Point-of-use (POU) system is the treatment process aimed to treat only water intended for direct consumption (drinking and cooking), typically at a single tap or limited number of taps. Point-of-entry (POE) treatment devices are typically installed to treat all water entering a single home, business, school, or facility. Reverse osmosis (RO) is recognized by the industry as one of the top POU and POE treatment technologies. This chapter describes the advantages and limitations in using RO for POU and POE applications. Types and configurations of reverse osmosis, and installation, operation and maintenance, and testing of RO are also included.