Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds

Liu, Ying; Tian, Yue; Zheng, Wenshu; Yan, Feng; Huang, Rong; Shao, Jianzhong; Tang, Rongbing; Wang, Peng; Jia, Yuexiao; Zhang, Jiangjiang; Zheng, Wenfu; Yang, Guang; Jiang, Xingyu

doi:10.1002/smll.201700130

Cited by 128 publications

(77 citation statements)

References 31 publications

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“…28,29 This finding might of course also be a disadvantage of the material itself because it exhibits no antimicrobial activity. However, biosynthetic cellulose 26 has been combined with zinc oxide, 30 silver nanoparticles, 10,31,32 or even gold 33 in vitro to prevent bacterial growth, and possibly this would also exert antimicrobial properties in vivo . The ability of biosynthetic cellulose to be combined with antimicrobial agents could be utilized to further control infections in the future to limit the use of systemic antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns

Karlsson

Olofsson

Steinvall

et al. 2019

Advances in Wound Care

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Objective: The use of porcine xenograft (PX) is widely spread in burn care. However, it may cause immunologic responses and other ethical and cultural considerations in different cultures. Therefore, there is a need for alternatives. The aim of this work is to test a novel biosynthetic cellulose dressing (Epiprotect ® ) on burn patients. Approach: Charts from 38 patients with superficial burns (SBs) ( n = 18) or excised burns ( n = 20) that got biosynthetic cellulose dressing instead of PX at a national burn center during 3 years were reviewed. Time to healing, length of stay, and wound infection were extracted from the medical records. Results: SBs hospitalization time was 11 days comparable to PXs reported by others. In the excised group, median duration of hospital stay was 35 days. Time to healing was 28 days. Seven wound infections were confirmed in the superficial group (39%) and 11 infections in the excised group (61%). Patients with superficial wounds reported pain relief on application. Innovation: A dressing (17 × 21 cm) consisting of biosynthetic cellulose replacing PX. Conclusion: Outcome of treatment of SBs or temporary coverage of excised deep burns with biosynthetic cellulose is comparable to treatment with PX. However, biosynthetic cellulose has benefits such as providing pain relief on application and ethical or cultural issues with the material is nonexistent.

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Section: Discussionmentioning

confidence: 99%

Three Years' Experience of a Novel Biosynthetic Cellulose Dressing in Burns

Karlsson

Olofsson

Steinvall

et al. 2019

Advances in Wound Care

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“…Gold nanoparticle BC composites were said to present better efficacy than most of the antibiotics against gram‐negative bacteria, while preserving outstanding physicochemical properties such as water uptake capacity, high mechanical strain and biocompatibility. The broad antibacterial spectrum of these composites along with the desirable moisture retention and the good mechanical properties enables them as an excellent material for wound dressing (Li et al ., ). TiO 2 nanoparticles are known for their super‐hydrophilic, chemical stability and biocompatibility (Fujishima et al ., ).…”

Section: Bacterial Cellulose Compositesmentioning

confidence: 97%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

434

271

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Summary Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical–chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC‐based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.

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“…When a BC membrane is soaked in Au-DAPT solution, Au-DAPT can adsorb on the BC membrane by physical adsorption which results in an antibacterial dressing (BC-Au-DAPT nanocomposites) for wound healing. 94 The freezedried BC-Au-DAPT nanocomposites are highly stable and retain their antibacterial activity aer one year of storage. Another application of the AuNP-based antibiotics is their use as antibacterial coatings for medical devices.…”

Section: Small Molecule-modied Aunps As Antibioticsmentioning

confidence: 99%