Composition and antioxidant activity of the biopolymer complex from Spirulina platensis (Nordst.) Geitl.

Ovsyannikova, Tatyana; Миронова, Наталія Геннадіївна; Zabolotny, V. N.; Губанова, А.Г.; Polishchuk, L. Ya.; Vinogradova, G. Yu.; Zabelina, L. A.; Karpenko, N. A.

doi:10.1615/interjalgae.v2.i1.80

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“…It is known that unlike fullerenes, the bluegreen alga Spirulina platensis in the form of powders, tablets, capsules, and the like has antioxidant properties that enables it to be used for the correction of pro-and antioxidant balance in the body (Ovsyannikova et al, 1998;Mazokopakis et al, 2014;Wu et al, 2016). We believe that the use of modulators of free radical processes of fullerenes in combination with the cell culture of Spirulina platensis, having an undoubted antioxidant effect, is promising for the development of effective and safe drugs.…”

Section: Introductionmentioning

confidence: 99%

Membrane-modifying properties of hydrated fullerene C60 in combination with Spirulina platensis cell culture

Ovsyannikova¹,

Falko²,

Kovalenko³

et al. 2019

biologija

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The study is devoted to the development of new promising nanocomponent compositions with membrane-modulating properties. The effect of a solution of hydrated fullerene C60 and a cell suspension of blue-green algae Spirulina platensis on the activity of free radical lipid peroxidation and oxidative phosphorylation in mitochondria of rat liver was studied. Fullerene C60 and suspension of Spirulina platensis cells were administered to Wistar rats for 30 days, once a day, intragastrically, both jointly and singly. The rate of oxygen consumption of phosphorylating and non-phosphorylating mitochondria (in V3 and V4 states), the rate and efficiency of ADP phosphorylation (ADP/Δt and ADP/O), respiratory control coefficient (RC) were changed in rat liver mitochondria. In the same samples, the concentration of diene, triene, oxodiene, and tetraene fatty acids was measured. The results of our studies have shown that the solution of hydrated fullerene C60 serves as a structural modifier of the lipid bilayer of cell membranes, the effect of which can be corrected by using an antioxidant component such as a suspension of Spirulina platensis cells.

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Section: Introductionmentioning

confidence: 99%