Composition of Essential Oil Compounds from Different Syrian Populations of Origanum syriacum L. (Lamiaceae)

Lukas, Brigitte; Schmiderer, Corinna; Franz, Chlodwig; Novak, Johannes

doi:10.1021/jf802963h

Cited by 79 publications

(53 citation statements)

References 30 publications

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“…EO has been found widely applications in many areas such as medicine and pharmaceutical, cosmetic, agricultural and food industries (Bakkali et al, 2008;Lukas et al, 2009 (Dutra et al, 2009b). A predominance of sesquiterpene was found analyzing the chemical composition of EO from P. emarginatus seeds, being trans-caryophyllene the one in highest concentration.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Dutra¹,

Pittella²,

Dittz³

et al. 2012

Rev. bras. farmacogn.

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Pterodon emarginatus Vogel, Fabaceae, is a native aromatic tree distributed by central region of Brazil. Hydroalcoholic infusions of the seeds are used in folk medicine for their anti-rheumatic and anti-inflammatory properties. The objective of this work was identified the chemical components and verify the cytotoxic effect of the essential oil (EO) from P. emarginatus seeds. Thus, the EO of P. emarginatus seeds was analyzed by GC/MS analysis followed by brine shrimp lethality test and cytotoxic activity against tumor cell lines and human peripheral mononuclear blood cells (PBMC). The cancer cell lines tested were C 6 (rat glioma), MeWo (human melanoma), CT 26 .WT (mouse colon carcinoma), MDA (human breast cancer), A 549 (human lung carcinoma), B 16 -F 1 (mouse melanoma), CHO-K1 (hamster ovary cell) and BHK-21 (hamster kidney fibroblast). Eleven compounds were identified by GC and CG/MS analyses. The main compounds with concentrations higher than 5% were β-elemene (15.3%), trans-caryophyllene (35.9%), α-humulene (6.8%), germacrene-D (9.8%), bicyclo germacrene (5.5%) and spathulenol (5.9%). The EO of P. emarginatus seeds showed toxicity to Artemia salina (LC50 1.63 μg/mL) and was active against all the cell lines tested. The potent cytotoxic activity had IC50 values ranging from 24.9 to 47 μg/mL. However, EO (1-100 µg/mL) had less cytotoxicity in PBMCs isolated from a healthy subject. In summary, the present study showed the potential antiproliferative of the EO of P. emarginatus seeds.

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Section: Resultsmentioning

confidence: 99%

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Dutra¹,

Pittella²,

Dittz³

et al. 2012

Rev. bras. farmacogn.

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“…in YES broth, at a concentration of 0.1 mL/mL [18]. Additionally, the carvacrol and thymol were identified as the main components of the oregano E.O, responsible for its antifungal activities [19,20,21]. Similarly, the E.O of the thyme also showed an antifungal effect on the growth of F. verticillioides , A. parasiticus , A. flavus and A. parasiticus due to the presence of the thymol, thyme’s main component [22,23,24].…”

Section: Discussionmentioning

confidence: 99%

Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Khoury

Atoui

Verheecke‐Vaessen

et al. 2016

Toxins

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Ochratoxin A (OTA) is a mycotoxin, mainly produced on grapes by Aspergillus carbonarius, that causes massive health problems for humans. This study aims to reduce the occurrence of OTA by using the ten following essential oils (E.Os): fennel, cardamom, anise, chamomile, celery, cinnamon, thyme, taramira, oregano and rosemary at 1 µL/mL and 5 µL/mL for each E.O.As a matter of fact, their effects on the OTA production and the growth of A. carbonarius S402 cultures were evaluated, after four days at 28 °C on a Synthetic Grape Medium (SGM). Results showed that A. carbonarius growth was reduced up to 100%, when cultured with the E.Os of cinnamon, taramira, and oregano at both concentrations and the thyme at 5 µL/mL. As for the other six E.Os, their effect on A. carbonarius growth was insignificant, but highly important on the OTA production. Interestingly, the fennel E.O at 5 µL/mL reduced the OTA production up to 88.9% compared to the control, with only 13.8% of fungal growth reduction. We further investigated the effect of these E.Os on the expression levels of the genes responsible for the OTA biosynthesis (acOTApks and acOTAnrps along with the acpks gene) as well as the two regulatory genes laeA and vea, using the quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) method. The results revealed that these six E.Os reduced the expression of the five studied genes, where the ackps was downregulated by 99.2% (the highest downregulation in this study) with 5 µL/mL of fennel E.O.As for the acOTApks, acOTAnrps, veA and laeA, their reduction levels ranged between 10% and 96% depending on the nature of the E.O and its concentration in the medium.

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“…While the fatty acids in the OS essential oil generally contains polymorphic compounds, such as thymol and carvacrol, compounds, such as γ-terpinene, P-cymene, and thymoquinene, can also be found depending on the growing area (Lukas et al, 2009) . Some studies have reported that essential fatty acids in OS have antioxidant (Luna et al, 2010;Tavarez et al, 2011), anti-microbial (Mitsch et al, 2004;Gürakan et al, 2008), anti-inflammatory (Yoshino et al, 2006), anti-viral (Pilau et al, 2011), anti-tumoral (El-desoukya et al, 2009Al-kalaldeh et al, 2010), anti-ulcer (Afify et al, 2012), anti-fungal (Manohar et al, 2001), and anti-parasitic (Değerli et al, 2012;Remmal et al, 2013) properties, all of which have positive effects on stock performance (Jang et al, 2007;Tekçe & Gül, 2016).…”

Section: Effects Of Origanum Syriacum Essential Oil On Blood Parametementioning

confidence: 99%

Effects of Origanum Syriacum Essential Oil on Blood Parameters of Broilers Reared at High Ambient Heat

Tekce

Gül

2017

Rev. Bras. Cienc. Avic.

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Composition of Essential Oil Compounds from Different Syrian Populations of Origanum syriacum L. (Lamiaceae)

Cited by 79 publications

References 30 publications

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius

Effects of Origanum Syriacum Essential Oil on Blood Parameters of Broilers Reared at High Ambient Heat

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