Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic: Leaching, bioactivity and cytocompatibility

Verné, Enrica; Bruno, Matteo; Miola, Marta; Maina, Giovanni; Bianco, Carlotta; Cochis, Andrea; Rimondini, Lia

doi:10.1016/j.msec.2015.03.039

Cited by 47 publications

(23 citation statements)

References 31 publications

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“…This bioactivity test is widely adopted in vitro to assess whether the biomaterial is favorable for bone bonding and formation in vivo , since it has been reported that in vitro hydroxyapatite formation can be correlated to in vivo bioactivity of a biomaterial [40–42]. It has been reported that PCL scaffold is difficult to form hydroxyapatite probably due to the bio-inertness and slow degradation nature [8].…”

Section: Discussionmentioning

confidence: 99%

Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

et al. 2017

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Nanofibrous scaffolds that are morphologically/structurally similar to natural ECM are highly interested for tissue engineering; however, the electrospinning technique has the difficulty in directly producing clinically relevant 3D nanofibrous scaffolds with desired structural properties. To address this challenge, we have developed an innovative technique of thermally induced nanofiber self-agglomeration (TISA) recently. The aim of this work was to prepare (via the TISA technique) and evaluate 3D electrospun PCL/PLA blend (mass ratio: 4/1) nanofibrous scaffolds having high porosity of ~95.8% as well as interconnected and hierarchically structured pores with sizes from sub-micrometers to ~300 µm for bone tissue engineering. The hypothesis was that the incorporation of PLA (with higher mechanical stiffness/modulus and bioactivity) into PCL nanofibers would significantly improve human mesenchymal stem cells (hMSCs) osteogenic differentiation in vitro and bone formation in vivo. Compared to neat PCL-3D scaffolds, PCL/PLA-3D blend scaffolds had higher mechanical properties and in vitro bioactivity; as a result, they not only enhanced the cell viability of hMSCs but also promoted the osteogenic differentiation. Furthermore, our in vivo studies revealed that PCL/PLA-3D scaffolds considerably facilitated new bone formation in a critical-sized cranial bone defect mouse model. In summary, both in vitro and in vivo results indicated that novel 3D electrospun PCL/PLA blend nanofibrous scaffolds would be strongly favorable/desired for hMSCs osteogenic differentiation and cranial bone formation.

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Section: Discussionmentioning

confidence: 99%

Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

et al. 2017

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“…In this regard, a composite bone cement obtained by incorporation of ferrimagnetic and bioactive glass-ceramic micro-particles in the PMMA polymeric matrix in different amounts has been proposed ( Bretcanu et al, 2006 ). This material is able to generate heat under an external alternating magnetic field sustaining also osteoblast viability and interaction with the biomaterial itself ( Verné et al, 2015 ).…”

Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

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“…Once in the tumor, these materials generate heat within the diseased tissue area, leading to the destruction of tumor cells at temperatures of 42‐46°C, while normal cells can survive at these temperatures . The heating capacity of the thermoseed materials is the key factor for the success of the hyperthermia process, while bioactivity is another important requirement for the thermoseed materials …”

Section: Introductionmentioning

confidence: 99%

“…2 The heating capacity of the thermoseed materials is the key factor for the success of the hyperthermia process, 3 while bioactivity is another important requirement for the thermoseed materials. 4,5 Several types of thermoseed materials have been developed in recent years including iron oxide nanoparticles, ferromagnetic alloys and ferromagnetic glass-ceramics. 6 Although iron oxide nanoparticles have been used in humans in magnetic resonance imaging and tested for antitumor hyperthermia therapy, 7,8 their long-term effects in the human body need further evaluation, which limits their application in magnetic induction hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

P₂O₅‐Fe₂O₃‐CaO‐SiO₂ ferromagnetic glass‐ceramics for hyperthermia

Wang

Zhang

et al. 2018

Int J Applied Ceramic Tech

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Ferromagnetic glass‐ceramics are an important kind of thermoseed material for hyperthermia treatments. In order to investigate the applications of glass‐ceramics in magnetic hyperthermia, P2O5‐Fe2O3‐CaO‐SiO2 (PFCS) glass‐ceramics with different compositions were prepared by the sol‐gel method. The crystal phase, magnetic properties, induction heating ability, and cytotoxicity of the as‐prepared glass‐ceramics were investigated. The results show that all the samples exhibit low cytotoxicity and good induction heating ability. Moreover, it was found that the phosphorus content affected the crystal phase component of the sample, and thus influenced the induction heating ability. Results of the magnetic hyperthermia experiments showed that the PFCS glass‐ceramic samples induced significant cell death of the LoVo cancer cells. The highest cell death rate for sample B2P7 was more than 95%, which suggests good application prospects in the field of hyperthermia therapy.

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Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic: Leaching, bioactivity and cytocompatibility

Cited by 47 publications

References 31 publications

Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

P₂O₅‐Fe₂O₃‐CaO‐SiO₂ ferromagnetic glass‐ceramics for hyperthermia

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Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic: Leaching, bioactivity and cytocompatibility

Cited by 47 publications

References 31 publications

Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

P2O5‐Fe2O3‐CaO‐SiO2 ferromagnetic glass‐ceramics for hyperthermia

Contact Info

Product

Resources

About

P₂O₅‐Fe₂O₃‐CaO‐SiO₂ ferromagnetic glass‐ceramics for hyperthermia