Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds

MAĞDEN>, Gamze KARA; Vural, Çiğdem; Bayrak, Büşra Yaprak; Özdoğan, Candan Yilmaz; Kenar, Halime

doi:10.1177/0885328220963897

Cited by 16 publications

(12 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The double‐layer AGS template was used as a simple regenerative device and allowed surgeons to perform a minimally invasive treatment procedure and achieve adequate granulation in an average of 2 weeks. Biological templates with sponge structures can serve as scaffolds for the regeneration of volumetric dermal or lower tissue loss without the tissue depression formation at the wound site 16 . Several in vivo experiments in animals indicated that wound dressings with sponge structures effectively promote the healing of full‐thickness skin wounds 16‐21 .…”

Section: Discussionmentioning

confidence: 99%

“…Biological templates with sponge structures can serve as scaffolds for the regeneration of volumetric dermal or lower tissue loss without the tissue depression formation at the wound site. 16 Several in vivo experiments in animals indicated that wound dressings with sponge structures effectively promote the healing of full‐thickness skin wounds. 16 , 17 , 18 , 19 , 20 , 21 Some studies have indicated that sponge structures can promote wound healing more effectively than gauze or traditional Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

“… 16 Several in vivo experiments in animals indicated that wound dressings with sponge structures effectively promote the healing of full‐thickness skin wounds. 16 , 17 , 18 , 19 , 20 , 21 Some studies have indicated that sponge structures can promote wound healing more effectively than gauze or traditional Chinese medicine. 22 In addition, the results of a previous study showed that a biological wound dressing with a composite sponge structure derived from sheep's small intestinal submucosa adhered uniformly to the wound and absorbed more wound exudation than polyurethane film.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Novel application of absorbable gelatine sponge combined with polyurethane film for dermal reconstruction of wounds with bone or tendon exposure

Pan

Hong

Chen

et al. 2022

International Wound Journal

View full text Add to dashboard Cite

Trauma, burns, and diabetes result in nonhealing wounds that can cause bone or tendon exposure, a significant health threat. The use of an artificial regeneration template combined with skin grafting as an alternative method to highly invasive flap surgery has been shown to be an effective way to cover full‐thickness skin defects with bone or tendon exposure for both functional and aesthetic recovery. However, artificial regeneration templates, such as Pelnac, are overwhelmingly expensive, limiting their clinical use. Here, we demonstrate for the first time that polyurethane film combined with absorbable gelatine sponge, affordable materials widely used for haemostasis, are effective for dermal reconstruction in wounds with bone or tendon exposure. The absorbable gelatine sponge combined with polyurethane film was applied to eight patients, all resulting in adequate granulation that fully covered the exposed bone or tendon. The outcome of absorbable gelatine sponge combined with polyurethane film application indicates that this approach is a potential novel and cost‐effective dermal reconstruction strategy for the treatment of severe wounds with bone or tendon exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Novel application of absorbable gelatine sponge combined with polyurethane film for dermal reconstruction of wounds with bone or tendon exposure

Pan

Hong

Chen

et al. 2022

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…SIS is a membranous ECM scaffold derived from porcine small intestine. It has attracted considerable attention in clinical applications for tissue regeneration, mainly because of the good capabilities of activating immune mediators, inducing angiogenesis, and promoting reepithelialization [7,43,44]. These effects are likely due to the release of growth factors, such as basic fibroblastic growth factor, transforming growth factorβ (TGF-β), and vascular endothelial growth factor (VEGF) [45,46].…”

Section: Small Intestinal Submucosa (Sis)mentioning

confidence: 99%

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Huang

Xie

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. Nevertheless, the wide clinical applications are always hindered by the poor mechanical properties, the uncontrollable degradation, and other factors after implantation. To highlight the feasible strategies to overcome the limitations, in this review, we first outline the current clinical use of traditional membranous ECM scaffolds for skin wound healing and briefly introduce the possible repair mechanisms; then, we discuss their potential limitations and further summarize recent advances in the scaffold modification and fabrication technologies that have been applied to engineer new ECM-based membranes. With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced ECM-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.

show abstract

“…So better or novel materials are needed in both the clinic and basic research, and with the rapid development of science and techniques in biomaterials science, natural materials have attracted more and more attention. Various new natural materials have been tested for their application as patches in clinics or basic researches, like the peritoneum-fascia patch (Sarac et al, 2005), small intestinal submucosal (SIS) graft (Magden et al, 2021), bovine and porcine pericardial patch (Bai et al, 2018a;Song et al, 2021), plant-derived patch (Bai et al, 2021a;Xie et al, 2021), fish swim bladder patch (Bai et al, 2021b), and biomimetic elastin fiber patch (Bai et al, 2021c). All these materials have some merits and drawbacks (Bai et al, 2021d).…”

Section: Introductionmentioning

confidence: 99%

Egg Shell Membrane as an Alternative Vascular Patch for Arterial Angioplasty

Sun

Yan

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Introduction: The egg shell membrane (ESM) is always considered as waste, but recent studies have shown that it has the potential to yield rapid re-endothelialization in vitro. We hypothesized that ESM and heparin-conjugated ESM (HESM) can be used as arterial patch in a rat aortic angioplasty model.Method: Sprague-Dawley rat (200 g) abdominal aortic patch angioplasty model was used. Decellularized rat thoracic aorta (TA) patch was used as the control; ESM patch was made of raw chicken egg; heparin-coated ESM (HESM) patch was made by using dopamine; anticoagulation properties were verified using platelet adhesion tests; the TA, ESM, and HESM patches were implanted to the rat aorta and harvested at day 14; and the samples were examined by immunohistochemistry and immunofluorescence.Result: The ESM patch showed a similar healing process to the TA patch; the cells could migrate and infiltrate into both patches; there was a neointima with von Willebrand factor-positive endothelial cells; the endothelial cells acquired arterial identity with Ephrin-B2- and dll-4-positive cells; there were proliferating cell nuclear antigen (PCNA)-positive cells, and PCNA and alpha smooth muscle actin dual-positive cells in the neointima in both groups. Heparin was conjugated to the patch successfully and showed a strong anticoagulation property in vitro. HESM could decrease mural thrombus formation after rat aortic patch angioplasty.Conclusion: The ESM is a natural scaffold that can be used as a vascular patch; it showed a similar healing process to decellularized TA patch; HESM showed anticoagulation property both in vitro and in vivo; and the ESM may be a promising vascular graft in the clinic.

show abstract

Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds

Cited by 16 publications

References 54 publications

Novel application of absorbable gelatine sponge combined with polyurethane film for dermal reconstruction of wounds with bone or tendon exposure

Novel application of absorbable gelatine sponge combined with polyurethane film for dermal reconstruction of wounds with bone or tendon exposure

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Egg Shell Membrane as an Alternative Vascular Patch for Arterial Angioplasty

Contact Info

Product

Resources

About