Composition and Antimicrobial Activity of the Essential Oil ofThymus fontanesii.

Abstract

The yield of oil isolated by hydrodistillation from aerial parts of Thymus fontanesii Boiss. et Reut. (Lamiaceae) growing wild in Djelfa (Algeria) was 0.9%. Analysis of the oil by gas chromatography (GC) and gas chromato-graphy=mass spectrometry (GC=MS) revealed the identification of 47 components accounting for 98.5% of the total oil. The oil was found to be rich in monoterpenes (91.5%) with major constituents being thymol (29.3%), c-terpinene (21.7%), p-cymene (15.9%), and thymol methyl ether (11.4%), while a smaller amount of linalool (4.8%) and b-caryophyllene (2.9%) were detected. According to the antimicrobial study using the disk diffusion method and the agar dilution assay-minimal inhibitory concentration (MIC), the oil showed strong in vitro growth inhibition activity against Gram-negative bacteria and antifungal activity. The oil exhibited the maximum antifungal activity against Mucor ramaniamus (MIC ¼ 0.2 mL=mL).

Anti-inflammatory activity of essential oil of an endemicThymus fontanesiiBoiss. & Reut. with chemotype carvacrol, and its healing capacity on gastric lesions

“…However, the same plant gives an essential oil whose composition differs according to the localization; indeed, the major constituents are linalool at 43.3%, thymol at 29.2%, and p‐cymene at 6.8% in the region of Djelfa, while in the region of Setif the major compound is Thymol. (67.8%) followed by γ‐terpinene (15.9%) and p‐cymene (13.0%) (Dob, Dahmane, Benabdelkader, & Chelghoum, ; Ghannadi, Sajjadi, Kabouche, & Kabouche, ). The investigation of Djouahri et al proved that the geographic origin of the plants has a significant effect on their chemical composition (Djouahri, Saka, Boudarene, & Baaliouamer, ).…”

“…gives an essential oil whose composition differs according to the localization; indeed, the major constituents are linalool at 43.3%, thymol at 29.2%, and p-cymene at 6.8% in the region of Djelfa, while in the region of Setif the major compound is Thymol. (67.8%) followed by g-terpinene (15.9%) and p-cymene (13.0%) (Dob, Dahmane, Benabdelkader, & Chelghoum, 2006;Ghannadi, Sajjadi, Kabouche, & Kabouche, 2004…”

GC/MS analysis and in vitro antioxidant activity of essential oil and methanol extracts of Thymus caramanicus Jalas and its main constituent carvacrol

“…These species have also been used as carminative, diuretic, urinary disinfectant and vermifuge (Matta et al, 2007). The antioxidant and antimicrobial activity of members of the genus Thymus, including the wellknown specie, Thymus vulgaris, has been widely reported (Dob, Dahmane, Benabdelkader, & Chelghoum, 2006;Marino, Bersani, & Comi, 1999;Ryman, 1992;Schwarz, Ernst, & Ternes, 1996). The essential oils and extracts of many Thymus species are widely used in pharmaceutical, cosmetic and perfume industry, and for flavouring and preservation of several food products (Bauer, Garbe, & Surburg, 1997).…”

Chemical Composition and Antioxidant Activity of Thymus fontanesii Essential Oil from Algeria

“…Thymus fontanesii essential oil (TFEO) revealed that carvacrol and thymol represent the most important compounds in the species flowed by p-cymene and γterpinene [5][6][7][8][9]. Concerning the biological properties of T. fontanesii essential oil, there are some studies on the antimicrobial activity [7][8][9], antidermatophytic activity [10] and anti-inflammatory activity [6,8], but there are not studies on their antioxidant activity.…”