Composite Coatings for Osteoblast Growth Attachment Fabricated by Matrix-Assisted Pulsed Laser Evaporation

Grumezescu, Valentina; Ficai, Anton; Neguț, Irina; Vasile, Bogdan Ștefan; Gălățeanu, Bianca; Hudiţă, Ariana

doi:10.3390/polym14142934

Cited by 4 publications

(2 citation statements)

References 73 publications

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“…The hydroxyapatite (HA) nanoparticles were prepared by the co-precipitation method, according to our previously published papers [ 40 ]. Briefly, a P-containing and a Ca-containing solution were mixed under magnetic stirring.…”

Section: Methodsmentioning

confidence: 99%

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Grumezescu,

Gherasim,

Gălățeanu

et al. 2024

Pharmaceutics

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The bioactive surface modification of implantable devices paves the way towards the personalized healthcare practice by providing a versatile and tunable approach that increase the patient outcome, facilitate the medical procedure, and reduce the indirect or secondary effects. The purpose of our study was to assess the performance of composite coatings based on biopolymeric spheres of poly(lactide-co-glycolide) embedded with hydroxyapatite (HA) and methotrexate (MTX). Bio-simulated tests performed for up to one week evidenced the gradual release of the antitumor drug and the biomineralization potential of PLGA/HA-MTX sphere coatings. The composite materials proved superior biocompatibility and promoted enhanced cell adhesion and proliferation with respect to human preosteoblast and osteosarcoma cell lines when compared to pristine titanium.

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Section: Methodsmentioning

confidence: 99%

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Grumezescu,

Gherasim,

Gălățeanu

et al. 2024

Pharmaceutics

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“…Specific to this technique, the organic material is dissolved in a volatile solvent before being frozen at N 2 temperature. The photochemical degradation of the organic substance can be decelerated or even stopped by hitting the frozen target with a pulsed laser beam whose energy is absorbed by the solvent and turned into thermal energy [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium Phosphates–Chitosan Composite Layers Obtained by Combining Radio-Frequency Magnetron Sputtering and Matrix-Assisted Pulsed Laser Evaporation Techniques

et al. 2022

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In this work, we report the synthesis of calcium phosphate–chitosan composite layers. Calcium phosphate layers were deposited on titanium substrates by radio-frequency magnetron sputtering technique by varying the substrate temperature from room temperature (25 °C) up to 100 and 300 °C. Further, chitosan was deposited by matrix-assisted pulsed laser evaporation technique on the calcium phosphate layers. The temperature at the substrate during the deposition process of calcium phosphate layers plays an important role in the embedding of chitosan, as scanning electron microscopy analysis showed. The degree of chitosan incorporation into the calcium phosphate layers significantly influence the physico-chemical properties and the adherence strength of the resulted layers to the substrates. For example, the decreases of Ca/P ratio at the addition of chitosan suggests that a calcium deficient hydroxyapatite structure is formed when the CaP layers are generated on Ti substrates kept at room temperature during the deposition process. The Fourier transform infrared spectroscopy analysis of the samples suggest that the PO43−/CO32− substitution is possible. The X-ray diffraction spectra indicated that the crystalline structure of the calcium phosphate layers obtained at the 300 °C substrate temperature is disturbed by the addition of chitosan. The adherence strength of the composite layers to the titanium substrates is diminished after the chitosan deposition. However, no complete exfoliation of the layers was observed.

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Bioprinted research models of urological malignancy

Wang,

Mao,

Wang

et al. 2024

Exploration

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Urological malignancy (UM) is among the leading threats to health care worldwide. Recent years have seen much investment in fundamental UM research, including mechanistic investigation, early diagnosis, immunotherapy, and nanomedicine. However, the results are not fully satisfactory. Bioprinted research models (BRMs) with programmed spatial structures and functions can serve as powerful research tools and are likely to disrupt traditional UM research paradigms. Herein, a comprehensive review of BRMs of UM is presented. It begins with a brief introduction and comparison of existing UM research models, emphasizing the advantages of BRMs, such as modeling real tissues and organs. Six kinds of mainstream bioprinting techniques used to fabricate such BRMs are summarized with examples. Thereafter, research advances in the applications of UM BRMs, such as culturing tumor spheroids and organoids, modeling cancer metastasis, mimicking the tumor microenvironment, constructing organ chips for drug screening, and isolating circulating tumor cells, are comprehensively discussed. At the end of this review, current challenges and future development directions of BRMs and UM are highlighted from the perspective of interdisciplinary science.

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Composite Coatings for Osteoblast Growth Attachment Fabricated by Matrix-Assisted Pulsed Laser Evaporation

Cited by 4 publications

References 73 publications

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Calcium Phosphates–Chitosan Composite Layers Obtained by Combining Radio-Frequency Magnetron Sputtering and Matrix-Assisted Pulsed Laser Evaporation Techniques

Bioprinted research models of urological malignancy

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