Composite silk fibroin hydrogel scaffolds for cartilage tissue regeneration

In this review, we discuss Nanotechnology models, which have been developed recently in cancer treatment. Nanotechnology manipulates matter at the atomic and molecular scale to create materials with new and advanced properties. Nano‐biotechnology consists of the branches of nanotechnology that have been applied in biology (molecular and cellular genetics) and biotechnology. Nano‐biotechnology allows us to put components and compounds into cells and build new materials using new methods like assembly. Cancer is a disease caused by an uncontrolled division of abnormal cells in a part of the body. Its therapeutic methods include chemotherapy, radiation, or surgery, but the effects of these techniques are not only on tumor tissue and may affect healthy tissues. Nano‐Biotech applications regarding cancer include drug delivery, treatment, and foresight therapy. This review article aims to obtain a proper mentality of the current technologies of Nano‐biotechnology for cancer treatment.

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“…Since serum proteins are negatively charged, hydrogels may be linked to serum proteins and reduce particle turnover. [41]…”

Section: Dendrimer Nanoparticlesmentioning

confidence: 99%

“…Hydrogels are naturally optimistic and thus may highly interfere with cell membranes with a negative charge and increase cell absorption. Since serum proteins are negatively charged, hydrogels may be linked to serum proteins and reduce particle turnover [41] …”

Section: Classification Of Nanoparticlesmentioning

confidence: 99%

Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

Asadipour

Asgari

Mousavi

et al. 2023

Chemistry & Biodiversity

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“…43,47 biodegradation, and cell adhesion, hybrid hydrogels are widely applied to improve the overall matrix in scaffold fabrication. [48][49][50] An ideal hydrogel candidate for scaffolding should have good biodegradability, extracellular matrix mimicry, desirable mechanical strength, and printability. Accessibility and commercial feasibility should also be considered for clinic use.…”

Section: Polymer Manipulated Hydrogelsmentioning

confidence: 99%

Sacrificial biomaterials in 3D fabrication of scaffolds for tissue engineering applications

Wang,

Zhou

2023

J Biomed Mater Res

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Three‐dimensional (3D) printing technology has progressed exceedingly in the area of tissue engineering. Despite the tremendous potential of 3D printing, building scaffolds with complex 3D structure, especially with soft materials, still exist as a challenge due to the low mechanical strength of the materials. Recently, sacrificial materials have emerged as a possible solution to address this issue, as they could serve as temporary support or templates to fabricate scaffolds with intricate geometries, porous structures, and interconnected channels without deformation or collapse. Here, we outline the various types of scaffold biomaterials with sacrificial materials, their pros and cons, and mechanisms behind the sacrificial material removal, compare the manufacturing methods such as salt leaching, electrospinning, injection‐molding, bioprinting with advantages and disadvantages, and discuss how sacrificial materials could be applied in tissue‐specific applications to achieve desired structures. We finally conclude with future challenges and potential research directions.

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“…It has been developed into kinds of material forms such as nanofibers, 18,19 microspheres, 20,21 hydrogels, 22,23 membranes, 24,25 and scaffolds 26,27 . The SF‐based hydrogel has good biocompatibility, biodegradability, and low immunogenicity for biomedical applications 28,29 . A SF‐based conductive hydrogel is commonly divided into three categories: ionic conductive hydrogels, carbon‐based conductive nanocomposite hydrogels (GO), and conductive polymer hydrogels (PPy, PEDOT: PSS, PCZ, etc.).…”

Section: Introductionmentioning

confidence: 99%

“…26,27 The SF-based hydrogel has good biocompatibility, biodegradability, and low immunogenicity for biomedical applications. 28,29 A SF-based conductive hydrogel is commonly divided into three categories: ionic conductive hydrogels, carbon-based conductive nanocomposite hydrogels (GO), and conductive polymer hydrogels (PPy, PEDOT: PSS, PCZ, etc.). Hydrogels are used as flexible sensors due to their excellent electrical conductivity.…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin‐based conductive and antibacterial hydrogels with a dual network for flexible sensors

Wang

Zeng

Wang

et al. 2023

J of Applied Polymer Sci

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The flexible wearable hydrogel strain sensors for human motion monitoring have attracted broad attention. However, developing a high‐strength hydrogel strain sensor remains challenging and achieves synergistic characteristics such as biocompatibility, antibacterial activity, and conductivity. This work proposes a two‐step UV polymerization method for the preparation of (hydrolyzed silk fibroin (HSF)/polyacrylamide (PAM)/polyacrylic acid (PAA)/poly sulfobetaine methacrylate (PSBMA) composite hydrogels. The monomers AM and AA undergo self‐polymerization and copolymerization. Meanwhile, SF is cross‐linked with them via multiple hydrogen bonds to form the first network. After the second UV initiation, SBMA polymerizes to create the second network. The HSF8%/PAM/PAA/PSBMA2% possesses superior tensile strength (1.49 ± 0.07 MPa) and compressive modulus (21.47 ± 1.07 MPa at 99% strain). The SBMA (4 wt%) endows hydrogels with antibacterial activity (98.53% ± 4.93%). The H+ ionized by PAA and the ion channels constructed by SBMA (4 wt%) provide hydrogel with ionic conductivity (0.950 S m−1). The hydrogel could be used as a flexible strain sensor to monitor human joint activity. The natural silk fibroin allows the hydrogel to retain degradability. Therefore, the SF‐based conductive hydrogel shows the potential application in flexible strain sensors.

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Composite silk fibroin hydrogel scaffolds for cartilage tissue regeneration

Cited by 18 publications

References 318 publications

Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

Sacrificial biomaterials in 3D fabrication of scaffolds for tissue engineering applications

Silk fibroin‐based conductive and antibacterial hydrogels with a dual network for flexible sensors

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