Composition and biological properties of mucins, isolated from human submandibular glands

Oemrawsingh, I.; Roukema, P.A.

doi:10.1016/0003-9969(74)90162-9

Cited by 25 publications

(13 citation statements)

References 22 publications

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“…Early studies indicated that salivary mucins interact with influenza virus (Oemrawsingh and Roukema, 1974), which was correlated with the sialic acid content of the mucin. Gibbons and co-workers were among the first to describe a salivary bacterial agglutinin (Gibbons and Spinell, 1970), found to be highmolecular-weight, blood group-reactive sialoglycoproteins (Hay et al, 1971).…”

Section: Mucinsmentioning

confidence: 99%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

286

250

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Saliva is thought to have a significant impact on the colonization of microorganisms in the oral cavity. Salivary components may participate in this process by one of four general mechanisms: binding to microorganisms to facilitate their clearance from the oral cavity, serving as receptors in oral pellicles for microbial adhesion to host surfaces, inhibiting microbial growth or mediating microbial killing, and serving as microbial nutritional substrates. This article reviews information pertinent to the molecular interaction of salivary components with bacteria (primarily the oral streptococci and Actinomyces) and explores the implications of these interactions for oral bacterial colonization and dental plaque formation. Knowledge of the molecular mechanisms controlling bacterial colonization of the oral cavity may suggest methods to prevent not only dental plaque formation but also serious medical infections that may follow microbial colonization of the oral cavity.

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Section: Mucinsmentioning

confidence: 99%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

286

250

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“…Biochemical studies have demonstrated considerable variability in the structure of saccharide moieties in glycoprotein secretions from submandibular glands of different animals (Bertolini and Pigman, 1970;Gottschalk and Bhargava, 1972;Keryer et al, 1973;Oemrawsingh and Roukema, 1974;Roukema et al, 1976;Downs et al, 1976;Pigman, 1977;Herp et al, 1979;Denny et al, 1980;Fleming et al, 1982). Such investigations have also shown heterogeneity in the structure of submandibular mucins isolated from a single species (Bertolini and Pigman, 1970;Oemrawsingh and Roukema, 1974;Pigman, 1977;Herp et al, 1979).…”

mentioning

confidence: 92%

“…Such investigations have also shown heterogeneity in the structure of submandibular mucins isolated from a single species (Bertolini and Pigman, 1970;Oemrawsingh and Roukema, 1974;Pigman, 1977;Herp et al, 1979). Although these analytical studies have provided detailed chemical information about the content and (in some cases) the sequence of sugar residues in saccharide side-chains, they have failed to reveal the precise cellular or subcellular sites from which the structurally diverse glycoconjugates originate.…”

mentioning

confidence: 95%

Genetic and Sex-related Differences in the Structure of Submandibular Glycoconjugates

Schulte

1987

J Dent Res

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Structures of oligosaccharides in submandibular glycoproteins were evaluated in situ. Sections of fixed paraffin-embedded glands from rats, mice, hamsters, sheep, and man were stained with a battery of lectins conjugated to horseradish peroxidase in conjunction with other methods, such as digestion with sialidase with or without prior saponification and/or periodate oxidation. Secretory glycoproteins showed a characteristic lectin binding pattern for each genus. Sialoglycoconjugates were detected in acinar cell secretions in all genera except the rat but differed with respect to the linkage of sialic acid to penultimate beta-galactose or alpha-N-acetylgalactosamine. Species and strains of mice showed minor differences in the structure of secretory glycoproteins. Sexes differed similarly in some but not other mouse species. Individual differences were seen in human glands, where oligosaccharide structure varied in relation to ABO blood group. In some species, heterogeneity in glycoprotein structure was observed among morphologically similar cells within a gland. Differences in the structure of salivary secretions between genera and between humans of different ABO blood type and secretor status substantiate biochemical and histochemical findings. The results showing species, sex, and individual differences in mice and heterogeneity in acinar cells in several species suggest a greater degree of genetic and perhaps hormonal influence on the synthesis of salivary glycoproteins than has previously been recognized.

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“…There is indirect evidence, for example, that the rheological properties and solubility of mucus depend strongly on interactions of mucins with other luminal constituents such as lipids (55,94), nucleic acids (55), inorganic acid and alkalis (12,47,56), salts (46,56), serum proteins (47,55,133), and enzymes (6,56,116). There is also evidence for significant interaction of mucins with orally administered drugs (78).…”

Section: B Physical and Functional Propertiesmentioning

confidence: 99%

“…taminants'. It has now been proposed by many investigators (30,53,54,57,88,99,116,133) that mucins are cross-linked in vivo by non-glycosylated peptides, which differ from the common peptide core of mucins by being low in concen tration and relatively rich in aspartic, glutamic and cysteine residues. The latter engage in disulfide bond formation, and in some mucins, these bonds appear to link mucin into large aggregates.…”

Section: Degradation O F Mucinmentioning

confidence: 99%

Intestinal Mucins in Health and Disease

Jf¹

1978

Digestion

252

115

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Intestinal mucins are complex glycoproteins which are secreted from goblet cells, and form a gel-like covering over the mucosal surface. They are assumed to provide lubrication and protection of the underlying epithelium against potentially injurious chemicals, enzymes, bacteria and dietary constituents. Recent advances in our understanding of mucin structure, secretion and functional properties are reviewed in this paper. Implications for diseases such as cystic fibrosis, peptic ulcer, malignancy and inflammatory bowel disease are briefly discussed.

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Composition and biological properties of mucins, isolated from human submandibular glands

Cited by 25 publications

References 22 publications

Saliva-Bacterium Interactions in Oral Microbial Ecology

Saliva-Bacterium Interactions in Oral Microbial Ecology

Genetic and Sex-related Differences in the Structure of Submandibular Glycoconjugates

Intestinal Mucins in Health and Disease

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