Composite Constituents : Aliphatics and Triterpenoids isolated from the whole Plants of Ixeris debilis and I. dentata

Arai, Yôko; Kusumoto, Yoko; Nagao, Megumi; Shiojima, Kenji; Ageta, Hiroyuki

doi:10.1248/yakushi1947.103.3_356

Cited by 18 publications

(3 citation statements)

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“…Ixeris dentata (ID) is an edible and officinal herb typically used for treatment of indigestion, pneumonia, hepatitis contusion, and tumors in Northeast Asia, including Korea [ 7 ]. It contains aliphatics, triterpenoids, cymaroside, and sesquiterpene glycosides [ 8 , 9 , 10 ], and has various physiological functions, including neuroprotective [ 11 ], anti-mutagenic [ 12 ], anti-hyperlipidemic [ 13 ], anti-inflammatory [ 14 ], anti-allergic [ 15 ], and anti-proliferative activities [ 16 ]. However, the anti-tumor effects of ID extract on human breast cancer cells are unknown.…”

Section: Introductionmentioning

confidence: 99%

Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways

Shin

Lee

Choo

et al. 2017

IJMS

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Ixeris dentata (Thunb. Ex Thunb.) Nakai (ID) exhibits various physiological activities, and its related plant derived-products are expected to represent promising cancer therapeutic agents. However, the anticancer effects of ID extract on breast cancer cells classified as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are still unknown. In this study, we investigated the anti-cancer effects and analyzed the molecular mechanism of ID extract in T47D, MCF-7 (ER-, PR-positive, HER2-negative), SK-BR-3(ER-, PR-negative, HER2-positive), and MDA-MB-231 (Triple-negative) through in vitro studies. Additionally, we examined its anti-tumor effects through in vivo studies. Our findings indicated that ID extract-induced apoptosis was mediated via various survival pathways on four breast cancer cells by identifying the factors including Bcl-2 family, phospho-Akt and phospho-nuclear factor-κB (NF-κB). Based on in vitro findings that induced apoptosis via Akt-NF-κB signaling, we investigated the effects of ID extract on mice bearing MDA-MB-231 cells. The results showed that ID extract significantly decreased MDA-MB-231 tumor volume and weight via inducing apoptosis by suppressing phospho-Akt. Overall, these results indicate that ID extract induces apoptosis through the Akt-NF-κB signaling pathway in MDA-MB-231 breast cancer cells and tumors, and it may serve as a therapeutic agent for triple-negative human breast cancer.

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Section: Introductionmentioning

confidence: 99%

Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways

Shin

Lee

Choo

et al. 2017

IJMS

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“…triterpenoid류 등이 존재하는 것으로 밝혀졌다 (Arai, 1983;Seto 등, 1986). 또한 식품학적으로 씀바귀와 같은 산채류 들에는 β-카로틴이나 비타민 C 등이 풍부하여 영양공급원 으로도 중요한 역할을 하는 것으로 보고되어 있다 (Ham, 1988).…”

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Changes in Anti-Oxidation and Sugar Degradation Enzyme Activities of Ixeris dentata NAKAI Extract with Gamma Irradiation

Park

Jung

Cho

2022

JKFN

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This study was designed to investigate the effects of different doses of gamma irradiation on the anti-oxidative activities, sugar degradation enzyme activity, and extraction yields of Ilxeris dentata NAKAI. Physical techniques to identify irradiation, namely photostimulated luminescence, thermoluminescence and electron spin resonance, confirmed that Ilxeris dentata NAKAI was gamma-irradiated. The total phenolics content (TPC) was higher in extracts from irradiated Ilxeris dentata NAKAI than from non-irradiated (0 kGy) samples. The inhibition of DPPH radical scavenging activity by water extracts from 0 kGy and 10 kGy irradiated Ilxeris dentata NAKAI was very high at over 80% each. The inhibition of ABTS radical cation activity by the water extracts from 0 kGy and 10 kGy irradiated Ilxeris dentata NAKAI was also very high at over 99% each, at 200 μg/mL TPC concentration. The antioxidant protection factor (PF) in the water extract from 10 kGy irradiated Ilxeris dentata NAKAI showed a very high level of activity at 1.41∼3.06 PF at 50∼200 μg/mL TPC concentrations. The thiobarbituric acid reactive substances in the water extract from 10 kGy irradiated Ilxeris dentata NAKAI showed high levels of 85.22∼98.57% inhibition at 50∼200 μg/mL TPC concentration. The pancreatin α-amylase inhibitory activities were high at 38.52∼100.00% at 50∼200 μg/mL TPC concentrations of water extract with 10 kGy irradiation doses. These results suggest an enhancement of extraction yields of phenolic compounds and biological activities from Ilxeris dentata NAKAI by gamma ray irradiation at 10 kGy. Also, treatment by gamma-irradiation can be used to amplify the solubility of biologically active compounds in plants.

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“…5 Clearly this compound, if it has the same absolute configuration as 1, could be either its direct precursor or one of its hydrolysis products. Together with 1, the known triterpene, lupenyl acetate (3), 6 was also isolated. This is the first report of this metabolite from a cyanobacterium.…”

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confidence: 99%

Mueggelone, a Novel Inhibitor of Fish Development from the Fresh Water Cyanobacterium Aphanizomenon flos-aquae

et al. 1997

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A novel C18 lipid, containing a 10-membered lactone, mueggelone (1), was isolated from a field-collected sample of Aphanizomenon flos-aquae, together with the known compound lupenyl acetate (3). Both structures were secured using extensive spectroscopic analysis (1D and 2D NMR, MS, IR). Biological activity assessment of both compounds indicated them to have significant inhibitory effects on fish embryo larval development.

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Composite Constituents : Aliphatics and Triterpenoids isolated from the whole Plants of Ixeris debilis and I. dentata

Cited by 18 publications

References 0 publications

Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways

Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways

Changes in Anti-Oxidation and Sugar Degradation Enzyme Activities of Ixeris dentata NAKAI Extract with Gamma Irradiation

Mueggelone, a Novel Inhibitor of Fish Development from the Fresh Water Cyanobacterium Aphanizomenon flos-aquae

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