Composite alginate microspheres as the next-generation egg-box carriers for biomacromolecules delivery

Abstract

Composite alginate microsphere systems are the ideal carriers for controlled delivery applications because of their ability to encapsulate a myriad of therapeutic drugs, proteins, enzymes, DNA, antisense oligonucleotides, vaccines, growth factors and chemokines as well as the ease of processing, mechanical properties, biocompatibility, high bioavailability, controlled release rates, stability, suitability for different administration modes, targeted/localized delivery of different agents and large-scale production with cost-effectiveness. This article presents updated information of applying microalginate-based technologies and tools in the biomedical field which will benefit research scientists and clinical physicians or biopharmaceutical industries keen in the development of application-based new therapeutic and diagnostic strategies for various diseases. Furthermore, this technology will play more important roles in biosensors, vaccination, tissue engineering, cancer chemotherapeutics and stem cell research.

Osteogenic/Angiogenic Dual Growth Factor Delivery Microcapsules for Regeneration of Vascularized Bone Tissue

“…The synthesized PLGA NPs were then encapsulated into alginate MCs to carry out sustained delivery of dual GFs. Alginate was chosen due to its versatile use as a delivery carrier material for multiple factors (e.g., cells and proteins), and for its simple cross‐linking mechanism via divalent cation solutions. An electrodropping technique was employed to fabricate dual GF‐loaded MCs: BMP‐2‐loaded PLGA NPs and VEGF‐encapsulated alginate (Figure D).…”

“…There are many candidates in fabricating drug delivery systems, including synthetic polymers, biopolymers, and inorganic compounds. Among them, we choose alginate and poly(lactic‐ co ‐glycolic acid) (PLGA) for their proven efficacy and versatile advantages . Alginate is very useful and easy to handle for encapsulation of bioactive molecules, cells, or micro/nanoparticles.…”

Mass Production of Cell‐Laden Calcium Alginate Particles with Centrifugal Force

“…Alginate hydrogel particles are one of the most widely used natural biopolymer constructs in various applications such as cell therapy and cell cultivation because of the biocompatibility, biodegradability, and porosity of such particles . These applications require reproducible methods of obtaining monodisperse alginate hydrogel particles because variation in their sizes and shapes influence their functions.…”

Efficiently engineered cell sheet using a complex of polyethylenimine–alginate nanocomposites plus bone morphogenetic protein 2 gene to promote new bone formation

“…28 Alginate is an anionic polysaccharide with good biosafety and biodegradability and has been widely used in gene and drug delivery. 29,30 In this study, PEI-al nanocomposites were synthesized by electrostatic interaction between cationic polymer PEI and anionic polymer alginate, and blending polyanionic alginate with PEI successfully shielded the excess positive charge on PEI and then reduced its toxicity ( Figure 3B). Furthermore, this method of synthesizing PEI-al nanocomposites is very simple and easy to carry out.…”