Composition and micromechanical properties of the femoral neck compact bone in relation to patient age, sex and hip fracture occurrence

Bone collagen tensile properties of the aging human proximal femur

“…Other ρ MM Raman band ratios (v 1 PO 4 /amide I) were also shown to be independent of donor age at death ( Boivin and Meunier, 2002 ; Gamsjaeger et al, 2014 ; Mirzaali et al, 2016 ; Unal et al, 2019 ). A similar absence of correlation with the donor's age at death for X c is in line with other studies ( Kochetkova et al, 2023 ; Makowski et al, 2015 ; Mirzaali et al, 2016 ). In contrast to our observations ( r = 0.01, p > 0.05), the matrix maturity ratio is expected to increase with age, following available studies ( Kochetkova et al, 2023 ; Unal et al, 2019 ).…”

“…A similar absence of correlation with the donor's age at death for X c is in line with other studies ( Kochetkova et al, 2023 ; Makowski et al, 2015 ; Mirzaali et al, 2016 ). In contrast to our observations ( r = 0.01, p > 0.05), the matrix maturity ratio is expected to increase with age, following available studies ( Kochetkova et al, 2023 ; Unal et al, 2019 ). However, we have a narrower range of the donor's age at death, which may diminish potential correlation.…”

“…Raman spectroscopy showed that ρ MM , X c , and matrix maturity ratio did not vary with donor age at death. With respect to ρ MM , this confirms results gathered by Kochetkova et al ( Kochetkova et al, 2023 ). Other ρ MM Raman band ratios (v 1 PO 4 /amide I) were also shown to be independent of donor age at death ( Boivin and Meunier, 2002 ; Gamsjaeger et al, 2014 ; Mirzaali et al, 2016 ; Unal et al, 2019 ).…”

“…ρ MM correlated positively with ( r = 0.35, p < 0.01). This is in line with the site-matched measurements carried on Raman microspectroscopy and nanoindentation ( Indermaur et al, 2023 , Indermaur et al, 2021 ; Kochetkova et al, 2023 ). A matching negative correlation was observed between X c vs. elastic moduli and collagen disorder/order ratio vs. (for both r = −0.23, p < 0.05), suggesting a hidden interplay of the mineral and organic bone fraction into the output bone mechanical properties.…”

“…However, the presented compositional properties were averaged from the local measurements. Acquired values of the relative bone composition were generally in line with previous studies on Raman micro spectrometers: 0.4–1.6 mineral-to-matrix ratio ( Kochetkova et al, 2023 ; Roschger et al, 2014 ), 0.05–0.06 mineral crystallinity ( Kochetkova et al, 2023 ; Mirzaali et al, 2016 ; Yerramshetty and Akkus, 2008 ), 1.35–1.60 collagen disorder/order ratio ( Unal et al, 2019 , Unal et al, 2016 ), 1.40–1.47 matrix maturity ratio ( Kochetkova et al, 2023 ).…”