Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L.

Khlifi, Daycem; Sghaier, Rabiaa M.; Amouri, Sameh; Laouini, Dhafer; Hamdi, Moktar; Bouajila, Jalloul

doi:10.1016/j.fct.2013.01.004

Cited by 173 publications

(107 citation statements)

References 42 publications

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“…The discrepancies between our results and those of Khlifi et al (2013) may be due to the differences in the concentration of the used plant extracts. In our study, we used extracts with higher concentrations than those used by Khlifi et al (2013).…”

Section: Discussioncontrasting

confidence: 95%

“…Our findings are consistent with those of Singh et al (2011) who showed that the ethanolic extracts of A. annua from Chinese and Brazilian origins were cytotoxic to human leukocyte cultures. On the other hand, Khlifi et al (2013) found that the methanolic extract of A. herba-alba showed no toxicity against human blood mononuclear cell cultures. The discrepancies between our results and those of Khlifi et al (2013) may be due to the differences in the concentration of the used plant extracts.…”

Section: Discussionmentioning

confidence: 98%

“…On the other hand, Khlifi et al (2013) found that the methanolic extract of A. herba-alba showed no toxicity against human blood mononuclear cell cultures. The discrepancies between our results and those of Khlifi et al (2013) may be due to the differences in the concentration of the used plant extracts. In our study, we used extracts with higher concentrations than those used by Khlifi et al (2013).…”

Section: Discussionmentioning

confidence: 98%

“…Finally, the ethanolic extract of A. herba-alba reduced the viability of HCT116 colon cancer cells in a dose and time dependent manner (Lupidi et al 2011), and the methanolic extract of this plant showed growth inhibitory effect on RT112 (bladder), Hep2 (larynx), and K562 (leukemia) cell lines in a dose dependent manner (Khlifi et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In the first study, Lupidi et al (2011) showed that the exposure of a cell line of human colon cancer to the ethanolic extract of the plant decreased cell viability, caused DNA damage, and induced apoptosis. In the other study, Khlifi et al (2013) demonstrated that the methanolic extracts of A. herba-alba had cytotoxic effect against three human cancer cell lines: bladder carcinoma, laryngeal carcinoma, and myelogenous leukemia. In contrast, the plant extract did not show any cytotoxicity against the normal peripheral blood mononuclear cells.…”

Section: Introductionmentioning

confidence: 94%

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Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Abderrahman

Shbailat

2014

Caryologia

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Artemisia herba-alba is a medicinal plant that is commonly used in folk remedies in the Middle East. Despite its wide use, little is known about whether or not it is genotoxic and/or cytotoxic to mammalian cells. Here we investigated the genotoxic and cytotoxic effects of the ethanolic plant extract on mice cells at different dose concentrations (125, 250, 375, and 500 μg ml ) and for different exposure times (12, 24, 48, and 72 h). We found that at all exposure times, treatment with high dose concentrations (375 and 500 μg ml ) of A. herba-alba extract significantly reduced cell division in mice bone marrow cells compared to that in the control cells. Also, it induced sister chromatid exchanges and micronuclei formation in bone marrow and peripheral blood cells, respectively. Moreover, high dose concentrations significantly reduced cell viability in bone marrow cell cultures compared to that in the controls. The IC 50 values were 484.38, 513.33, and 490.39 μg ml −1 after 24, 48, and 72 h of exposure, respectively. Our findings reveal that A. herba-alba extract has both genotoxic and cytotoxic effects on mammalian cells, particularly at high concentrations. Therefore, we suggest that the plant extract should not be used at high concentrations in folk medicine.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Abderrahman

Shbailat

2014

Caryologia

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Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Tshikhudo,

Mabhaudhi,

Koorbanally

et al. 2024

Chemistry & Biodiversity

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This comprehensive review is designed to evaluate the anticancer properties of β‐carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability and potential in cancer treatment, management, and prevention. An exhaustive literature survey was conducted on a wide array of β‐carbolines including, but not limited to, harmaline, harmine, harmicine, harman, harmol, harmalol, pinoline, tetrahydroharmine, tryptoline, cordysinin C, cordysinin D, norharmane, and perlolyrine. Various analytical techniques were employed to identify and screen these compounds, followed by a detailed analysis of their anticancer mechanisms. Natural β‐carbolines such as harmaline and harmine have shown promising inhibitory effects on the growth of cancer cells, as evidenced by multiple in vitro and in vivo studies. Synthetically derived β‐carbolines also displayed noteworthy anticancer, neuroprotective, and cognitive‐enhancing effects. The current body of research emphasizes the potential of β‐carbolines as a unique source of bioactive compounds for cancer treatment. The diverse range of β‐carbolines derived from medicinal plants can offer valuable insights into the development of new therapeutic strategies for cancer management and prevention.

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Phytochemical Profile, Antioxidant, Anti‐Alzheimer, And α‐Glucosidase Inhibitory Effect Of Algerian Peganum harmala Seeds Extract

Benramdane,

Benariba,

Silva

et al. 2024

Chemistry & Biodiversity

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Peganum harmala seeds crude hydro‐methanolic extract and their fractions (obtained with ethyl acetate and butan‐1‐ol) were analyzed and compared for their chemical profiles of alkaloids and polyphenols content. Moreover, their antioxidant, a‐glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitory activities were evaluated. The butan‐1‐ol fraction revealed the highest total phenolic content and exhibited the highest antioxidant capacity. From the inhibitory enzyme evaluations, it should be highlighted the butan‐1‐ol fraction inhibitory potential of ɑ‐glucosidase (the IC50= 141.18±4μg/mL), which was better than the acarbose inhibitory effect (IC50= 203.41±1.07 μg/mL). The extracts' chemical profile analysis revealed several compounds, in which quercetin dimethyl ether, harmine and harmaline emerged as the major compounds. The different solvents used impacted Peganum harmala seed contents and biological responses. Statistical analysis showed a significant correlation between bioactive compounds and biological activities. Thus, Peganum harmala seeds could be a promising natural source of bioactive compounds at the crossroads of many human diseases, and its cultivation may be encouraged.

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Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L.

Cited by 173 publications

References 42 publications

Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Phytochemical Profile, Antioxidant, Anti‐Alzheimer, And α‐Glucosidase Inhibitory Effect Of Algerian Peganum harmala Seeds Extract

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