Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized
Cellulose Nanocrystals

Stepanova, Maria; Averianov, Ilia; Solomakha, Olga; Заболотных, Н. В.; Gofman, I. V.; Сердобинцев, М. С.; Vinogradova, Tatiana; Korzhikov-Vlakh, Viktor; Korzhikova-Vlakh, Evgenia

doi:10.32604/jrm.2020.09206

Cited by 12 publications

(19 citation statements)

References 14 publications

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“…Increasing the filler content from 5 to 15 wt% resulted in a twofold increase in Young’s modulus, but at the same time a threefold decrease in tensile strength. A similar tendency was also observed for the composite films fabricated by solution casting when CNC was grafted with poly(glutamic acid) and used as a filler to PCL and PLA [ 230 , 231 ]. The effect on changes in composite morphology and material homogeneity depending on the used filler is demonstrated in Figure 17 .…”

Section: Aliphatic Polyesters/cellulose Compositessupporting

confidence: 61%

“…Being biocompatible and hydrophilic, cellulose is widely considered not only for production of degradable packaging [ 261 ] and technical materials [ 158 , 245 , 262 ], but also for the development of biomedical materials [ 263 ]. The biocompatibility of cellulose materials in vivo and in vitro is supported by several studies [ 230 , 231 , 249 ]. For example, Codreanu et al evaluated the viability and cell-proliferation potential for the composites prepared by melt mixing of PHB with bacterial cellulose using the mouse preadipocyte (3T3-L1) cell line [ 249 ].…”

Section: Aliphatic Polyesters/cellulose Compositesmentioning

confidence: 94%

“…The evaluation of cell viability on the surface of PLLA, PDLLA, or PCL composite films produced by solution casting and containing 5, 10, or 15 wt% of neat CNC or CNC modified with poly(glutamic acid) revealed the similar viability of rabbit mesenchymal stem cells after 24 h [ 230 , 231 ]. The biocompatibility of the composites was assessed after a 1-month in vivo subcutaneous biocompatibility test in rats.…”

Section: Aliphatic Polyesters/cellulose Compositesmentioning

confidence: 99%

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Modification of Cellulose Micro- and Nanomaterials to Improve Properties of Aliphatic Polyesters/Cellulose Composites: A Review

Stepanova

Korzhikova-Vlakh

2022

Polymers

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Aliphatic polyesters/cellulose composites have attracted a lot attention due to the perspectives of their application in biomedicine and the production of disposable materials, food packaging, etc. Both aliphatic polyesters and cellulose are biocompatible and biodegradable polymers, which makes them highly promising for the production of “green” composite materials. However, the main challenge in obtaining composites with favorable properties is the poor compatibility of these polymers. Unlike cellulose, which is very hydrophilic, aliphatic polyesters exhibit strong hydrophobic properties. In recent times, the modification of cellulose micro- and nanomaterials is widely considered as a tool to enhance interfacial biocompatibility with aliphatic polyesters and, consequently, improve the properties of composites. This review summarizes the main types and properties of cellulose micro- and nanomaterials as well as aliphatic polyesters used to produce composites with cellulose. In addition, the methods for noncovalent and covalent modification of cellulose materials with small molecules, polymers and nanoparticles have been comprehensively overviewed and discussed. Composite fabrication techniques, as well as the effect of cellulose modification on the mechanical and thermal properties, rate of degradation, and biological compatibility have been also analyzed.

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Section: Aliphatic Polyesters/cellulose Compositessupporting

confidence: 61%

Section: Aliphatic Polyesters/cellulose Compositesmentioning

confidence: 94%

Section: Aliphatic Polyesters/cellulose Compositesmentioning

confidence: 99%

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Modification of Cellulose Micro- and Nanomaterials to Improve Properties of Aliphatic Polyesters/Cellulose Composites: A Review

Stepanova

Korzhikova-Vlakh

2022

Polymers

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“…This is in contrast to lamellar GO and rGO platelets, having smoothed surface with a low extent of wrinkling and folding. The corrugation of rGO-Am is an intrinsic characteristic of this material related to both the distortion of the graphene layer at nanoscale due to introduced amines and the interaction of amines with the retained oxygenic groups, resulting in folding at a microscale [ 34 ]. Notably, it does not depend on the type of solvent used for the deposition varied from the polar ones (isopropyl alcohol) to nonpolar solvents (trichloromethane and tetrachloromethane).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, we have successfully applied this approach to improve the compatibility of the hydrophobic PLA and PCL with hydrophilic filler (nanocrystalline cellulose) by its grafting with amphiphilic polypeptide [ 32 ]. Such modification allowed the enhancement of the composite mechanical characteristics and also favored the matrix mineralization [ 12 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Aminated Graphene-Graft-Oligo(Glutamic Acid) /Poly(ε-Caprolactone) Composites: Preparation, Characterization and Biological Evaluation

et al. 2021

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Biodegradable and biocompatible composites are of great interest as biomedical materials for various regeneration processes such as the regeneration of bones, cartilage and soft tissues. Modification of the filler surface can improve its compatibility with the polymer matrix, and, as a result, the characteristics and properties of composite materials. This work is devoted to the synthesis and modification of aminated graphene with oligomers of glutamic acid and their use for the preparation of composite materials based on poly(ε-caprolactone). Ring-opening polymerization of N-carboxyanhydride of glutamic acid γ-benzyl ester was used to graft oligomers of glutamic acid from the surface of aminated graphene. The success of the modification was confirmed by Fourier-transform infrared and X-ray photoelectron spectroscopy as well as thermogravimetric analysis. In addition, the dispersions of neat and modified aminated graphene were analyzed by dynamic and electrophoretic light scattering to monitor changes in the characteristics due to modification. The poly(ε-caprolactone) films filled with neat and modified aminated graphene were manufactured and carefully characterized for their mechanical and biological properties. Grafting of glutamic acid oligomers from the surface of aminated graphene improved the distribution of the filler in the polymer matrix that, in turn, positively affected the mechanical properties of composite materials in comparison to ones containing the unmodified filler. Moreover, the modification improved the biocompatibility of the filler with human MG-63 osteoblast-like cells.

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3D‐Printed composite scaffolds based on poly(ε‐caprolactone) filled with poly(glutamic acid)‐modified cellulose nanocrystals for improved bone tissue regeneration

et al. 2022

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The manufacturing of modern scaffolds with customized geometry and personalization has become possible due to the three‐dimensional (3D) printing technique. A novel type of 3D‐printed scaffolds for bone tissue regeneration based on poly(ε‐caprolactone) (PCL) filled with nanocrystalline cellulose modified by poly(glutamic acid) (PGlu‐NCC) has been proposed in this study. The 3D printing set‐ups were optimized in order to obtain homogeneous porous scaffolds. Both polymer composites and manufactured 3D scaffolds have demonstrated mechanical properties suitable for a human trabecular bone. Compression moduli were in the range of 334–396 MPa for non‐porous PCL and PCL‐based composites, and 101–122 MPa for porous scaffolds made of the same materials. In vitro mineralization study with the use of human mesenchymal stem cells (hMSCs) revealed the larger Ca deposits on the surface of PCL/PGlu‐NCC composite scaffolds. Implantation of the developed 3D scaffolds into femur of the rabbits was carried out to observe close and delayed effects. The histological analysis showed the lowest content of immune cells and thin fibrous capsule, revealing low toxicity of the PCL/PGlu‐NCC scaffolds seeded with rabbit MSCs (rMSCs) to the surrounding tissues. The most pronounced result on the generation of new bone tissue after implantation of PCL/PGlu‐NCC + rMSCs scaffolds was detected by both microcomputed tomography and histological analysis. Around 33% and 55% of bone coverage were detected for composite 3D scaffolds with adhered rMSCs after 1 and 3 months of implantation, respectively. This achievement can be a result of synergistic effect of PGlu, which attracts calcium ions, and stem cells with osteogenic potential.

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Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals

Cited by 12 publications

References 14 publications

Modification of Cellulose Micro- and Nanomaterials to Improve Properties of Aliphatic Polyesters/Cellulose Composites: A Review

Modification of Cellulose Micro- and Nanomaterials to Improve Properties of Aliphatic Polyesters/Cellulose Composites: A Review

Aminated Graphene-Graft-Oligo(Glutamic Acid) /Poly(ε-Caprolactone) Composites: Preparation, Characterization and Biological Evaluation

3D‐Printed composite scaffolds based on poly(ε‐caprolactone) filled with poly(glutamic acid)‐modified cellulose nanocrystals for improved bone tissue regeneration

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