Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis

Al-Ja'fari, Abdel-Hadi; Vila, Roser; Freixa, Blanca; Tomi, Félix; Casanova, Joseph; Costa, Joan; Cañigueral, Salvador

doi:10.1016/j.phytochem.2011.04.013

Cited by 53 publications

(21 citation statements)

References 31 publications

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“…The different compounds in the extract may be working in synergy to kill the parasite by providing an arsenal to multiple drug targets. For example, the present essential oil contains corymbolone (a sesquiterpene) and spathulenol which have been shown to exhibit anti-plasmodial [12] and antifungal [23,24], activities, respectively. Further studies are required to narrow down to the antifilarial principles in the essential oil.…”

Section: Discussionmentioning

confidence: 99%

Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L

Metuge

Nyongbela

Mbah

et al. 2014

BMC Complement Altern Med

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BackgroundThe lack of a safe and effective adult worm drug and the emergence of resistant animal parasite strains to the only recommended drug, the microfilaricide, ivermectin put many at risk of the devastating effects of the onchocerciasis. The present study was undertaken to investigate the acclaimed anti-Onchocerca activity of the roots/rhizomes of Cyperus articulatus in the traditional treatment of onchocerciasis in North Western Cameroon and to assess the plant as a new source of potential filaricidal lead compounds.MethodsCrude extracts were prepared from the dried plant parts using hexane, methylene chloride and methanol. The antifilarial activity was evaluated in vitro on microfilariae (Mfs) and adult worms of the bovine derived Onchocerca ochengi, a close relative of Onchocerca volvulus. The viabilities of microfilariae and adult male worms were determined based on motility reduction, while for the adult female worms the viability was based on the standard MTT/formazan assay. Cytotoxicity of the active extract was assessed on monkey kidney epithelial cells in vitro and the selectivity indices (SI) were determined. Acute toxicity of the promising extract was investigated in mice. Chemical composition of the active extract was unraveled by GC/MS analysis.ResultsOnly the hexane extract, an essential oil exhibited anti-Onchocerca activity. The oil killed both the microfilariae and adult worms of O. ochengi in a dose manner dependently, with IC50s of 23.4 μg/ml on the Mfs, 23.4 μg/ml on adult male worms and 31.25 μg/ml on the adult female worms. Selectivity indices were 4, 4, and 2.99 for Mfs, adult males and adult females, respectively. At a single limit dose of 2000 mg/kg body weight, none of 6 mice that received the essential oil by gavage died. GC/MS analysis revealed the presence of terpenoids, hydrocarbons and fatty acids or fatty acid derivatives as components of the oil.ConclusionsThe essential oil from the roots/rhizomes of Cyperus articulatus is active against O. ochengi microfilariae and adult worms in vitro in a dose dependent manner, hence may provide a source of new anti-filarial compounds. The results also support the traditional use of C. articulatus in the treatment of human onchocerciasis.

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Section: Discussionmentioning

confidence: 99%

Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L

Metuge

Nyongbela

Mbah

et al. 2014

BMC Complement Altern Med

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“…Due to their efficient antifungal and antibacterial activity [4]–[7], essential oils have been widely used in cosmetic, sanitary, and agricultural and food industries [8]. For example, Litsea cubeba , an evergreen tree grown fast and widely in Southern China, Japan and Southeastern Asia, is a traditional Chinese medicine for curing inflammation, headache and intoxication [9], [10].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Kinetics of Litsea cubeba Oil on Escherichia coli

Shi

Liang

et al. 2014

PLoS ONE

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Litsea cubeba oil is extracted from the fresh fruits of Litsea cubeba by distillation. In this study, its chemical constituents, antibacterial activity, kinetics and effects against Escherichia coli were studied. Its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were both 0.125% (v/v) by toxic food method. Moreover, the antibacterial kinetic curves indicated 0.0625% (v/v) of litsea cubeba oil was able to prolong the growth lag phase of E. coli cells to approximate 12 hours while 0.125% (v/v) of litsea cubeba oil was able to kill the cells completely. Furthermore, transmission electron microscope (TEM) observation showed most E. coli cells treated with 0.125% (v/v) of litsea cubeba oil were killed or destroyed severely within 2 hours. The litsea cubeba oil might penetrate and destroy the outer and inner membrane of E. coli cells. Thus many holes and gaps were observed on the damaged cells, which led to their death eventually. The antibacterial effects of litsea cubeba oil mainly attributed to the presence of aldehydes, which accounted for approximately 70% in its whole components analyzed by GC/MS. Based on the antimicrobial properties, litsea cubeba oil would have a broad application in the antimicrobial industry.

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“…α‐Pinene (2,6,6‐trimethyl‐bicyclo3.1.1‐2‐heptene) is a member of the homologous terpene series found in a variety of plant essential oils and volatiles (Negahban et al., ; Al‐Ja'Fari et al., ; Tozlu et al., ). Liu et al.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological and laboratory behavioral responses of a leaf beetle pest of elm, Ambrostoma quadriimpressum, to selected plant volatiles and essential oils

Wang

Chi

2017

Entomologia Exp Applicata

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The leaf beetle Ambrostoma quadriimpressum Motschulsky (Coleoptera: Chrysomelidae) is distributed in China, Siberia, and elsewhere in northeastern Asia. This pest feeds only on buds and leaves of elm trees (Ulmaceae) and inhibits elm trees sprouting, increasing the risk of damage and destruction by other pests. We investigated selected plant compounds that could be used for the development of semiochemical‐based push‐pull methods for the control of this elm pest. Electroantennogram (EAG), Y‐tube olfactometer, and wind tunnel bioassays were conducted to test the electrophysiological and behavioral response of A. quadriimpressum to nine individual volatiles and five essential oils. Individual volatiles and essential oils were selected based on their activity against insects in previous studies. The individual volatiles and essential oils were dissolved in dichloromethane and adsorbed by filter paper. Using a pipette, odor stimuli were delivered as 0.5‐s puffs of air into a continuously humidified air stream in the odor delivery tube at 400 ml per min. Ambrostoma quadriimpressum adults display strong EAG responses to l mol l−1 isoeugenol, (1R)‐(+)‐α‐pinene, 1% pepper oil (derived from the pericarp of Piper chinense Miq.), and peppermint oil [derived from the aerial parts of Mentha haplocalyx (Briq.)] compared to the control. In behavioral assays conducted using a Y‐tube olfactometer and a wind tunnel, adult beetles were attracted by (1R)‐(+)‐α‐pinene but repelled by 0.1% pepper oil. The results provide a basis for the development of a ‘push‐pull’ strategy to manage A. quadriimpressum.

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Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis

Cited by 53 publications

References 31 publications

Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L

Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L

Antibacterial Activity and Kinetics of Litsea cubeba Oil on Escherichia coli

Electrophysiological and laboratory behavioral responses of a leaf beetle pest of elm, Ambrostoma quadriimpressum, to selected plant volatiles and essential oils

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