Components of the metabolic syndrome (MTS), hyperinsulinemia, and insulin resistance in obese Israeli children and adolescents

Mapping liver fat female-dependent quantitative trait loci in collaborative cross mice

“…In developed countries such as the United States, NAFLD has become the most common cause of chronic liver disease. The rate of NAFLD is increasing likely due to the rising prevalence of associated conditions in adults as well as children such as obesity and T2D, which together with dyslipidemia are the most important risk factors for NAFLD (Caldwell et al 1999;Vardi et al 2007). It has been projected that, within the next two decades, NASH will become the predominant cause of cirrhosis requiring orthotopic liver transplantation (Charlton 2004;Charlton et al 2011).…”

Association of resistin level with acanthosis nigricans in obese adolescents

“…17 Similarly, previous studies revealed a significant higher levels of resistin in obesity compared to non obesity. 18,19 Another study obtained a different result that there is no significant difference in resistin Table 5. The P-value for the average resistin levels between the two groups of acanthosis nigricans scale levels between obese and non-obese children.…”

IL-18, Adiponectin and Metabolic Parameters in Obese Adolescents

“…Adiponectin is an adipocytokine that is protective against insulin resistance and is antiatherogenic (Li et al, 2017). Insulin resistance is a predictor of metabolic syndrome in adolescent obesity (Vardi et al, 2007) 1), which is lower than previous studies on obese subjects (Tamang et al, 2013). Previous studies suggested that adiponectin levels are a protective factor against inflammation by blocking IL-18 cell death mediated via AMPK (Chandrasekar et al, 2008).…”