Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected

Shiau, Stephanie; Yu, Wendy; Jacobson, Denise L.; Nichols, Sharon L.; McFarland, Elizabeth J.; Chen, Janet S.; Dirajlal-Fargo, Sahera; Surowiec, Karen; Geffner, Mitchell E.; Jao, Jennifer

doi:10.1007/s13365-021-01005-8

Cited by 3 publications

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with previous findings in HIV-infected children [39,45] and adults [46]. This is concerning as there are reports associating neurocognitive deficits with two or more MetS components in CALWH [29]. Limited studies from sub-Saharan Africa have reported a much lower prevalence of HDL (6-17%) and triglyceride (6-9%), but these studies were in prepubertal children living with HIV [17,47,48].…”

Section: Prevalence Of Mets Components and Full Diagnostic Criteria F...supporting

confidence: 91%

“…Furthermore, it is unclear whether MetS in children increases the lifetime risk of cardiovascular diseases as in adults [27, 28]. Moreover, in a recent study in the US, components of MetS in CALWH was associated with lower neurocognitive performance [29]. There is an urgent need to find out the true prevalence of MetS in CALWH in sub‐Saharan Africa, home to over 90% of children and adolescents living with HIV, because the effects of MetS in this population may be more devastating than in adults due to the long and cumulative exposure to ART.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?

Kisitu,

Shabanova,

Naiga

et al. 2023

HIV Medicine

View full text Add to dashboard Cite

BackgroundAntiretroviral therapy‐associated adverse effects and comorbidities are still pervasive in people living with HIV, especially metabolic syndrome (MetS). We investigated the age‐dependent prevalence of components of MetS and insulin resistance in children and adolescents living with HIV (CALWH).MethodsA cross‐sectional pilot study of CALWH treated at the Baylor Uganda Clinical Centre of Excellence in Kampala, Uganda, May to August 2021. The primary outcome of MetS was defined by both the International Diabetes Federation (IDF) and the Adult Treatment Panel (ATP III) criteria. We estimated the prevalence of MetS and its components for all participants and by the stratification factors.ResultsWe enrolled 90 children and adolescents, aged 6 to <10 years (n = 30), 10 to <16 years (n = 30), and ≥ 16 to <19 years (n = 30). Fifty‐one percent were females. The estimated prevalence of MetS was 1.11% (1 of 90) using either IDF or ATPIII criteria for all participants, and 3.33% in the oldest age group. Notably, while only one among study participants met the criterion based on having central obesity or blood pressure, over 55% of participants had one or more IDF component, with 47% having low high‐density lipoprotein (HDL) cholesterol. Two participants (6.67%) in the group aged 10 to <16 years met one of the definitions for insulin resistance (IR) using the Homeostatic Model Assessment (HOMA‐IR) index. For every 1‐year increase in age, HOMA‐IR index increased by 0.04 (95% confidence interval: 0.01–0.08; p = 0.02).ConclusionsWith increasing survival of CALWH into adulthood, lifetime exposure to ART, the frequency of MetS in this population may rise, increasing the lifetime risk for associated health problems. There is a need to study the natural history of MetS in CALWH to inform preventative and treatment interventions as needed.

show abstract

Section: Prevalence Of Mets Components and Full Diagnostic Criteria F...supporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?

Kisitu,

Shabanova,

Naiga

et al. 2023

HIV Medicine

View full text Add to dashboard Cite

show abstract

“…All of these are attributable to HIV itself, inflammation, and side effects of antiretroviral therapy [79] . AIDS-related inflammation and immune activation also occur throughout the infection and treatment process, which is related to the persistence of HIV, translocation of intestinal flora, reduction of regulatory T cells, and combination or secondary infection with other viruses [80] , [81] . People who were born with HIV or acquired HIV in early childhood were found to be significantly more likely to develop metabolic abnormalities, including insulin resistance, high triglyceride levels, and adverse weight gain [82] .…”

Section: Roles Of Il-6-mediated Immunometabolic Reprogramming In Vira...mentioning

confidence: 99%

Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases

Ren

Cao

2022

International Immunopharmacology

View full text Add to dashboard Cite

Cognitive impairment in children and adolescents living with perinatal HIV disease in the ART era: a meta-analysis

Dahmani,

Rakhmanina,

Jiang

2024

eClinicalMedicine

View full text Add to dashboard Cite

Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected

Cited by 3 publications

References 67 publications

High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?

High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?

Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases

Cognitive impairment in children and adolescents living with perinatal HIV disease in the ART era: a meta-analysis

Contact Info

Product

Resources

About