Composition and mutagenicity of PAHs associated with urban airborne particles in Córdoba, Argentina

Carreras, Hebe Alejandra; Calderón-Segura, María Elena; Gómez‐Arroyo, Sandra; Murillo-Tovar, Mario Alfonso; Amador-Muñóz, Omar

doi:10.1016/j.envpol.2013.03.016

Cited by 64 publications

(32 citation statements)

References 47 publications

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“…Recent findings have shown that organic compounds adsorbed on the surface of airborne particles, such as polycyclic aromatic hydrocarbons (PAHs), can induce oxidative stress and cancer (Carreras et al 2013;Risom et al 2005;Xue and Warshawsky 2005). In addition, PAHs have been Guillermo Benjamín Silva died last november.…”

Section: Introductionmentioning

confidence: 99%

Organic compounds present in airborne particles stimulate superoxide production and DNA fragmentation: role of NOX and xanthine oxidase in animal tissues

Busso

Silva

Carreras

2016

Environ Sci Pollut Res

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Suspended particulate matter trigger the production of reactive oxygen species. However, most of the studies dealing with oxidative damage of airborne particles focus on the effects of individual compounds and not real mixtures. In order to study the enzymatic superoxide production resulting from the exposition to a complex mixture, we derived organic extracts from airborne particles collected daily in an urban area and exposed kidney, liver, and heart mammal tissues. After that, we measured DNA damage employing the comet assay. We observed that in every tissue, NADPH oxidase and xanthine oxidase were involved in O2 (-) production when they were exposed to the organic extracts, as the lucigenin's chemiluminescence decays when enzymes were inhibited. The same trend was observed with the percentage of cells with comets, since DNA damage was higher when they were exposed to same experimental conditions. Our data allow us to hypothesize that these enzymes play an important role in the oxidative stress produced by PAHs and that there is a mechanism involving them in the O2 (-)generation.

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Section: Introductionmentioning

confidence: 99%

Organic compounds present in airborne particles stimulate superoxide production and DNA fragmentation: role of NOX and xanthine oxidase in animal tissues

Busso

Silva

Carreras

2016

Environ Sci Pollut Res

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“…The genotoxicity assay with T. pallida can be used as a screening tool to assess human risk under unfavorable environmental conditions (Sisenando et al, 2011;Carreras et al, 2013). The influence of weather conditions such as relative humidity, temperature and rainfall on the Trad-MCN assay as a result of exposure to genotoxic agents has been investigated by a number of studies (Klumpp et al, 2004;Savóia et al, 2009;Sisenando et al, 2011;Pereira et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…An appropriate alternative to the environmental conditions found in tropical countries is the use of Tradescantia pallida. Several studies have demonstrated its sensitivity to the genotoxic compounds from air pollutants in situ (Batalha et al, 1999;Guimarães et al, 2000;Carreras et al, 2006;Prajapati and Tripathi, 2008;Mariani et al, 2009;Meireles et al, 2009;Savóia et al, 2009;Sisenando et al, 2011;Pereira et al, 2013) and ex situ (Carvalho-Oliveira et al, 2005;Alves et al, 2011Alves et al, , 2014Carreras et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cashew nut roasting: Chemical characterization of particulate matter and genotocixity analysis

Galvão

Cabral

André

et al. 2014

Environmental Research

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“…purpurea plants exposed in urban environments corroborate data reported by Costa and Droste (2012), who observed MCN frequencies from 3.26 to 8.13 in Estância Velha, a municipality with leader and footwear industrial activity in the lower section of the Sinos River Basin. Savóia et al (2009) (Carreras et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Despite this, the majority of risk assessment studies of atmospheric pollutants are based on concentrations detected by chemical analyses for simple substances and the synergic and genotoxic effects of complex mixtures of these compounds are still poorly known (Savóia et al, 2009;Merlo et al, 2011). Over recent years, studies have begun to integrate biological indicators with physical and chemical parameters, with the goal of identifying genetic changes that may occur in organisms as a result of the environmental conditions in which they live or after exposure as active indicators in environments that are supposedly polluted (Meireles et al, 2009;Savóia et al, 2009;Carreras et al, 2013;Pereira et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Biomonitoring the genotoxic potential of the air on Tradescantia pallida var. purpurea under climatic conditions in the Sinos River basin, Rio Grande do Sul, Brazil

et al. 2015

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The present study evaluated the genotoxic effects of the atmospheric air on Tradescantia pallida var. purpurea in urban areas with different intensities of vehicular traffic and in riparian forest fragments in the Sinos River Basin (Rio Grande do Sul, Brazil), considering the influence of climatic conditions prevailing in these environments. Bimonthly, from May 2012 to March 2013, cuttings with flower buds were exposed for 8 h in urban and riparian forest environments in the municipalities of Caraá, Taquara and Campo Bom in the upper, middle and lower sections, respectively, of the Sinos River Basin. Simultaneously, negative controls were made and climatic data were recorded. Micronuclei (MCN) frequencies were determined in young tetrads of pollen mother cells and expressed as MCN/100 tetrads. Significantly higher MCN frequencies were observed in buds exposed in urban and riparian forest environments in Taquara (up to 7.23 and 4.80, respectively) and Campo Bom (up to 4.90 and 4.23, respectively) than in buds exposed in Caraá (up to 2.90 and 2.50, respectively), in the majority of samplings, and in relation to the negative control (up to 1.93) in all months. Over the course of the period monitored, there were significant variations in MCN frequencies at all sampling points, with the exception of the urban environment in Caraá. For the urban environments, relation between the MCN frequency, vehicular traffic and mean temperature was observed. For the riparian forest fragments, there was no association between MCN frequency and climatic factors. Tradescantia pallida var. purpurea can be considered a useful tool to point out areas with increased atmospheric pollution, since the exposure of plants under severe climatic conditions is avoided to minimize their negative influence on the formation of micronuclei.Keywords: abiotic factors, vehicular emissions, bioindicator, environmental quality, micronucleus. Biomonitoramento do potencial genotóxico do ar em

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Composition and mutagenicity of PAHs associated with urban airborne particles in Córdoba, Argentina

Cited by 64 publications

References 47 publications

Organic compounds present in airborne particles stimulate superoxide production and DNA fragmentation: role of NOX and xanthine oxidase in animal tissues

Organic compounds present in airborne particles stimulate superoxide production and DNA fragmentation: role of NOX and xanthine oxidase in animal tissues

Cashew nut roasting: Chemical characterization of particulate matter and genotocixity analysis

Biomonitoring the genotoxic potential of the air on Tradescantia pallida var. purpurea under climatic conditions in the Sinos River basin, Rio Grande do Sul, Brazil

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