“…Another recent development in drug delivery systems is cryogel, which is a modified form of hydrogel with the advantage of manipulating pore sizes, allowing for the passage of blood vessels and cells (Leach et al, 2019;Shah et al, 2019;Sultankulov et al, 2019b). It can be fabricated from both natural and synthetic polymers and has a wide range of tissue engineering applications, including bioreactors (Berillo et al, 2019), cell separation (Kumar and Srivastava, 2010), skin (Allan et al, 2016), cartilage (Han et al, 2016), bone (Kemençe and Bölgen, 2017;Sultankulov et al, 2019a), neural (Singh et al, 2018), and muscle tissue repair (Leach et al, 2019;Shah et al, 2019). Moreover, cryogels could be made using biopolymers with intrinsic antimicrobial activity, such as chitosan (Khan et al, 2019).…”