The requirements related to reducing the carbon footprint of cement production have directed the attention of researchers to the use of waste materials such as blast-furnace slag or fly ashes, either as a partial replacement for cement clinker or in the form of new alternative binders. This paper presents alkali-activated materials (AAMs) based on blast-furnace slag partially replaced with fly ash, metakaolin, or zeolite, activated with water glass or water glass with a small amount of water, and doped with zinc oxide. The mortars were tested for flow, hydration heat, mechanical strength, microstructure, and antimicrobial activity. The obtained test results indicate the benefits of adding water, affecting the fluidity and generating a less porous microstructure; however, the tested hydration heat, strength, and antibacterial properties are related to more favorable properties in AAMs produced on water glass alone.