Composition and Bioactivity of Essential Oil from Citrus grandis (L.) Osbeck ‘Mato Peiyu’ Leaf

Tsai, Max; Lin, C J; Khoo, Keh Ai; Wang, Meiying; Kuan, Tsang-Kuei; Lin, Wen‐Tai; Zhang, Yanan; Wang, Yaying

doi:10.3390/molecules22122154

Cited by 38 publications

(42 citation statements)

References 77 publications

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“…Comparing to others studies, anti‐tyrosinase activity of A iva EOs was more important than that of Chinese Rubus pungenes EO with IC 50 = 923 µg/mL 45 and less than that of Taiwanese Citrus grandis EO with IC 50 of 7.77 µg/mL, 46 , 44 have reported interesting elastase inhibitory activity by Helichrzsum italicum EO with IC 50 of 135.43 µg/mL. Indeed, in most instances, it was difficult to compare the anti‐tyrosinase and anti‐elastase activities with previous studies because of differences in result expressions.…”

Section: Resultscontrasting

confidence: 61%

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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Ajuga iva (A iva) is a medicinal plant used mainly in traditional medicine. This study was aimed to identify the volatile compounds of A iva essential oils (AIEO) at three developmental periods, and to evaluate their pharmacological properties. Chemical volatile compounds were identified by GC/MS analysis. Twenty‐eight volatile components were identified, belonging mainly to oxygenated monoterpenes and hydrocarbons monoterpenes. Carvacrol, octadecane, methyl chavicol were the major volatile components of AIEO at the three phenological stages. FRAP, DPPH and ABTS assays were adopted to estimate the antioxidant effects. AIEO at the vegetative stage exhibited important antioxidant effects with IC50 = 52.43 μg/mL (DPPH), IC50 = 115.22 μg/mL (FRAP), and, IC50 = 143.40 μg/mL (ABTS). The antidiabetic activity was evaluated in vitro by the inhibition of α‐amylase and α‐glucosidase. AIEO at the vegetative stage was the most active as an enzyme inhibitor of α‐amylase (IC50 = 101.727 μg/mL) and α‐glucosidase (IC50 = 86.93 μg/mL). The dermatoprotective effect was investigated by the in vitro inhibition of tyrosinase and elastase activities. AIEO at the vegetative stage showed the lowest IC50 inhibition values against tyrosinase (IC50 = 87.49 μg/mL) and elastase (IC50 = 192.21 μg/mL). Antifungal properties of AIEO were investigated on Trichophyton violaceum, T tonsurans and T mentagrophytes. The three EOs of A iva exhibited important inhibitions of the tested dermatophytes. The findings of this work showed that phenological stages affect significantly the volatile compounds of A iva, and these fluctuations influence mainly the biological properties. Moreover, further investigations concerning in vivo pharmacodynamic and pharmacokinetic investigations as well as clinical trials of these identified compounds could develop antidiabetic, dermatoprotective and anti‐dermatophyte drugs.

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Section: Resultscontrasting

confidence: 61%

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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“…The EO of Citrus maxima (syn. Citrus grandis, contains citronellal and citronellol) and citronellal have been described to inhibit 5-lipoxygenase activity [27]. Geraniol, the other main component of LO used in our study, reduced MPO activity and pro-inflammatory cytokines production in vivo in an LPS-evoked acute lung injury model [15].…”

Section: Discussionmentioning

confidence: 64%

Effects of Thymus vulgaris L., Cinnamomum verum J.Presl and Cymbopogon nardus (L.) Rendle Essential Oils in the Endotoxin-induced Acute Airway Inflammation Mouse Model

et al. 2020

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Thyme (TO), cinnamon (CO), and Ceylon type lemongrass (LO) essential oils (EOs) are commonly used for inhalation. However, their effects and mechanisms on inflammatory processes are not well-documented, and the number of in vivo data that would be important to determine their potential benefits or risks is low. Therefore, we analyzed the chemical composition and investigated the activity of TO, CO, and LO on airway functions and inflammatory parameters in an acute pneumonitis mouse model. The components of commercially available EOs were measured by gas chromatography–mass spectrometry. Airway inflammation was induced by intratracheal endotoxin administration in mice. EOs were inhaled during the experiments. Airway function and hyperresponsiveness were determined by unrestrained whole-body plethysmography on conscious animals. Myeloperoxidase (MPO) activity was measured by spectrophotometry from lung tissue homogenates, from which semiquantitative histopathological scores were assessed. The main components of TO, CO, and LO were thymol, cinnamaldehyde, and citronellal, respectively. We provide here the first evidence that TO and CO reduce inflammatory airway hyperresponsiveness and certain cellular inflammatory parameters, so they can potentially be considered as adjuvant treatments in respiratory inflammatory conditions. In contrast, Ceylon type LO inhalation might have an irritant effect (e.g., increased airway hyperresponsiveness and MPO activity) on the inflamed airways, and therefore should be avoided.

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“…Hence, this could explain other major chemical compositions found in EOCW, as the one reported in the Anand region, northeast India, whose main constituents were citronellol (34.25%), linalool (27.47%), citronellal (11.52%), and emelol (11.15%) [ 42 ]. Based on the antioxidant [ 22 , 23 , 24 ], anti-inflammatory [ 19 , 25 ], and antifibrotic [ 26 ] properties of this essential oil, we designed the first study on the potential activity of the EOCW on bleomycin-induced pulmonary fibrosis in a rodent model. In addition, the doses (50, 100, and 200 mg/kg) were chosen according to the study previously conducted by Leite et al (2011) [ 19 ], using EOCW of the same region, with a similar major chemical composition.…”

Section: Discussionmentioning

confidence: 99%

“…These biological properties are potentially attributed to its the major monoterpenes, namely, geraniol (40.06%), citronellal (27.44%), and citronellol (10.45%) [ 21 ]. In fact, geraniol reduces pro-oxidative lipid peroxidation and nitric oxide (NO) and reactive oxygen species (ROS) production [ 22 ], whereas citronellal inhibits pro-inflammatory 5-lipoxygenase (5-LOX) synthesis [ 23 ]. Citronellol inhibits inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, resulting in antioxidant and anti-inflammatory effects [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Cymbopogon winterianus Essential Oil Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Murine Model

et al. 2021

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The essential oil of Cymbopogon winterianus (EOCW) is a natural product with antioxidant, anti-inflammatory, and antifibrotic properties. We studied the effect of EOCW in the progression of histological changes of pulmonary fibrosis (PF) in a rodent model. The oil was obtained by hydrodistillation and characterized using gas chromatography–mass spectrometry. Intratracheal instillation of bleomycin was performed in 30 rats to induce PF, while Sham animals were subjected to instillation of saline solution. The treatment was performed using daily oral administration of distilled water, EOCW at 50, 100, and 200 mg/kg, and deflazacort (DFC). After 28 days, hemogram and bronchoalveolar lavage fluid (BALF), tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were assayed. Histological grading of PF, immunohistochemical expression of α-smooth muscle actin (α-SMA), and transforming growth factor-β (TGF-β) were also analyzed. The EOCW major compounds were found to be citronellal, geraniol, and citronellol. EOCW significantly reduced inflammation in BALF, reduced MDA levels, and increased SOD activity. EOCW attenuated histological grading of PF and reduced immunohistochemical expression of α-SMA and TGF-β in a dose-dependent way, likely due to the reduction of oxidative stress, inflammation, and TGF-β-induced myofibroblast differentiation.

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Composition and Bioactivity of Essential Oil from Citrus grandis (L.) Osbeck ‘Mato Peiyu’ Leaf

Cited by 38 publications

References 77 publications

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Effects of Thymus vulgaris L., Cinnamomum verum J.Presl and Cymbopogon nardus (L.) Rendle Essential Oils in the Endotoxin-induced Acute Airway Inflammation Mouse Model

Cymbopogon winterianus Essential Oil Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Murine Model

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