g=b\ 1A\ x=r eq-\ globulin (C\m='\3-component of complement), ceruloplasmin and fibrinogen were evaluated in human split ejaculates and/or in whole human seminal plasma. The concentrations of spermatozoa, IgG, IgA, albumin and transferrin decreased from the first portion of the split ejaculate to the last, indicating that these proteins originate mostly from secretions other than the seminal vesicles. By contrast, the highest amounts of fructose and lactoferrin were present in the final portion of the split ejaculates, showing their seminal vesicle origin. No secretory piece, IgM, \ g=b\ 1C/ \ g=b\ 1A\ x=r eq-\ globulin, ceruloplasmin or fibrinogen could be detected in human semen. An unidentified antigen was found that has a relatively high molecular weight and shows \g=b\1-mobility on immunoelectrophoresis.

Identification of human semen insulin-like growth factor-I/somatomedin-C immunoreactivity and binding protein

“…Table 1 shows that the IGF-I/SM-C content in samples from vasectomized or azoospermic pa¬ tients (2 subjects in each category) was approxi¬ mately 60% lower than that in subjects with normal sperm densities. In split ejaculates from 2 normal subjects, the early (predominantly testicular) frac¬ tion (Tauber et al 1975) contained approximately 60% of the total activity. These observations sug¬ gest that 60% of the IGF-I/SM-C in SP is of testicular origin.…”

A patient with seminal vesiculitis prior to acute chlamydial epididymitis

“…The seminal vesicle has an important role in sperm function. 6,7 If inflammation of the seminal vesicles can be caused by C. trachomatis, this suggests that chlamydial seminal vesiculitis may be one of the causes of male infertility.…”

Immunocontraceptives: New Approaches to Fertility Control

“…Naz et al [129] found that systemic intraperitoneal injection of MA-24 ascites fluid in mouse models reduced the percentage of fertilized ova (from 69% in untreated to 29% in treated), thereby reducing the fertility in vivo [130]. For determining the in vivo contraceptive efficacy of MARS, the antibodies were incubated in vitro with a defined volume of semen, followed by insemination of females.…”