Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis

Abdulkina, Liliia R.; Kobayashi, Callie; Lovell, John T.; Chastukhina, Inna B.; Aklilu, Behailu Birhanu; Agabekian, Inna A; Suescún, Ana Victoria; Valeeva, Lia R.; Chuluuntsetseg, Nyamsuren; Aglyamova, Galina V.; Шарипова, М. Р.; Shippen, Dorothy E.; Juenger, Thomas E.; Shakirov, Eugene V.

doi:10.1038/s41467-019-13448-z

Cited by 21 publications

(34 citation statements)

References 47 publications

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“…Ku mutants represent the only stable, long-telomere mutants 79 described for Arabidopsis Col-0 background that do not have major genome abnormalities 21,22 . All 80 selected single-copy homozygous T-DNA mutant lines with no background contamination were 81 previously generated in the same reference Col-0 background and well-characterized 10,24,26,27 . 82…”

Section: Methodsmentioning

confidence: 99%

“…Average telomere length also differs considerably between genotypes of the same species [6][7][8][9] . Hence, telomere length is a quantitative trait, controlled by many genes [10][11][12][13] and possibly influenced by the environment. Intra-species variation in telomere length is consistent with ongoing evolution, but the degree to which this evolution is neutral or adaptive is unknown.…”

Section: Introduction 14mentioning

confidence: 99%

“…Mutations in two other genes cause telomeres to reach a shorter than in wild type, but stable set point length. One is NOP2A, a putative ribosomal RNA maturation and ribosome assembly factor, which was recently identified through QTL mapping as a positive regulator of telomere length 10 . A second gene, TAD3, encodes a tRNA adenosine 55 deaminase and promotes telomerase-independent telomere length maintenance 24 .…”

Section: Introduction 14mentioning

confidence: 99%

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Plasticity, Pleiotropy and Fitness Tradeoffs in Arabidopsis Genotypes with Different Telomere Lengths

Campitelli

Razzaque

Barbero

et al. 2021

Preprint

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Telomere length has been implicated in the organismal response to stress, but the underlying mechanisms are unknown. Here we examine the impact of telomere length changes on Arabidopsis thaliana responses to three contrasting abiotic environments, and measure 31 fitness, development, physiology and leaf-level anatomy traits. We report that telomere length in wild type and short telomere mutants is resistant to abiotic stress, while elongated telomeres in ku70 mutants are more plastic. We also detect significant pleiotropic effects of telomere length on flowering time and key leaf physiology and anatomical traits. Furthermore, our data reveal a significant genotype by environment (GxE) interaction for reproductive fitness, with the benefits and costs to performance depending on the growth conditions. These results imply that life-history tradeoffs between flowering time and reproductive fitness are impacted by telomere length variation. We postulate that telomere length in plants is subject to natural selection imposed by different environments.

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Section: Methodsmentioning

confidence: 99%

Section: Introduction 14mentioning

confidence: 99%

Section: Introduction 14mentioning

confidence: 99%

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Plasticity, Pleiotropy and Fitness Tradeoffs in Arabidopsis Genotypes with Different Telomere Lengths

Campitelli

Razzaque

Barbero

et al. 2021

Preprint

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“…The functions of these two paralogous genes may be identical because the phenotypes of rpl5a and rpl5b are similar (Fujikura et al, 2009). Interestingly, RPL5A and RPL5B have been reported to interact with NOP2A (a ribosomal RNA methyltransferase with major roles in cellular proliferation); all of these three factors play a role in the positive regulation of the telomere length set point (Abdulkina et al, 2019), which may represent an extraribosomal function of RPL5.…”

Section: Rpl5 Serves As a Novel Positive Trans-regulator Of The Telomere Length Set Pointmentioning

confidence: 99%

Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants

Xiong

Lan²,

Mo³

2021

Front. Plant Sci.

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Ribosomes are basic translational machines in all living cells. The plant cytosolic ribosome is composed of four rRNAs and approximately 81 ribosomal proteins (RPs). In addition to the fundamental functions of RPs in the messenger RNA decoding process as well as in polypeptide synthesis and ribosome assembly, extraribosomal functions of RPs that occur in the absence of the ribosome have been proposed and studied with respect to RPs’ ability to interact with RNAs and non-ribosomal proteins. In a few cases, extraribosomal functions of several RPs have been demonstrated with solid evidences in plants, including microRNA biogenesis, anti-virus defenses, and plant immunity, which have fascinated biologists. We believe that the widespread duplication of RP genes in plants may increase the potential of extraribosomal functions of RPs and more extraribosomal functions of plant RPs will be discovered in the future. In this article we review the current knowledge concerning the extraribosomal functions of RPs in plants and described the prospects for future research in this fascinating area.

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“…Their mis-expression has been detailed in numerous aberrant cellular processes. In recent years, RPs have been shown to participate in stress responses, nucleolar integrity, cell cycle control, cell proliferation, genome integrity, telomere length and cell death (Abdulkina et al, 2019; Lai et al, 2009; Moin et al, 2016; Nicolas et al, 2016). Thus, ribosome biogenesis is highly dose-dependent, with small changes impacting numerous cellular processes.…”

Section: Introductionmentioning

confidence: 99%

Cross-species Transcriptomic Network Analysis Reveals Links Between Ribosomal Protein Mutation and Cancer

Denton

Velasque

Reed

2020

Preprint

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Ribosomal proteins (RPs) are critical to all cellular operations through their key roles in ribosome biogenesis and translation, as well as their extra-ribosomal functions. Although highly tissue- and time-specific in expression, little is known about the macro-level roles of RPs in shaping transcriptomes. A wealth of RP mutants exist, including the Drosophila melanogaster Minutes, with RP encoding genes that vary from greatly under-expressed to greatly over-expressed. Leveraging a subset of these mutants and using whole-body RNA sequencing, we identified the RP macro transcriptome and then sought to compare it with transcriptomes of pathologies associated with failures of ribosomal function. Gene-based analysis revealed highly variable transcriptomes of RP mutations with little overlap in genes that were differentially expressed. In contrast, weighted gene co-expression network analysis (WGCNA) revealed a highly conserved pattern across all RP mutants studied. When we compared network changes in RP mutants, we observed similarities to transcriptome alterations in human cancer, and thus confirming the oncogenic role of RPs. Therefore, what may appear stochastic at the individual gene level, forms clearly predictable patterns when viewed as a whole.

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Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis

Cited by 21 publications

References 47 publications

Plasticity, Pleiotropy and Fitness Tradeoffs in Arabidopsis Genotypes with Different Telomere Lengths

Plasticity, Pleiotropy and Fitness Tradeoffs in Arabidopsis Genotypes with Different Telomere Lengths

Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants

Cross-species Transcriptomic Network Analysis Reveals Links Between Ribosomal Protein Mutation and Cancer

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