Composition and functional roles of the gut microbiota in mosquitoes

Strand, Michael R.

doi:10.1016/j.cois.2018.05.008

Cited by 108 publications

(96 citation statements)

References 72 publications

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“…Mosquitoes harbor very complex, abundant and dynamic microbial communities that are found at high concentrations in the different intestinal portions (Dillon and Dillon, 2004;Engel and Moran, 2013). These micro-organisms are comprised of protozoans, fungi, bacteria and viruses (Guegan et al, 2018b;Strand, 2018). The combination of the host and its associated microbiota is referred to as the holobiont.…”

Section: Effects Of Temperature On Microbiotamentioning

confidence: 99%

The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission

Bellone

Failloux

2020

Front. Microbiol.

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Mosquito-borne diseases having the greatest impact on human health are typically prevalent in the tropical belt of the world. However, these diseases are conquering temperate regions, raising the question of the role of temperature on their dynamics and expansion. Temperature is one of the most significant abiotic factors affecting, in many ways, insect vectors and the pathogens they transmit. Here, we debate the veracity of this claim by synthesizing current knowledge on the effects of temperature on arboviruses and their vectors, as well as the outcome of their interactions.

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Section: Effects Of Temperature On Microbiotamentioning

confidence: 99%

The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission

Bellone

Failloux

2020

Front. Microbiol.

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“…In this review, we focus on prokaryotes and eukaryotic microbes. The mosquito gut microbiota is mainly acquired from the environment (Wang et al, 2017;Strand, 2018), and its composition is highly dynamic, varying greatly with species, nutrition, stage of mosquito development, and geography (Tchioffo et al, 2015;Minard et al, 2017;Novakova et al, 2017;Bascunan et al, 2018;Krajacich et al, 2018;Muturi et al, 2018;Telang et al, 2018;Duguma et al, 2019). Sequencing of the 16S rRNA or18S rRNA hypervariable regions is used as a culture-independent approach to study mosquito microbiota composition (Pidiyar et al, 2004;Belda et al, 2017).…”

Section: Gut Microbiota Diversity and Distribution In Mosquitoesmentioning

confidence: 99%

Use of Microbiota to Fight Mosquito-Borne Disease

2020

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Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide-and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgently needed. In recent years, the use of mosquito microbiota has shown great potential for cutting down transmission of mosquito-borne pathogens. Here we review what is known about the mosquito microbiota and how this knowledge is being used to develop new ways to control mosquito-borne disease. We also discuss the challenges for the eventual release of genetically modified (GM) symbionts in the field.

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“…Members of these microbial communities have obligate relationships with mosquitoes and are maintained vertically through mosquito generations (Guégan et al, 2018) or acquired from the environment (Engel and Moran, 2013;Strand 2017). The microbiome of mosquitoes have been shown to help maintain normal midgut functions, as well as interfering or aiding vector competence of the mosquito (Strand, 2018;Jayme et al, 2019). As previously shown, pathogen susceptibility and vector competence of an arthropod can be modulated by the microbial composition within the arthropod vector (Bonnet et al, 2017).…”

Section: Introductionmentioning

confidence: 98%

Laboratory colonization by Dirofilaria immitis alters the microbiome of female Aedes aegypti mosquitoes

Adegoke

Neff

Geary

et al. 2020

Preprint

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Background: The ability of blood feeding arthropods to successfully acquire and transmit pathogens of medical and veterinary importance has been shown to be interfered or enhanced by the arthropod’s native microbiome. Mosquitoes transmit bacteria, viruses, protozoan and filarial nematodes, majority of which contributes to the 17% of infectious disease cases worldwide. Dirofilaria immitis, a mosquito transmitted filarial nematodes of dogs and cats, is vectored by several mosquito species including Aedes aegypti.Methods: In this study, we investigated the impact of D. immitis colonization on the microbiome of laboratory reared female A. aegypti. Metagenomic analysis of the V3-V4 variable region of the microbial 16SRNA was used for identification of the microbial differences down to species level.Results: We generated a total of 1068 OTUs representing 16 phyla, 181 genera and 271 bacterial species. Overall, in order of abundance, Proteobacteria, Bacteroidetes, Actinobacteria and Firmicutes were the most represented phylum with D. immitis infected mosquitoes having more of Proteobacteria (71%) than uninfected mosquitoes (56.9%). An interesting finding in this study is the detection of Klebsiella oxytoca in relatively similar abundance in infected and uninfected mosquitoes. It has been previously shown to indirectly compete for nutrients with fungi on the domestic housefly eggs and larva. While not statistically significant, D. immitis infection alters bacterial diversity by reducing the bacterial species richness and abundance.Conclusions: In conclusion, this is the first study to the best of our knowledge to understand the impact of a filarial infection on the microbiome of its mosquito vector. While the microbiome composition of A. aegypti mosquito have been previously reported, our study shows that in an effort to establish itself, a filarial nematode modifies and alters the overall microbial diversity within its mosquito host.

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Composition and functional roles of the gut microbiota in mosquitoes

Cited by 108 publications

References 72 publications

The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission

The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission

Use of Microbiota to Fight Mosquito-Borne Disease

Laboratory colonization by Dirofilaria immitis alters the microbiome of female Aedes aegypti mosquitoes

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