Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study

Yu, Yi‐Chuan; Paragomi, Pedram; Wang, Renwei; Jin, Aizhen; Schoen, Robert E.; Sheng, Li‐Ting; Pan, An; Koh, Woon‐Puay; Yuan, Jian‐Min; Luu, Hung N.

doi:10.1002/ijc.33925

Cited by 75 publications

(51 citation statements)

References 52 publications

(111 reference statements)

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“…Paragomi et al showed that the overall levels of dietary antioxidants decreased the risk of pancreatic cancer [ 34 ]. Yu et al reported an inverse relationship between CDAI and the risk of colorectal cancer, suggesting that antioxidants might reduce the incidence of colorectal cancer in the population [ 32 ]. Besides, dietary antioxidants were also reported to be associated with mortality, although not consistently.…”

Section: Discussionmentioning

confidence: 99%

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Composite Dietary Antioxidant Index and Plasma Levels of Soluble Klotho: Insights from NHANES

Chen

Miao

et al. 2023

Oxidative Medicine and Cellular Longevity

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Objectives. The association between dietary antioxidants and soluble Klotho (S-Klotho) levels remains unknown. We investigated to explore whether the composite dietary antioxidant index (CDAI) was associated with serum levels of S-Klotho in the middle-aged population. Methods. Eligible participants were identified from the National Health and Nutrition Examination Surveys (NHANES) from 2007 until 2016. The CDAI was calculated from the intake of six dietary antioxidants. The serum levels of S-Klotho were measured via enzyme-linked immunosorbent assay (ELISA). Generalized linear and nonlinear models were established to analyze the relationship between CDAI and S-Klotho levels. Results. Based on the S-Klotho quartiles, S-Klotho levels were higher in young women, Blacks, higher education, never smokers, lower waistlines, no medication use, and those with higher CDAI. Univariate analysis revealed that age, gender, race, smoking status, body mass index, waistline, and medication use were associated with serum levels of S-Klotho. When potential confounders were controlled, CDAI was significantly associated with S-Klotho levels. Subgroup analysis also revealed that this association remained significant in individuals who had the highest quartiles of CDAI, aged population (>60 years), male, and never smoker. A nonlinear relationship was observed between the CDAI and S-Klotho plasma concentrations. Conclusion. CDAI was positively correlated with plasma levels of S-Klotho after controlling for covariates. Further studies are needed to validate the current findings and explore the fundamental mechanisms.

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Section: Discussionmentioning

confidence: 99%

“…The CDAI was developed to evaluate and reflect the overall impact of dietary antioxidants on health. Previous studies found that high CDAI was related to a decreased risk of various types of cancer [ 32 – 34 ]. To our knowledge, the relationship between CDAI and plasma levels of Klotho has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Composite Dietary Antioxidant Index and Plasma Levels of Soluble Klotho: Insights from NHANES

Chen

Miao

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…In addition, because of their critical role in most diets worldwide, interest in the health effects of dietary total antioxidant capacity (TAC) is increasing. Previous studies found an inverse association between CDAI and cancer risk (8,9,11); however, similar efforts at cardiovascular mortality among the general population have not yet been conducted.…”

Section: Introductionmentioning

confidence: 94%

“…Including multiple dietary antioxidants such as manganese, zinc, selenium, and vitamins A and C, the Composite Dietary Antioxidant Index (CDAI) serves as a summary score for reflecting the antioxidant profile of individuals ( 8 , 9 ). CDAI was constructed in accordance with their aggregate anti-inflammatory impact based on markers like tumor necrosis factor-α and interleukin-1β ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Association of the Composite dietary antioxidant index with all-cause and cardiovascular mortality: A prospective cohort study

Wang

Zhong

2022

Front. Cardiovasc. Med.

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BackgroundAccording to epidemiological and experimental data, high individual dietary antioxidant intake is correlated with reduced cancer risk. The correlations between combined dietary antioxidants and the risk of all-cause and cardiovascular mortality remain unclear. Consequently, this study focused on evaluating the correlation between the food-derived Composite Dietary Antioxidant Index (CDAI) and all-cause and cardiovascular mortality.Materials and methodsTwo years of data collected from participants aged ≥20 years were included in this prospective cohort study, which was obtained from the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The US NHANES adopted a complicated, multistage probability sampling method to collect health data representing the US population. Data collection was done through in-person interviews, virtual physical examinations, and laboratory tests. Mortality-related follow-up statistics from the start of the survey to 31 December 2019 were available. The shape of the correlation between CDAI and all-cause and cardiovascular mortality was inspected using a restricted cubic spline model. For CDAI and all-cause and cardiovascular mortality, the univariate- and multivariate-adjusted Cox proportional hazard models were estimated and presented as regression coefficients and 95% confidence intervals.ResultsIn total, 44,031 NHANES participants represented 339.4 million non-institutionalized residents of the US (age, 47.2 ± 16.9 years; 52.5% women, 70.2% non-Hispanic whites, 10.8% non-Hispanic black people, and 7.5% Mexican Americans). In the 118-month follow-up, 9,249 deaths were reported, including 2,406 deaths resulting from heart disease and 519 deaths due to cerebrovascular disease. In the restricted cubic spline regression models, a linear relationship between CDAI and all-cause mortality was present. The weighted multivariate hazard ratios for all-cause mortality were computed to be 0.97 (0.87–1.07) for Q2, 0.88 (0.81–0.96) for Q3, and 0.90 (0.80–1.00) for Q4 (P for trend = 0.009) upon comparison with the lowest quartile of CDAI, and an identical trend was observed for cardiovascular mortality.ConclusionA high CDAI was linked to decreased all-cause and cardiovascular mortality risk. The intake of an antioxidant-rich diet significantly prevents cardiovascular mortality. To shed more light on these outcomes, more itemized investigations such as randomized control trials are required.

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“…The CDAI was developed based on its combined effect on anti-inflammatory effects based on the pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. (21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

Wang

et al. 2023

Front. Nutr.

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BackgroundThe Composite Dietary Antioxidant Index (CDAI), a composite score of multiple dietary antioxidants (including vitamin A, C, and E, selenium, zinc, and carotenoids), represents an individual’s comprehensive dietary antioxidant intake profile. CDAI was developed based on its combined effect on pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) and anti-inflammatory effects of Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. Handgrip strength is used as a simple measure of muscle strength, not only is it highly correlated with overall muscle strength, but also serves as a diagnostic tool for many adverse health outcomes, including sarcopenia and frailty syndromes.PurposeThe association between CDAI and Handgrip strength (HGS) is currently unclear. This study investigated the association between CDAI (including its components) and HGS in 6,019 American adults.MethodThe research data were selected from the 2011–2014 National Health and Nutrition Survey (NHANES), and a total of 6,019 American adults were screened and included. A weighted generalized linear regression model was used to evaluate CDAI (including its components) and HGS.Results(1) CDAI was significantly positively correlated with HGS (β = 0.009, 0.005∼0.013, P < 0.001), and the trend test showed that compared with the lowest quartile of CDAI, the highest quartile of CDAI was positively correlated with HGS (β = 0.084, 0.042∼0.126, P = 0.002) and significant in trend test (P for trend < 0.0100). Gender subgroup analysis showed that male CDAI was significantly positively correlated with HGS (β = 0.015, 0.007∼0.023, P = 0.002), and the trend test showed that compared with the lowest quartile of CDAI, the highest quartile of CDAI was positively correlated with HGS (β = 0.131, 0.049∼0.213, P = 0.006) and the trend test was significant (P for trend < 0.0100). There was no correlation between female CDAI and HGS, and the trend test was not statistically significant (P > 0.05). (2) The intake of dietary vitamin E, Zinc and Selenium showed a significant positive correlation with HGS (β = 0.004, 0.002∼0.007, P = 0.006; β = 0.007, 0.004∼0.009, P < 0.001; β = 0.001, 0.001∼0.001, P < 0.001), vitamin A, vitamin C and carotenoid were significantly associated with HGS in the Crude Model, but this significant association disappeared in the complete model with the increase of control variables. Gender subgroup analysis showed that in model 3, male dietary intake levels of vitamin E, Zinc, and Selenium were significantly positively correlated with HGS (β = 0.005, 0.002∼0.009, P = 0.011; β = 0.007, 0.004∼0.011, P = 0.001; β = 0.001, 0.001∼0.001, P = 0.004), the rest of the indicators had no significant correlation with HGS. Among the female subjects, dietary zinc intake was significantly positively correlated with HGS (β = 0.005, 0.001∼0.008, P = 0.008), and there was no significant correlation between other indicators and HGS (P > 0.05).ConclusionThere was an association between the CDAI and HGS, but there was a gender difference, and there was an association between the CDAI and HGS in male, but the association was not significant in female. Intake of the dietary antioxidants vitamin E, selenium, and zinc was associated with HGS in male, but only zinc was associated with HGS among dietary antioxidants in female.

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Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study

Cited by 75 publications

References 52 publications

Composite Dietary Antioxidant Index and Plasma Levels of Soluble Klotho: Insights from NHANES

Composite Dietary Antioxidant Index and Plasma Levels of Soluble Klotho: Insights from NHANES

Association of the Composite dietary antioxidant index with all-cause and cardiovascular mortality: A prospective cohort study

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

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