Composition and Chemistry of Functional Foods and Nutraceuticals: Influence on Bioaccessibility and Bioavailability

Jacob, Jissy K.; Paliyath, Gopinadhan

doi:10.1002/9780470960844.ch5

Cited by 2 publications

(1 citation statement)

References 122 publications

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“…In several human trials, fruit polyphenols have been found to down regulate pro-inflammatory cytokines and chemokines [ 45 , 46 , 47 ]. Thus, dietary antioxidants are potent candidates for use as bioactives to enhance the function of the antioxidant defense system during normal living conditions thus preventing inflammation and decreasing the chance of developing cancer [ 48 , 49 ].…”

Section: Plant Bioactives and Targeting Antioxidant Pathwaysmentioning

confidence: 99%

Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds

Nosrati

Bakovic

Paliyath

2017

IJMS

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A unique feature of bioactive food ingredients is their broad antioxidant function. Antioxidants having a wide spectrum of chemical structure and activity beyond basic nutrition; display different health benefits by the prevention and progression of chronic diseases. Functional food components are capable of enhancing the natural antioxidant defense system by scavenging reactive oxygen and nitrogen species, protecting and repairing DNA damage, as well as modulating the signal transduction pathways and gene expression. Major pathways affected by bioactive food ingredients include the pro-inflammatory pathways regulated by nuclear factor kappa B (NF-κB), as well as those associated with cytokines and chemokines. The present review summarizes the importance of plant bioactives and their roles in the regulation of inflammatory pathways. Bioactives influence several physiological processes such as gene expression, cell cycle regulation, cell proliferation, cell migration, etc., resulting in cancer prevention. Cancer initiation is associated with changes in metabolic pathways such as glucose metabolism, and the effect of bioactives in normalizing this process has been provided. Initiation and progression of inflammatory bowel diseases (IBD) which increase the chances of developing of colorectal cancers can be downregulated by plant bioactives. Several aspects of the potential roles of microRNAs and epigenetic modifications in the development of cancers have also been presented.

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Section: Plant Bioactives and Targeting Antioxidant Pathwaysmentioning

confidence: 99%

Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds

Nosrati

Bakovic

Paliyath

2017

IJMS

Self Cite

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Biochemical Basis for Functional Ingredient Design from Fruits

Jacob

Tiwari

Correa-Betanzo

et al. 2012

Annu. Rev. Food Sci. Technol.

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Functional food ingredients (nutraceuticals) in fruits range from small molecular components, such as the secondary plant products, to macromolecular entities, e.g., pectin and cellulose, that provide several health benefits. In fruits, the most visible functional ingredients are the color components anthocyanins and carotenoids. In addition, several other secondary plant products, including terpenes, show health beneficial activities. A common feature of several functional ingredients is their antioxidant function. For example, reactive oxygen species (ROS) can be oxidized and stabilized by flavonoid components, and the flavonoid radical can undergo electron rearrangement stabilizing the flavonoid radical. Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the gene transcription of antioxidant enzymes. Carotenoids and flavonoids can also exert their action by modulating the signal transduction and gene expression within the cell. Recent results suggest that these activities are primarily responsible for the health benefits associated with the consumption of fruits and vegetables.

show abstract

Composition and Chemistry of Functional Foods and Nutraceuticals: Influence on Bioaccessibility and Bioavailability

Cited by 2 publications

References 122 publications

Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds

Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds

Biochemical Basis for Functional Ingredient Design from Fruits

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