Composition controlled synthesis of PCL–PEG Janus nanoparticles: magnetite nanoparticles prepared from one-pot photo-click reaction

Khoee, Sepideh; Bagheri, Yousef; Hashemi, Ayoub

doi:10.1039/c4nr06590e

Cited by 29 publications

(15 citation statements)

References 38 publications

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“…To control the surface properties of SPIONs, they are coated with a biocompatible polymer during or after the synthesis process, which prevents the formation of large aggregates, changes from the original structure, and biodegradation when exposed to the biological system. In addition, polymer coating can allow binding of drugs by covalent attachment, adsorption, or entrapment on the particles [142].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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In recent decades, magnetic iron nanoparticles (NPs) have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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“…To achieve this, azide-terminated polystyrene and poly(4-vinylpyridine) were synthesized and then the polymers were anchored onto alkyne-modified SiO 2 NPs by CuAAC [113]. Magnetic core-brush nanoparticles were also synthetized by “click” chemistry [114,115,116,117,118,119]. Tudisco et al [114] reported MNPs that were surface modified with phosphate containing alkyne terminals for subsequent covalent binding via “click” chemistry of PEG chains and Tiiii receptors (Figure 9).…”

Section: Core-brush Nanoparticlesmentioning

confidence: 99%

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

2018

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Hybrid nanomaterials based on inorganic nanoparticles and polymers are highly interesting structures since they combine synergistically the advantageous physical-chemical properties of both inorganic and polymeric components, providing superior functionality to the final material. These unique properties motivate the intensive study of these materials from a multidisciplinary view with the aim of finding novel applications in technological and biomedical fields. Choosing a specific synthetic methodology that allows for control over the surface composition and its architecture, enables not only the examination of the structure/property relationships, but, more importantly, the design of more efficient nanodevices for therapy and diagnosis in nanomedicine. The current review categorizes hybrid nanomaterials into three types of architectures: core-brush, hybrid nanogels, and core-shell. We focus on the analysis of the synthetic approaches that lead to the formation of each type of architecture. Furthermore, most recent advances in therapy and diagnosis applications and some inherent challenges of these materials are herein reviewed.

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“…Compared with the spectrum of SI, the SI‐MPS exhibits new sulfur peaks (S 2s and S 2p) with binding energies of 228 and 164 eV (Figure S2b, Supporting Information) and the CS bonds at 285.4 eV (Figure S2d, Supporting Information), indicating that the mercapto‐groups were immobilized onto the SI nanoparticles surface probably by the ligand exchange of the silanetriol molecules with the initially attached weak stabilizers. [ 48,49 ] The oleic acid (OA)‐capped CdSe/CdS/ZnS QDs with 8 nm diameter (Figure 3b) were directly assembled with SI‐MPS templates in non‐polar solvent driven by the coordination between metal atoms and alkanethiol. Figure 3d illustrates that the QDs were compactly immobilized in the pore channels of SI templates.…”

Section: Resultsmentioning

confidence: 99%

Compact Magneto‐Fluorescent Colloids by Hierarchical Assembly of Dual‐Components in Radial Channels for Sensitive Point‐of‐Care Immunoassay

Huang

Zhang

Liao

et al. 2021

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Exploring signal amplification strategies to enhance the sensitivity of lateral flow immunoassay (LFIA) is of great significance for point-of-care (POC) testing of low-concentrated targets in the field of in vitro diagnostics. Here, a highly-sensitive LFIA platform using compact and hierarchical magnetofluorescent assemblies as both target-enrichment substrates and optical sensing labels is demonstrated. The large-pored dendritic templates are utilized for high-density incorporation of both superparamagnetic iron oxide nanoparticles (IOs) and quantum dots (QDs) within the vertical channels. The hierarchical structure is built via affinity-driven assembly of IOs and QDs from organic phase with silica surface and mercapto-organosilica intermediate layer, respectively. The sequential assembly with central-radial channels enables 3D loading of dual components and separately controlling of discrete functionalities. After the alkyl-organosilica encapsulation and silica sealing, the composite spheres exhibit high stabilities and compatibility with LFIA for procalcitonin (PCT) detection. With the assistance of liquid-phase antigen-capturing, magnetic enrichment, and fluorescence-signal amplification, a limit of detection of 0.031 ng mL −1 for PCT is achieved with a linear range from 0.012 to 10 ng mL −1 . The current LFIA is robust and validated for PCT detection in real serum, which holds great diagnostic significance for precise guidance of antibiotic therapy with POC manner.

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Composition controlled synthesis of PCL–PEG Janus nanoparticles: magnetite nanoparticles prepared from one-pot photo-click reaction

Cited by 29 publications

References 38 publications

A biotechnological perspective on the application of iron oxide nanoparticles

A biotechnological perspective on the application of iron oxide nanoparticles

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

Compact Magneto‐Fluorescent Colloids by Hierarchical Assembly of Dual‐Components in Radial Channels for Sensitive Point‐of‐Care Immunoassay

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