Composition and fatty acid content of rat ventral prostate phospholipids

Pulido, J.A.; Hoyo, N. del; Pérez-Albarsanz, M.A.

doi:10.1016/0005-2760(86)90265-1

Cited by 15 publications

(8 citation statements)

References 24 publications

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“…As yet, such a comprehensive study has not been undertaken. In fact, already a few previous studies have dealt with the composition of phospholipids and fatty acids in homogenate of human and rat prostatic tissue [16][17][18][19]. However, in those studies the prostatic tissue has not been separated in epithelium and stroma.…”

Section: Discussionmentioning

confidence: 97%

“…This holds also true regarding the two unidentified peaks. In their study on the phospholipid fatty acid composition in rat ventral prostate, Pulido et al [19] described the presence of three unidentified peaks. Two of these peaks, again detectable at highest levels in phosphatidylethanolamine, showed a retention time comparable to that of the unidentified peaks A and B in our analysis.…”

Section: Discussionmentioning

confidence: 97%

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Fatty acid composition of phospholipids in epithelium and stroma of human benign prostatic hyperplasia

Weisser

Krieg

1998

Prostate

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Fatty acid composition of phospholipids in epithelium and stroma of human benign prostatic hyperplasia

Weisser

Krieg

1998

Prostate

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“…The polyunsaturated fatty acids offer a vulnerable target for many of these oxidizing species (130)(131)(132), forming lipid radicals and hydroperoxides that can generate additional oxygen radicals and/or DNA damage (133)(134)(135). Semen can be highly oxidizing due to the presence of leukocytes as well as of significant quantities of polyunsaturated fatty acids (including the prostaglandin precursor arachidonic acid and associated vinyl ethers) in prostatic tissue and fluid (136,137). The presence of oxidized fatty acids in cellular membranes can affect membrane and protein function; consequently, cells have evolved mechanisms to repair damaged membrane phospolipids.…”

Section: Cellular Fat Dna Damage and Carcinogenesismentioning

confidence: 99%

“…Although membrane fatty acid levels can be altered somewhat by dietary manipulation (22), there is much evidence to suggest that cells regulate membrane composition of fatty acids to meet specific cellular needs, either through selection of particular fatty acids or by regulating synthesis of essential fatty acids (23). Temperature has been identified as one variable that can affect fatty acid composition in adipose tissue, allowing cells to maintain membrane fluidity despite variation in external temperature (24).…”

mentioning

confidence: 99%

Dietary Fat and Prostate Cancer: Current Status

Kolonel¹,

Nomura²,

Cooney³

1999

JNCI Journal of the National Cancer Institute

214

118

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Efforts to elucidate the causes of prostate cancer have met with little success to date. All that is known with certainty is that the incidence increases exponentially with age, varies by geography and by race or ethnicity, and is higher among men whose father or brother had the disease. Because the incidence changes in migrants and their offspring, exogenous factors certainly contribute to the risk of prostate cancer. Early epidemiologic studies implicated dietary fat as a likely causal factor for this cancer. However, scientific support for such an association has diminished in recent years as more epidemiologic evidence has accrued. Accordingly, we reviewed the relevant English language literature on this topic, including epidemiologic and animal studies, as well as current concepts regarding the involvement of fat in carcinogenesis to re-examine the fat-prostate cancer hypothesis. We conclude that dietary fat may indeed be related to prostate cancer risk, although the specific fat components that are responsible are not yet clear. Given the diverse effects of fatty acids on cellular biology and chemistry, it seems likely that the relationship is complex, involving the interplay of fat with other dietary factors, such as antioxidant vitamins and minerals, or with genetic factors that influence susceptibility. Some suggestions for further research are offered.

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“…Serine ether GPL (PSe; i.e., alkyl-acyl serine GPL; Figure 1 ) and serine plasmalogens (PSp; i.e., alkenyl-acyl serine GPL), have been reported from studies of human retina and optic nerve ( Nagy et al, 2012 ), human lens ( Deeley et al, 2008 , 2009 ; Ellis et al, 2010 ), rat prostate ( Pulido et al, 1986 ), the mouse macrophage cell line RAW 264.7 ( Ivanova et al, 2010 ), gills of bivalves ( Kraffe et al, 2004 ), the fungus pneumocystis carinii ( Kaneshiro et al, 1998 ), a number of bacteria ( van Golde et al, 1973 ; Oe et al, 2008 ; Rezanka et al, 2011 ), murine mamillary tumors ( Sekar et al, 2022 ), and coral ( Imbs and Velansky, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Serine ether glycerophospholipids: Decrements in the frontal cortex associated with mild cognitive impairment and Alzheimer’s disease

Wood

Woltjer

2022

Front. Aging Neurosci.

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Ether glycerophospholipids (GPL) are involved in membrane fluidity and fusion. Vinyl-ether GPL are also conjectured to provide antioxidant capacity in the brain. The roles of these lipids in the processes involved in the development of dementia are not understood but choline and ethanolamine vinyl-ether GPL (i.e., plasmalogens) are decreased in the brains of subjects with dementia. In contrast, serine ether and vinyl-ether GPL have not been investigated in human brain. We therefore undertook an evaluation of these lipids, utilizing high-resolution mass spectrometry (HR-MS), in tissues from control and dementia subjects that we had previously characterized in-depth. We can report for the first time that a number of serine ether GPL and a more limited number of serine plasmalogens are present in human frontal cortex. In addition, we found that some of these frontal cortex lipids are decreased in Mild Cognitive Impairment (MCI), early-onset Alzheimer’s disease (EOAD), and late-onset AD (LOAD). In contrast no alterations in serine ether GPL were monitored in the frontal cortex of donors with schizophrenia, demonstrating disease specificity. These data suggest that further studies of the roles of ether GPL, including serine ether GPL, in brain function are worthy of undertaking.

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Composition and fatty acid content of rat ventral prostate phospholipids

Cited by 15 publications

References 24 publications

Fatty acid composition of phospholipids in epithelium and stroma of human benign prostatic hyperplasia

Fatty acid composition of phospholipids in epithelium and stroma of human benign prostatic hyperplasia

Dietary Fat and Prostate Cancer: Current Status

Serine ether glycerophospholipids: Decrements in the frontal cortex associated with mild cognitive impairment and Alzheimer’s disease

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